RNA-SEQ

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盐酸青藤碱抑制急性T淋巴细胞白血病CEM细胞株的作用及转录组学分析
《中国组织工程研究》2025年第31期6674-6680,共7页康林之 刘振帅 魏佳旭 常娜 朱大诚 
江西省“双一流”学科(中医学)建设资助项目(JXYLXK-ZHYI051),项目参与人:朱大诚;2022江西中医药大学校级研究生创新专项资金项目(JZYC22B01),项目负责人:康林之。
背景:盐酸青藤碱有抗多种肿瘤的作用,但目前尚不清楚盐酸青藤碱对急性T淋巴细胞白血病的作用。目的:探讨盐酸青藤碱对急性T淋巴细胞白血病CEM细胞的抑制作用。方法:应用不同浓度(0.5,1,2,4 mmol/L)盐酸青藤碱处理CEM细胞,CCK-8检测细胞...
关键词：盐酸青藤碱 急性T淋巴细胞白血病 CEM细胞 细胞凋亡 RNA-seq测序 增殖抑制 工程化细胞 
Prediction of genomic biomarkers for endometriosis using the transcriptomic dataset
《World Journal of Clinical Cases》2025年第20期6-19,共14页Zeynep Kucukakcali Sami Akbulut Cemil Colak 
approved by the Inonu University institutional review board for noninterventional studies(Approval No:2022/3842).
BACKGROUND Endometriosis is a clinical condition characterized by the presence of endometrial glands outside the uterine cavity.While its incidence remains mostly uncertain,endometriosis impacts around 180 million wom...
关键词：ENDOMETRIOSIS RNA-SEQ TRANSCRIPTOMICS Machine learning Classification 
Endoplasmic reticulum stress and forkhead box protein O1 inhibition mediate palmitic acid and high glucose-inducedβ-cell dedifferentiation
《World Journal of Diabetes》2025年第5期216-233,共18页Li-Kun Wang Chu-Chu Kong Ting-Yan Yu Hui-Song Sun Lu Yang Ying Sun Ming-Yu Li Wei Wang 
Supported by the Natural Science Foundation of China,No.81471081;the Natural Science Foundation of Fujian Province,No.2023D009;the Natural Science Foundation of Xiamen City,No.3502Z202373104 and No.3502Z20227162;Scientific Research Foundation for Advanced Talents,Xiang’an Hospital of Xiamen University,No.PM201809170005。
BACKGROUND Type 2 diabetes mellitus is characterized by pancreaticβ-cell dysfunction and insulin resistance.Studies have suggested thatβ-cell dedifferentiation is one of the pathogeneses ofβ-cell dysfunction,but th...
关键词：β-cell dedifferentiation High glucose and palmitic acid Forkhead box O1 RNA-sequencing Endoplasmic reticulum stress 
FOXO1在甲状腺乳头状癌组织中的表达及其临床意义
《生物医学工程与临床》2025年第2期240-249,共10页韦干观 李柳艳 危丹明 庞玉艳 陈罡 史琳 
广西壮族自治区卫生健康委员会科研课题(Z20191026,Z20201138);广西医科大学第二附属医院优秀后备人才项目(HBRC201804)。
目的检测叉头框蛋白O1(FOXO1)在甲状腺乳头状癌(PTC)患者中的表达,探讨其潜在的分子机制。方法收集90例PTC及23例非癌甲状腺组织(组织芯片编号THC1021和THC961,桂林泛谱公司),以及40例PTC和64例非癌甲状腺组织样本(广西医科大学第一附...
关键词：FOXO1 甲状腺乳头状癌 免疫组化 RNA-SEQ 基因芯片 scRNA-seq 
Osa-miR166i-3p介导活性氧积累途径正调控水稻纹枯病抗性
《中国水稻科学》2025年第2期187-196,共10页冯涛 张朝阳 黄新妮 王月 钟旭志 冯志明 刘欣 左示敏 欧阳寿强 
江苏省重点研发计划现代农业项目(BE2022335);扬州大学大学生创新创业项目(XCX20230650)。
【目的】纹枯病是水稻上的重要病害,严重影响稻米品质和产量。在感病的粳型常规水稻品种徐稻3号和高抗籼粳交后代群体YSBR1中,Osa-miR166i-3p响应立枯丝核菌(Rhizoctonia solani)的侵染。明确Osa-miR166i-3p在水稻抗纹枯病过程中发挥的...
关键词：水稻 纹枯病 Osa-miR166i-3p 生物学功能 RNA-SEQ 
p65通过调控脂代谢影响HepG2细胞增殖研究
《实用肝脏病杂志》2025年第2期173-177,共5页李全维 高明慧 寇卜心 柴梦音 霍云飞 豆双双 庞丽君 石英 刘晓霓 
国家自然科学基金资助项目(编号:82003200);北京市属医学科研院所公益发展改革试点项目(编号:京医研2021-10);北京市自然科学基金资助项目(编号:7192084);首都卫生发展科研专项基金资助项目(编号:2020-2-1152)。
目的p65作为NF-κB家族重要的转录因子,在肝细胞癌进展过程中发挥着重要作用。本研究旨在探索p65对HepG2细胞脂代谢调控的影响。方法应用数据库分析p65表达与HCC患者预后的关系。采用ChIP-seq和RNA-seq技术,采用生物信息学分析探究HepG...
关键词：肝细胞癌 P65 CHIP-SEQ RNA-SEQ 细胞增殖 脂代谢 体外 
基于RNA-seq和PER-seq联合分析探究ZmHDZ6表达调控网络
《作物学报》2025年第4期958-968,共11页方应浩 周波 陈茹梅 杨文竹 秦慧民 
国家自然科学基金项目(32372064)资助。
玉米是需水量较大的作物,而干旱是制约玉米生产的主要因素。结合前期研究基础和相关研究进展,发现ZmHDZ6受干旱诱导强烈,且过表达植株表现出优良的抗旱性能。为探究玉米转录因子ZmHDZ6的下游调控机制,通过对ZmHDZ6过表达转基因玉米株系...
关键词：RNA-SEQ PER-seq 转录因子 ZmHDZ6 靶基因 MOTIF 
RNA-seq analysis of mitochondria-related genes regulated by AMPK in the human trophoblast cell line BeWo
《Animal Models and Experimental Medicine》2025年第4期649-661,共13页Bin Wu Albert Gao Bin He Yun Chen Xiangfeng Kong Fayuan Wen Haijun Gao 
Dean's Office Howard University College of Medicine,Grant/Award Number:Bridge Fund/Pilot Study Award;National Center on Minority Health and Health Disparities,Grant/Award Number:RCMI/IDC Award U54MD007597;National Institute of Child Health and Human Development,Grant/Award Number:R03HD095417 and R16HD116702。
Background:How AMP activated protein kinase(AMPK)signaling regulates mito-chondrial functions and mitophagy in human trophoblast cells remains unclear.This study was designed to investigate potential players mediating...
关键词：AMPK ATP production gene expression MITOCHONDRIA RNA-SEQ TROPHOBLAST 
The implications of single-cell RNA-seq analysis in prostate cancer:unraveling tumor heterogeneity,therapeutic implications and pathways towards personalized therapy
《Military Medical Research》2025年第2期220-241,共22页De-Chao Feng Wei-Zhen Zhu Jie Wang Deng-Xiong Li Xu Shi Qiao Xiong Jia You Ping Han Shi Qiu Qiang Wei Lu Yang 
Chinese Scholarship Council(202206240086);National Natural Science Foundation of China(81974099,82170785,81974098,82170784);National Key Research and Development Program of China(2021YFC2009303);programs from Science and Technology Department of Sichuan Province(2021YFH0172);Young Investigator Award of Sichuan University 2017(2017SCU04A17);Technology Innovation Research and Development Project of Chengdu Science and Technology Bureau(2019-YF05-00296-SN);Sichuan University-Panzhihua science and technology cooperation special fund(2020CDPZH-4).
In recent years,advancements in single-cell and spatial transcriptomics,which are highly regarded developments in the current era,particularly the emerging integration of single-cell and spatiotemporal transcriptomics...
关键词：Prostate cancer Single-cell RNA sequencing(scRNA-seq) Tumor microenvironment Tumor heterogeneity Treatment resistance Precision medicine 
Advancing skeletal health and disease research with single-cell RNA sequencing
《Military Medical Research》2025年第2期285-310,共26页Peng Lin Yi-Bo Gan Jian He Si-En Lin Jian-Kun Xu Liang Chang Li-Ming Zhao Jun Zhu Liang Zhang Sha Huang Ou Hu Ying-Bo Wang Huai-Jian Jin Yang-Yang Li Pu-Lin Yan Lin Chen Jian-Xin Jiang Peng Liu 
National Key Research and Development Program of China(2022YFA1103202);National Natural Science Foundation of China(82272507,32270887,and 32200654);Natural Science Foundation of Chongqing(CSTB2023NSCQ-ZDJO008);Postdoctoral Innovative Talent Support Program(BX20220397);Independent Research Project of State Key Laboratory of Trauma and Chemical Poisoning(SFLKF202201);Project for Enhancing Innovation of Army Medical University(2023X1839);Talent Innovation Training Program at the Army Medical Center(ZXZYTSYS09);General Hospital of Western Theater Command Research Project(2021-XZYG-B10);University Grants Committee,Research Grants Council of Hong Kong,China(14113723,N_CUHK472/22,C7030-18G,T13-402/17-N,and AoE/M-402/20)。
Orthopedic conditions have emerged as global health concerns,impacting approximately 1.7 billion individuals worldwide.However,the limited understanding of the underlying pathological processes at the cellular and mol...
关键词：Skeletal disorders Musculoskeletal system Single-cell RNA sequencing(scRNA-seq) Cellular heterogeneity Single cell suspension Bioinformatic analysis 
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