TRANSCRIPTOMIC

作品数：239被引量：592H指数：11
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Single-cell transcriptomic sequencing identifies subcutaneous patient-derived xenograft recapitulated medulloblastoma
《Animal Models and Experimental Medicine》2025年第3期458-472,共15页Jiayu Gao Yahui Zhao Ziwei Wang Fei Liu Xuan Chen Jialin Mo Yifei Jiang Yongqiang Liu Peiyi Tian Yanong Li Kaiwen Deng Xueling Qi Dongming Han Zijia Liu Zhengtao Yang Yixi Chen Yujie Tang Chunde Li Hailong Liu Jiankang Li Tao Jiang 
National Key Research and Development Program of China,Grant/Award Number:2022ZD0210100;Beijing Nova Star Program,Grant/Award Number:2022002;Natural Science Foundation of Beijing and Haidian Collaboration Foundation,Grant/Award Number:L232079;National Natural Science Foundation of China,Grant/Award Number:82172608,82273343,81902975 and 82101356;Capital Medical University Fund for Excellent Young Scholars,Grant/Award Number:KCB2304。
Background:Medulloblastoma(MB)is one of the most common malignant brain tumors that mainly affect children.Various approaches have been used to model MB to facilitate investigating tumorigenesis.This study aims to com...
关键词：experimental models MEDULLOBLASTOMA single-cell sequencing sPDX 
Transcriptomic,histological and biochemical analyses of Macrobrachium nipponense response to acute heat stress
《Aquaculture and Fisheries》2025年第1期27-38,共12页Xiao Wu Yaoran Fan Jianbin Feng Keyi Ma Jiale Li 
supported by the Innovation Action Plan Project of the Science and Technology Commission of Shanghai Municipality,China(19391900900,21002410500).
Temperature is an essential environmental factor affecting the viability of organisms.Temperature changes could cause damages or even death.The oriental river prawn,Macrobrachium nipponense,is widely distributed in Ea...
关键词：Macrobrachium nipponense Acute heat stress HISTOLOGY BIOCHEMISTRY Key regulatory genes and pathway 
Integrative transcriptomic and proteomic analysis reveals that SERPING1 inhibits neuronal proliferation via the CaMKII-CREB-BDNF pathway in schizophrenia
《World Journal of Psychiatry》2025年第2期193-208,共16页Feng Li Xing Ren Jia-Xiu Liu Tian-Dao Wang Bi Wang Xiao-Bin Wei 
Supported by the Key R&D Projects of Hainan Province,No.ZDYF2022SHFZ295.
BACKGROUND Schizophrenia(SZ),a chronic and widespread brain disorder,presents with complex etiology and pathogenesis that remain inadequately understood.Despite the absence of a universally recognized endophenotype,pe...
关键词：TRANSCRIPTOMICS Proteomics SCHIZOPHRENIA SERPING1 Pathogenesis 
Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses
《Traditional Medicine Research》2025年第2期55-64,共10页Jin-Fang Wu Yi-Sheng Chen Yu-Chun Xie 
Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditio...
关键词：single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity 
Transcriptomic Analysis and Computational Study Provide Insights into the Mechanism of Anti-tumor Activity of CuB and CuE on HepG2 cells
《Medicinal Plant》2025年第1期39-48,共10页Ru CHEN Wuyi BAN Shitong SONG Haoran MA Yuxin ZHENG Lei SONG 
[Objectives]To study the effect of carcinoma cell line(HepG2)and mechanism of anti-tumor activity of cucurbitacin B(CuB)and cucurbitacin E(CuE)on HepG2 cells.[Methods]HepG2 cells were treated with various concentratio...
关键词：TRANSCRIPTOMIC Cucurbitacin B Cucurbitacin E HepG2 cells 
Transcriptomic and behavioral studies reveal that glutamate receptors are involved in depressive-like behavior in adult olive flounder Paralichthys olivaceus
《Aquaculture and Fisheries》2025年第1期115-123,共9页Liangfang Liu Tangsong Feng Mengmeng Shi Huafeng Zou Weiqun Lu 
supported by grants from the National Natural Science Foundation of China(32273103).
Olive flounder(Paralichthys olivaceus),a marine demersal flatfish species,exhibits obvious timid and depressive-like characteristics.Adult olive flounder bury themselves in the sand and present motionless behavior.How...
关键词：Olive flounder Spinal cord RIBOSOME depressive-like behavior Glutamate receptor 
Dentate Gyrus Morphogenesis is Regulated by an Autism Risk Gene Trio Function in Granule Cells
《Neuroscience Bulletin》2025年第1期1-15,共15页Mengwen Sun Weizhen Xue Hu Meng Xiaoxuan Sun Tianlan Lu Weihua Yue Lifang Wang Dai Zhang Jun Li 
supported by grants from the Key Realm R&D Program of Guangdong Province(2019B030335001);the National Natural Science Foundation of China(82071541,81971283,82271576,and 82101570);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2023-PT320-08).
Autism Spectrum Disorders(ASDs)are reported as a group of neurodevelopmental disorders.The structural changes of brain regions including the hippocampus were widely reported in autistic patients and mouse models with ...
关键词：TRIO Autism spectrum disorders Dentate gyrus morphogenesis Neuron migration Spatial transcriptomic sequencing 
Unveiling the anti-inflammatory effects and mechanisms of LM49 in a carrageenan-induced acute inflammation model
《Journal of Chinese Pharmaceutical Sciences》2025年第1期41-54,共14页Fan Yang Rui Li Wenting Liu Jian Sun Chengxiao Zhao Xiue Feng Qingshan Li 
The National Natural Science Foundation of China(Grant No.82003770);the National Science and Technology Major Project of China(Grant No.2018ZX09711001-001-017);the Key Research and Development Plan of Shanxi Province(Grant No.202102130501005)。
This study aimed to investigate the anti-inflammatory properties and underlying molecular mechanisms of 2,4',5'-trihydroxyl-5,2'-dibromo diphenylmethanone(LM49)using a carrageenan-induced paw edema model in mice,which...
关键词：ANTI-INFLAMMATION TRANSCRIPTOMIC Molecular docking CARRAGEENAN 2 4' 5'-Trihydroxyl-5 2'-dibromo diphenylmethanone 
Genes and proteins expressed at different life cycle stages in the model protist Euplotes vannus revealed by both transcriptomic and proteomic approaches
《Science China(Life Sciences)》2025年第1期232-248,共17页Yaohan Jiang Xiao Chen Chundi Wang Liping Lyu Saleh A.Al-Farraj Naomi A.Stover Feng Gao 
supported by the Science&Technology Innovation Project of Laoshan Laboratory(LSKJ202203202);the National Natural Science Foundation of China(31922013,32270539);Natural Science Foundation of Shandong Province(ZR2020JQ13);Fundamental Research Funds for the Central Universities(202141004);the Researchers Supporting Project(RSP2024R7)King Saud University,Riyadh,Saudi Arabia.
Sexual reproduction first appeared in unicellular protists and has continued to be an essential biological process in almost all eukaryotes.Ciliated protists, which contain both germline and somatic genomes within a s...
关键词：sexual reproduction TRANSCRIPTOMIC PROTEOMIC genome rearrangement PIWI NHEJ 
Effects of aflatoxin B1 on subacute exposure of hybrid groupers(Epinephelus fuscoguttatus♀×Epinephelus lanceolatus♂):Growth,liver histology,and integrated liver transcriptome and metabolome analysis
《Animal Nutrition》2024年第4期192-214,共23页Hao Liu Shuqing Liang Weibin Huang Yuanzhi Yang Menglong Zhou Baiquan Lu Biao Li Wenshan Cai Hengyang Song Beiping Tan Xiaohui Dong 
supported financially by the Research and Demonstration of Precision Functional Compound Feed Technology of Major Cultured Fishes and Shrimps in South China,China(2021B0202050002);the Department of Education of Guangdong Province,China(2021ZDZX4005);the China Agriculture Research System of MOF and MARA,China(CARS-47).
With the increasing incorporation of plant-based ingredients into the grouper diet,the issue of aflatoxin B1(AFB1)contamination in the diet has become a significant concern.In this study,the negative effects of AFB1 o...
关键词：Aflatoxin B1 Hybrid grouper TRANSCRIPTOMIC Metabolomic LIVER 
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