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STREPTOMYCES: 作品数：427被引量：931H指数：11; 导出分析报告; 相关领域：生物学农业科学更多>>; 相关作者：鞠建华黄洪波张长生朱伟明田新朋更多>>; 相关机构：中国科学院中国科学院大学中国海洋大学江南大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划广东省自然科学基金更多>>

Harnessing the Streptomyces-originating typeⅠ-E CRISPR/Cas system for efficient genome editing in Streptomyces: 《Science China(Life Sciences)》2025年第4期1174-1182,共9页Yuhui Xie Xiaoyan Liu Tingting Wu Yunzi Luo; supported by the National Key Research and Development Program of China(2018YFA0903300);the National Natural Science Foundation of China(32071426);the KeyArea Research and Development Program of Guangdong Province(2020B0303070002);the Haihe Laboratory of Sustainable Chemical Transformations(24HHWCSS00006)。; Since their discovery,CRISPR/Cas systems have significantly expanded the genetic toolbox,aiding in the exploration and enhanced production of natural products across various microbes.Among these,class 2 CRISPR/Cas sys...; 关键词：genome editing type I-E CRISPR/Cas system STREPTOMYCES protospacer adjacent motif(PAM) identification natural product

鱼腥草内生放线菌Streptomyces sanglieri GZWMJZ-725次级代谢产物及其α-葡萄糖苷酶抑制活性研究: 《中国抗生素杂志》2025年第2期194-199,共6页李明星王立平许言超吴耽王冬阳朱伟明; 贵州省“百人领军人才”计划,中国科学院西部青年学者(院外);博士引进启动基金(No.天产自J字[2022]02号)。; 目的对鱼腥草内生链霉菌Streptomyces sanglieri GZWMJZ-725的次级代谢产物及α-葡萄糖苷酶抑制活性进行研究。方法采用大米固体培养基对菌株进行发酵;采用有机溶剂对发酵产物进行提取;利用正反相柱色谱手段对提取物进行分离纯化;综...; 关键词：内生放线菌次级代谢产物结构鉴定 Α-葡萄糖苷酶

低温耐盐碱纤维素降解菌Streptomyces microflavus CLSD-1的分离鉴定与降解条件优化: 《黑龙江八一农垦大学学报》2025年第1期96-104,共9页刘雨欣王敬红张伟洪艳华孙冬梅魏丹王伟东; 国家自然科学基金(U22A20444,32170132);黑龙江省揭榜挂帅科技攻关项目(2022ZXJ08B01);中国科学院战略性先导科技专项(XDA28030203-2);黑龙江八一农垦大学三纵计划基金(ZDZX202105)。; 寒区盐碱地纤维素微生物降解困难。获得低温耐盐碱纤维素降解菌株,提高其降解能力。从盐碱地采集土壤样品,以限制性培养筛选低温耐盐碱纤维素降解菌株,并对目标菌株进行纤维素降解能力的优化,以Plackett-Burman试验筛选得到的最佳响应...; 关键词：低温盐碱纤维素降解细黄链霉菌

刺五加内生链霉菌Streptomyces amritsarensis 13-85的次级代谢产物研究: 《中国抗生素杂志》2025年第1期22-32,共11页梁国栋苏冰洁陈渝川刘爱华王彬千晔司书毅陈明华袁丽杰; 中国医学科学院医学与健康科技创新工程经费资助(No.2021-I2M-1-028);国家自然科学基金(No.81302675);河北省自然科学基金(No.H2021209027)。; 目的研究刺五加内生链霉菌(Streptomyces amritsarensis)13-85的次级代谢产物。方法采用大孔吸附色谱、葡聚糖凝胶柱色谱、半制备高效液相等方法分离纯化菌株13-85的次级代谢产物,结合质谱和核磁共振波谱等方法确定化合物的结构;最后采...; 关键词：鼠李糖苷溶藻链霉菌刺五加内生放线菌

广西红树林放线菌Streptomyces olivaceuss 10127次级代谢产物及降糖降脂活性研究: 《热带海洋学报》2024年第6期181-189,共9页肖阳严静杨淑玉章唐桀翁杰李奇林刘洪存孟娟杨立芳; 国家自然科学基金资助项目(81960164);广西科技重大项目(AB21196020);2023年度广西少数民族预科教育基地科研项目(YJJDA202301)。; 红树林生态环境特殊,具有丰富的放线菌资源,是天然活性物质的来源之一。为获得更多具有良好生物活性的化合物,对一株来源于广西茅尾海红树林老鼠簕(Acanthus ilicifolius)根际土壤的链霉菌属放线菌Streptomyces olivaceuss 10127的次级...; 关键词：Streptomyces olivaceuss 次级代谢产物降糖活性降脂活性

Stepwise increase of fidaxomicin in an engineered heterologous host Streptomyces albus through multi-level metabolic engineering: 《Synthetic and Systems Biotechnology》2024年第4期766-774,共9页Huang Xie Yi-Ting Su Qing-Ting Bu Yue-Ping Li Qing-Wei Zhao Yi-Ling Du Yong-Quan Li; supported by the National Key R&D Program of China(grant number 2019YFA09005400);the Zhejiang Provincial Natural Science Foundation of China(grant number LQ21C010002).; The anti-Clostridium difficile infection(CDI)drug fidaxomicin is a natural polyketide metabolite mainly produced by Micromonosporaceae,such as Actinoplanes deccanensis,Dactylosporangium aurantiacum,and Micromonospora ...; 关键词：Fidaxomicin Heterologous expression Streptomyces albus Genome-reduced chassis Metabolic engineering

Functional analysis of the whole CYPome and Fdxome of Streptomyces venezuelae ATCC 15439: 《Engineering Microbiology》2024年第4期12-23,共12页Shuai Li Zhong Li Guoqiang Zhang Vlada BUrlacher Li Ma Shengying Li; This work was supported by the National Natural Science Foundation of China(32025001,32071266 and 32200017);the Shandong Provin-cial Natural Science Foundation(ZR2022QC070 and ZR2019ZD20).; Cytochrome P450 enzymes(CYPs or P450s)and ferredoxins(Fdxs)are ubiquitously distributed in all domains of life.Bacterial P450s are capable of catalyzing various oxidative reactions with two electrons usually donated b...; 关键词：STREPTOMYCES Cytochrome P450 enzymes CYPome FERREDOXIN Fdxome PikC

Quinosumycin,a novel anti-MRSA thioether-linked quinolinone-quinazolinone heterodimer from a marine actinomycete Streptomyces diastaticus NBU2966: 《Journal of Oceanology and Limnology》2024年第6期1991-1997,共7页Shuangling TAN Yang LIU Haonan FU Yutong XUE Fangjian FENG Jinling LI Xiaojun YAN Sitong WU Shan HE Lijian DING; Supported by the National Natural Science Foundation of China(No.42176101);the Ningbo Youth Science and Technology Innovation Leading Project(No.2024QL063);the National 111 Project of China(No.D16013);the Scientific Research Fund of Zhejiang Provincial Education Department(No.Y202250186);the Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Development Fund。; Marine natural products offer a promising source in the development of new antibiotic drugs.Two previously undescribed compounds,including one sulfur-bearing alkaloid named quinosumycin(1)along with one chromone deriv...; 关键词：marine natural product marine Streptomyces THIOETHER alkaloid HETERODIMER anti-methicillinresistant Staphylococcus aureus(anti-MRSA)

Rational construction of genome-minimized Streptomyces host for the expression of secondary metabolite gene clusters: 《Synthetic and Systems Biotechnology》2024年第3期600-608,共9页Hui Li Sheng Gao Sanyuan Shi Xiaomin Zhao Haoyu Ye Yunzi Luo; supported by the National Key Research and Development Program of China(Grant No.2018YFA0903300);the National Natural Science Foundation of China(Grant No.32071426);the Key-Area Research and Development Program of Guangdong Province(2020B0303070002);the Haihe Laboratory of Sustainable Chemical Transformations.; Streptomyces offer a wealth of naturally occurring compounds with diverse structures,many of which possess significant pharmaceutical values.However,new product exploration and increased yield of specific compounds in...; 关键词：STREPTOMYCES Chassis engineering CRISPR Natural products Synthetic biology

Antibacterial and cytotoxic metabolites produced by Streptomyces tanashiensis BYF-112 isolated from Odontotermes formosanus: 《Chinese Journal of Natural Medicines》2024年第9期822-830,共9页WU Jun SONG Tao ZHANG Le HUANG Zhongdi HUANG Fang YIN Caiping ZHANG Shuxiang LIU Xinhua ZHANG Yinglao; supported by the Natural Science Funds for Distinguished Young Scholars of Anhui Province(No. 2108085J18);the National Natural Science Foundation of China (Nos. 32011540382 and 32102272)。; Chemical investigations of the termite-associated Streptomyces tanashiensis BYF-112 resulted in the discovery of four novel alkaloid derivatives: vegfrecines A and B(1 and 2), exfoliazone A(3), and venezueline H(7), i...; 关键词：Odontotermes formosanus Streptomyces tanashiensis ALKALOID Cytotoxic activity Antibacterial activity Biosynthetic pathway

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