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MOTIF: 作品数：364被引量：693H指数：12; 导出分析报告; 相关领域：生物学医药卫生更多>>; 相关作者：赵丹枫李成贵张维强陈国强孙之荣更多>>; 相关机构：中国科学院北京理工大学中国科学院大学北京大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>

C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury: 《Neural Regeneration Research》2025年第8期2231-2244,共14页Xiangzi Wang Xiaofei Niu Yingkai Wang Yang Liu Cheng Yang Xuyi Chen Zhongquan Qi; supported by the National Natural Science Foundation of China(Key Program),No.11932013;the National Natural Science Foundation of China(General Program),No.82272255;Armed Police Force High-Level Science and Technology Personnel Project;The Armed Police Force Focuses on Supporting Scientific and Technological Innovation Teams;Key Project of Tianjin Science and Technology Plan,No.20JCZDJC00570(all to XC)。; Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.The expression of the C-C motif chemokine ligand...; 关键词：apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

基于RNA-seq和PER-seq联合分析探究ZmHDZ6表达调控网络: 《作物学报》2025年第4期958-968,共11页方应浩周波陈茹梅杨文竹秦慧民; 国家自然科学基金项目(32372064)资助。; 玉米是需水量较大的作物,而干旱是制约玉米生产的主要因素。结合前期研究基础和相关研究进展,发现ZmHDZ6受干旱诱导强烈,且过表达植株表现出优良的抗旱性能。为探究玉米转录因子ZmHDZ6的下游调控机制,通过对ZmHDZ6过表达转基因玉米株系...; 关键词：RNA-SEQ PER-seq 转录因子 ZmHDZ6 靶基因 MOTIF

Harnessing the Streptomyces-originating typeⅠ-E CRISPR/Cas system for efficient genome editing in Streptomyces: 《Science China(Life Sciences)》2025年第4期1174-1182,共9页Yuhui Xie Xiaoyan Liu Tingting Wu Yunzi Luo; supported by the National Key Research and Development Program of China(2018YFA0903300);the National Natural Science Foundation of China(32071426);the KeyArea Research and Development Program of Guangdong Province(2020B0303070002);the Haihe Laboratory of Sustainable Chemical Transformations(24HHWCSS00006)。; Since their discovery,CRISPR/Cas systems have significantly expanded the genetic toolbox,aiding in the exploration and enhanced production of natural products across various microbes.Among these,class 2 CRISPR/Cas sys...; 关键词：genome editing type I-E CRISPR/Cas system STREPTOMYCES protospacer adjacent motif(PAM) identification natural product

Blocking the PD-1 signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2: 《Science China(Life Sciences)》2025年第1期189-203,共15页Wenjie Li Wenyi Mei Hewei Jiang Jie Wang Xiaoli Li Lina Quan Yanyan Diao Yanni Ma Sisi Fan Zhuwei Xie Mengdie Gong Huan Zhu Dewen Bi Feng Zhang Lei Ma Jian Zhang Yufeng Gao Aris Paschalidis Honghuang Lin Fangfang Liu Kangdong Liu Mingliang Ye Zhenjiang Zhao Yajun Duan Zhuo Chen Yufang Xu Weilie Xiao Shengce Tao Lili Zhu Honglin Li; supported in part by the National Natural Science Foundation of China (81825020, 82150208, 82260682);the National Key R&D Program of China (2022YFC3400501, 2022YFC3400504);the Shanghai Science and Technology Commission Biomedical Science and Technology Support Special Project (21S11907900, 20S11901000);Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform (2022YKZY001);sponsored by the National Program for Special Supports of Eminent Professionals;National Program for Support of Top-notch Young Professionals; Targeting the PD-1/PD-L1 axis with small-molecular inhibitors is a promising approach for immunotherapy.Here,we identify a natural pentacyclic triterpenoid,Pygenic Acid A(PA),as a PD-1 signaling inhibitor.PA exerts an...; 关键词：pygenic acid A programmed death-1 immunoreceptor tyrosine-based switch motif SH2 domain-containing protein-tyrosine phosphatase-2 target identification site recognition

CXCL16 promotes proliferation of head and neck squamous cell carcinoma by regulating GPX1-mediated antioxidant levels: 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第1期92-106,共15页Ru HE Hongyi JIANG Chengchi ZHANG Yuan CHEN Wenshun LIU Xinyue DENG Xiaozheng ZHU Yunye LIU Chuanming ZHENG Yining ZHANG Chengying SHAO Yanting DUAN Jiajie XU; supported by the Scientific Research Fund of the National Health Commission-Zhejiang Provincial Health Major Science and Technology Plan Project(No.WKJ-ZJ-2415);the Key Research and Development Program of Zhejiang Province(No.2024C03166);the Traditional Chinese Medicine Science and Technology Project of Zhejiang Province(No.2022ZB020);the Zhejiang Provincial Natural Science Foundation of China(No.LY21H160049).; Numerous studies have demonstrated that the high expression of CXC motif chemokine ligand 16(CXCL16)in cancer correlates with poor prognosis,as well as tumor cell proliferation,migration,and invasion.While CXCL16 can ...; 关键词：Antioxidant pathway CXC motif chemokine ligand 16(CXCL16) Glutathione peroxidase 1(GPX1) Head and neck squamous cell carcinoma(HNSCC)

MMGCF: Generating Counterfactual Explanations for Molecular Property Prediction via Motif Rebuild: 《Journal of Computer and Communications》2025年第1期152-168,共17页Xiuping Zhang Qun Liu Rui Han; Predicting molecular properties is essential for advancing for advancing drug discovery and design. Recently, Graph Neural Networks (GNNs) have gained prominence due to their ability to capture the complex structural ...; 关键词：INTERPRETABILITY Causal Relationship Counterfactual Explanation Molecular Graph Generation

技术组合进化视角下的产品创新机会识别研究: 《情报理论与实践》2024年第12期133-142,共10页张硕李荣荣乔亚丽; 国家自然科学基金青年项目“生物医学领域新兴主题的识别和预测方法研究”(项目编号:72104246);国家自然科学基金青年项目“颠覆性低碳技术识别及创新路径动态选择研究”(项目编号:72304023);中国博士后科学基金面上项目“基于多数据源融合的颠覆性低碳技术演化路径识别与预测研究”(项目编号:2023M730153);中国博士后科学基金面上项目“全球科创中心高端科技人才流动的时空演化规律及形成机制研究”(项目编号:2023M741901);北京市朝阳区博士后工作经费资助项目“绿色能源领域‘卡脖子’关键核心技术甄选机制及突破路径研究”(项目编号:2023ZZ-019)的成果。; [目的/意义]如何识别具有创新性的技术组合、发挥技术间组合效应,对于企业高效开展产品创新活动具有重要价值。[方法/过程]从技术组合进化视角出发,结合SAO语义挖掘、K-Shell分解算法和网络模体算法,提出产品创新机会识别方法。首先,获...; 关键词：技术机会产品创新机会文本挖掘 SAO语义挖掘 Motif结构

Targeting neuronal PAS domain protein 2 and KN motif/ankyrin repeat domains 1:Advances in type 2 diabetes therapy: 《World Journal of Diabetes》2024年第11期2173-2176,共4页Chun-Han Cheng Wen-Rui Hao Tzu-Hurng Cheng; This editorial summarizes the latest literature on the roles of neuronal PAS domain protein 2 and KN motif/ankyrin repeat domain 1 in type 2 diabetes(T2D).We highlight their involvement inβ-cell dysfunction,explore t...; 关键词：Type 2 diabetes Neuronal PAS domain protein 2 KN motif and ankyrin repeat domain 1 β-cell dysfunction Therapeutic target

CXCL10 Induces Lytic Reactivation of EBV through EXTL1: 《Advances in Bioscience and Biotechnology》2024年第10期621-635,共15页Bei-Ning Ding Yi-Lin Wu You-Yu Zhang Yong-Guo Li; Epstein-Barr virus (EBV) infects over 90% of the global population, establishing latent infections in most individuals. Under specific conditions like inflammation and immune suppression, EBV can be reactivated, leadi...; 关键词：Epstein-Barr Virus REACTIVATION Inflammation Chemokine (C-X-C Motif) Ligand 10 EXTL1

Identification of a novel caspase cleavage motif AEAD: 《Virologica Sinica》2024年第5期755-766,共12页Yujie Fang Zhou Gong Miaomiao You Ke Peng; supported by the National Key R&D Program of China(2021YFC2300700);National Science and Technology Major Project(No.2018ZX10101004001005);National Natural Science Foundation of China(numbers 32070179).We thank Dr.Qinxue Hu(Wuhan Institute of Virology)and Dr.Yuchen Xia(Wuhan University)for help with materials.We thank Ding Gao from Center for Instrumental Analysis and Metrology at Wuhan Institute of Virology for his help with the Leica confocal microscope and the Operetta.; Infections of many viruses induce caspase activation to regulate multiple cellular pathways,including programmed cell death,immune signaling and etc.Characterizations of caspase cleavage sites and substrates are impor...; 关键词：CASPASE AEAD motif INHIBITOR VIRUS Cell death

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