TRANSCRIPTOMIC

作品数：245被引量：594H指数：11
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相关机构：中山大学浙江大学南京农业大学华中农业大学更多>>
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Insights into the transcriptomic heterogeneity of brain endothelial cells in normal aging and Alzheimer’s disease
《Neural Regeneration Research》2026年第2期569-576,共8页Qian Yue Shang Li Chon Lok Lei Huaibin Wan Zaijun Zhang Maggie Pui Man Hoi 
supported by the National Natural Science Foundation of China,Nos.82404892(to QY),82061160374(to ZZ);the Science and Technology Development Fund,Macao Special Administrative Region,China,Nos.0023/2020/AFJ,0035/2020/AGJ;the University of Macao Research Grant,Nos.MYRG2022-00248-ICMS,MYRG-CRG2022-00010-ICMS(to MPMH);the Natural Science Foundation of Guangdong Province,No.2024A1515012818(to ZZ);the Fundamental Research Funds for the Central Universities,No.21623114(to ZZ).
Drug development for Alzheimer’s disease is extremely challenging,as demonstrated by the repeated failures of amyloid-β-targeted therapeutics and the controversies surrounding the amyloid-βcascade hypothesis.More r...
关键词：Alzheimer’s disease brain microvessel endothelial cells transcriptomic heterogeneity endothelial activation blood-brain barrier impairment neurovascular cell-cell communication 
Prediction of genomic biomarkers for endometriosis using the transcriptomic dataset
《World Journal of Clinical Cases》2025年第20期6-19,共14页Zeynep Kucukakcali Sami Akbulut Cemil Colak 
approved by the Inonu University institutional review board for noninterventional studies(Approval No:2022/3842).
BACKGROUND Endometriosis is a clinical condition characterized by the presence of endometrial glands outside the uterine cavity.While its incidence remains mostly uncertain,endometriosis impacts around 180 million wom...
关键词：ENDOMETRIOSIS RNA-SEQ TRANSCRIPTOMICS Machine learning Classification 
Inflammatory transcriptomic signatures and cell type compositions in inflamed and non-inflamed colonic mucosa of ulcerative colitis Ulcerative colitis
《Genes & Diseases》2025年第3期72-75,共4页Eun Mi Song Jahanzeb Saqib Yang Hee Joo Zehra Ramsha Chang Mo Moon Sung-Ae Jung Junil Kim 
supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education of the Republic of Korea(No.2020R1I1A1A01073545 to E.M.S.,2020R1A2C1010786 to C.M.M.,2021R1A6A1A10044154 to J.K).
Inflammatory transcriptomic signatures and cell type compositions in inflamed and non-inflamed colonic mucosa of ulcerative colitis Ulcerative colitis(UC),a subtype of inflammatory bowel disease,arises from disrupted ...
关键词：cell type compositions aberrant innate immune response intestinal microbiota colonic mucosa disrupted gut homeostasisprimarily healing mucosal inflammation ulcerative colitis uc ulcerative colitis 
Assessment of the transcriptomic consequences and MAU2 protein levels in edited induced pluripotent stem cells with NIPBL pathogenic variants
《Genes & Diseases》2025年第3期68-71,共4页Kévin Cassinari Anne Rovelet-Lecrux Céline Derambure Myriam Vezain Sophie Coutant Anne-Claire Richard Nathalie Drouot Juliette Coursimault Gabriella Vera Alice Goldenberg Pascale Saugier-Veber Camille Charbonnier Gaël Nicolas 
the Institutional Review Board of the Rouen University Hospital(CERDE notification E2023-65).
Cornelia de Lange Syndrome(CdLS)is an intellectual disability syndrome characterized by distinctive clinical features including growth retardation,limb malformation,and a characteristic facial dysmorphism.1 Six genes,...
关键词：gene expression regulation growth retardationlimb mau protein levels nipbl pathogenic variants facial dysmorphism transcriptomic consequences organizing chromatin intellectual disability syndrome 
Shenzhuo formulation ameliorates diabetic nephropathy by regulating cytochrome P450-mediated arachidonic acid metabolism
《World Journal of Diabetes》2025年第5期331-345,共15页Zhong-Yong Zhang Yu-Ming Wang Ning Wang Yuan-Song Wang Hui Zhang Duo Wang Li-Xin Wang Huan-Tian Cui Wei-Bo Wen Shu-Quan Lv Yong-Jun Cao 
Supported by the Natural Science Foundation of Hebei Province Beijing-Tianjin-Hebei Basic Research Special Program,No.H2020110287;Key Laboratory for Diabetic Kidney Disease Syndrome and Treatment of the Traditional Chinese Medicine Administration of Hebei Province,No.7[2024];Yuansong Wang National Famous Traditional Chinese Medicine Expert Heritage Studio,No.3[2024];Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine for Diabetes and Its Complications,No.SZX2020015;Jiangsu Province Chinese Medicine Science and Technology Development Program Project,No.YB2020065.
BACKGROUND Diabetic nephropathy(DN)is a major complication of diabetes,marked by progressive renal damage and an inflammatory response.Although research has investigated the pathological mechanisms underlying DN,effec...
关键词：Diabetic nephropathy Shenzhuo formulation TRANSCRIPTOMIC METABOLOMIC Cytochrome P450 Arachidonic acid metabolic INFLAMMATORY Oxidative stress 
Genomic,transcriptomic,and metabolomic analyses reveal convergent evolution of oxime biosynthesis in Darwin’s orchid
《Molecular Plant》2025年第3期392-415,共24页Kai Jiang Birger Lindberg Møller Shaofan Luo Yu Yang David R.Nelson Elizabeth Heather Jakobsen Neilson Joachim Møller Christensen Kai Hua Chao Hu Xinhua Zeng Mohammed Saddik Motawie Tao Wan Guang-Wan Hu Guy Eric Onjalalaina Yijiao Wang Juan Diego Gaitán-Espitia Zhiwen Wang Xiao-Yan Xu Jiamin He Linying Wang Yuanyuan Li Dong-Hui Peng Siren Lan Huiming Zhang Qing-Feng Wang Zhong-Jian Liu Wei-Chang Huang 
supported by grants from the Shanghai Landscaping and City Appearance Administrative Bureau(G222406,G232408);Sino-Africa Joint Research Center,CAS(SAJC201607);the Science and Technology Commission of Shanghai Municipality(19390743600);the National Wild Plant Germplasm Resource Centre for Shanghai Chenshan Botanical Garden(ZWGX2102);to W.C.H.and K.J.,and by a Distinguished Investigator grant(NNF190CO05456);from the Novo Nordisk Foundation to B.L.M.E.H.J.N.acknowledges funding from the Novo Nordisk Foundation(0054890);the Independent Research Fund Denmark(1131-00002B and 1051-00083 B).
Angraecum sesquipedale,also known as Darwin’s orchid,possesses an exceptionally long nectar spur.Charles Darwin predicted the orchid to be pollinated by a hawkmoth with a correspondingly long proboscis,later identifi...
关键词：Angraecum sesquipedale whole genome sequence white floral scent convergent evolution flavin monooxygenase CYP79 absence 
Single-cell transcriptomic sequencing identifies subcutaneous patient-derived xenograft recapitulated medulloblastoma
《Animal Models and Experimental Medicine》2025年第3期458-472,共15页Jiayu Gao Yahui Zhao Ziwei Wang Fei Liu Xuan Chen Jialin Mo Yifei Jiang Yongqiang Liu Peiyi Tian Yanong Li Kaiwen Deng Xueling Qi Dongming Han Zijia Liu Zhengtao Yang Yixi Chen Yujie Tang Chunde Li Hailong Liu Jiankang Li Tao Jiang 
National Key Research and Development Program of China,Grant/Award Number:2022ZD0210100;Beijing Nova Star Program,Grant/Award Number:2022002;Natural Science Foundation of Beijing and Haidian Collaboration Foundation,Grant/Award Number:L232079;National Natural Science Foundation of China,Grant/Award Number:82172608,82273343,81902975 and 82101356;Capital Medical University Fund for Excellent Young Scholars,Grant/Award Number:KCB2304。
Background:Medulloblastoma(MB)is one of the most common malignant brain tumors that mainly affect children.Various approaches have been used to model MB to facilitate investigating tumorigenesis.This study aims to com...
关键词：experimental models MEDULLOBLASTOMA single-cell sequencing sPDX 
Avian tuberculosis identified as the potential diseasein an outbreak in wild migratory birds in China
《mLife》2025年第1期101-103,共3页Chunge Zhang Liang Wang Cheng Zhang Ning Zhang Heting Sun Dong Chu Siyuan Qin Zhenghai Ma Marina Gulyaeva Alexander Shestopalov Wenjun Liu George F.Gao Yuhai Bi 
approved by the Animal Ethics Committee ofthe Institute of Microbiology,Chinese Academy of Sciences(Approval Number:APIMCAS2018034 and APIMCAS2021112).
Impact statementThis study identifies avian tuberculosis as a potential cause of mass mortality in wild migratory birds in Inner Mongolia,China.Combining meta-transcriptomic sequencing and histopathological analysis,it...
关键词：disease associated pathogens Inner Mongolia avian tuberculosis surveillance wildlifediseases migratory birds meta transcriptomic sequencing histopathological analysisit wild migratory birds 
Transcriptomic,histological and biochemical analyses of Macrobrachium nipponense response to acute heat stress
《Aquaculture and Fisheries》2025年第1期27-38,共12页Xiao Wu Yaoran Fan Jianbin Feng Keyi Ma Jiale Li 
supported by the Innovation Action Plan Project of the Science and Technology Commission of Shanghai Municipality,China(19391900900,21002410500).
Temperature is an essential environmental factor affecting the viability of organisms.Temperature changes could cause damages or even death.The oriental river prawn,Macrobrachium nipponense,is widely distributed in Ea...
关键词：Macrobrachium nipponense Acute heat stress HISTOLOGY BIOCHEMISTRY Key regulatory genes and pathway 
Integrative transcriptomic and proteomic analysis reveals that SERPING1 inhibits neuronal proliferation via the CaMKII-CREB-BDNF pathway in schizophrenia
《World Journal of Psychiatry》2025年第2期193-208,共16页Feng Li Xing Ren Jia-Xiu Liu Tian-Dao Wang Bi Wang Xiao-Bin Wei 
Supported by the Key R&D Projects of Hainan Province,No.ZDYF2022SHFZ295.
BACKGROUND Schizophrenia(SZ),a chronic and widespread brain disorder,presents with complex etiology and pathogenesis that remain inadequately understood.Despite the absence of a universally recognized endophenotype,pe...
关键词：TRANSCRIPTOMICS Proteomics SCHIZOPHRENIA SERPING1 Pathogenesis 
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