HETERODIMER

作品数：26被引量：32H指数：4
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相关领域：医药卫生生物学更多>>
相关作者：吴战宏更多>>
相关机构：北京协和医院中国科学院遗传与发育生物学研究所更多>>
相关期刊：《Bioactive Materials》《iRADIOLOGY》《Tsinghua Science and Technology》《Journal of Oceanology and Limnology》更多>>
相关基金：国家自然科学基金高等学校学科创新引智计划更多>>
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Utilizing bivalent aptamers as first DNA agonist to activate RTKs heterodimer of different families
《Chinese Chemical Letters》2025年第1期474-477,共4页Kun Liu Yulin Cong Xiongfeng Luo Meicun Yao Zhiyong Xie Hao Li 
the National Natural Science Foundation of China(Nos.22104158,82174104,U1903211);the Natural Science Foundation of Hunan Province(No.2021JJ40041);Guangdong Basic and Applied Basic Research Foundation(No.2023A1515011346);Shenzhen Science and Technology Program(No.SZBH202130)。
Heterodimerization in RTKs is of vital importance in the RTK signaling and cell functions.Heterodimerization between RTKs can result in diversity of downstream signals,increasing the ability of cells to respond to ext...
关键词：DNA Agonist Bivalent aptamers RTKs heterodimer 
Quinosumycin,a novel anti-MRSA thioether-linked quinolinone-quinazolinone heterodimer from a marine actinomycete Streptomyces diastaticus NBU2966
《Journal of Oceanology and Limnology》2024年第6期1991-1997,共7页Shuangling TAN Yang LIU Haonan FU Yutong XUE Fangjian FENG Jinling LI Xiaojun YAN Sitong WU Shan HE Lijian DING 
Supported by the National Natural Science Foundation of China(No.42176101);the Ningbo Youth Science and Technology Innovation Leading Project(No.2024QL063);the National 111 Project of China(No.D16013);the Scientific Research Fund of Zhejiang Provincial Education Department(No.Y202250186);the Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Development Fund。
Marine natural products offer a promising source in the development of new antibiotic drugs.Two previously undescribed compounds,including one sulfur-bearing alkaloid named quinosumycin(1)along with one chromone deriv...
关键词：marine natural product marine Streptomyces THIOETHER alkaloid HETERODIMER anti-methicillinresistant Staphylococcus aureus(anti-MRSA) 
Cucurbit[8]uril-based non-covalent heterodimer realized NIR cell imaging through topological transformation from nanowire to nanorod
《Chinese Chemical Letters》2024年第10期262-268,共7页Jianqiu Li Yi Zhang Songen Liu Jie Niu Rong Zhang Yong Chen Yu Liu 
National Natural Science Foundation of China(Nos.22131008 and 21971127);the Fundamental Research Funds for the Central Universities;the Haihe Laboratory of Sustainable Chemical Transformations for financial support。
In recent years,multicolor cascade supramolecular assemblies with controllable topological morphology have become a research hotspot due to their wide application in light-emitting materials,cell imaging and other fie...
关键词：Multivalent assemblies CUCURBITURIL Morphological transformation Targeted imaging 
Highly Aromatic Norditerpenoid Heterodimers and Monomers from Trigonostemon fragilis
《Engineering》2024年第7期144-154,共11页Jun-Su Zhou Long Cheng Yuan Gao Zhan-Peng Ge Bin Zhou Jing-Ya Li Jin-Xin Zhao Jian-Min Yue 
support from the National Natural Science Foundation of China(22237007 and 22177122);the Biological Resources Program of Chinese Academy of Sciences(CAS)(KFJ-BRP-008-001);the Youth Innovation Promotion Association of Chinese Academy of Sciences(2022282)is gratefully acknowledged.We thank Prof.Shi-Man Huang,Department of Biology,Hainan University,China,for the identification of the plant material.
Four new norditerpenoid heterodimers with different dimerization patterns-namely,trigofragiloids A-C(denoted as compounds 1-3)and(+)-and(-)-trigofragiloid D(compound 4)-and three new phenanthrenone norditerpenoids-nam...
关键词：Norditerpenoid heterodimer Trigonostemon fragilis EUPHORBIACEAE Trigofragiloid Structural revision Adenosine triphosphate-citrate lyase(ACLY) inhibitory activity 
Elevating theranostics:The emergence and promise of radiopharmaceutical cell-targeting heterodimers in human cancers
《iRADIOLOGY》2024年第2期128-155,共28页Claudia Chambers Broc Chitwood Charles J.Smith Yubin Miao 
NIH Research Evaluation and Commercilization Hub,Grant/Award Number:1U01HL152410;USVA Medical Research Service,Grant/Award Number:I01 BX00096409;National Institutes of Health,Grant/Award Numbers:R01CA269221,R01CA225837。
Optimal therapeutic and diagnostic efficacy is essential for healthcare's global mission of advancing oncologic drug development.Accurate diagnosis and detection are crucial prerequisites for effective risk stratifica...
关键词：HETERODIMER heterobivalent hybrid peptide PSMA GRPR ΑVΒ3 SST MSH 
Metformin:A promising clinical therapeutical approach for BPH treatment via inhibiting dysregulated steroid hormones-induced prostatic epithelial cells proliferation被引量：2
《Journal of Pharmaceutical Analysis》2024年第1期52-68,共17页Tingting Yang Jiayu Yuan Yuting Peng Jiale Pang Zhen Qiu Shangxiu Chen Yuhan Huang Zhenzhou Jiang Yilin Fan Junjie Liu Tao Wang Xueyan Zhou Sitong Qian Jinfang Song Yi Xu Qian Lu Xiaoxing Yin 
supported by the National Natural Science Foundation of China(Grant Nos.:81973377,81903689,82073906 and 82273987);the Key Natural Science Foundation of Jiangsu Higher Education Institutions of China(Grant Nos.:19KJB350006 and 19KJA460008);Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),the initializing Fund of Xuzhou Medical University(Grant No.:D2018011);Postgraduate Research Practice Innovation Program of Jiangsu Province(Grant Nos.:KYCX21-2733 and KYCX22-2966).
The occurrence of benign prostate hyperplasia(BPH)was related to disrupted sex steroid hormones,and metformin(Met)had a clinical response to sex steroid hormone-related gynaecological disease.However,whether Met exert...
关键词：METFORMIN Benign prostatic hyperplasia Sex steroid hormones homeostasis PROLIFERATION DHT YAP1-TEAD4 heterodimer 
Steering G protein activation by mGlu heterodimer
《Cell Research》2023年第10期735-736,共2页Guillaume Lebon 
Heterodimerization of metabotropic glutamate receptors(mGlus)generates functional units that modulate the synapse activity,and displays strong therapeutic potential for treating brain disorders and psychiatry diseases...
关键词：al. ACTIVATION RATIONAL 
Src heterodimerically activates Lyn or Fyn to serve as targets for the diagnosis and treatment of esophageal squamous cell carcinoma被引量：3
《Science China(Life Sciences)》2023年第6期1245-1263,共19页Jing Zhang Di Zhao Lingyuan Zhang Yuanfan Xiao Qingnan Wu Yan Wang Jie Chen Qimin Zhan 
supported by the National Natural Science Foundation of China (81988101,81830086 and 81972243);CAMS Innovation Fund for Medical Sciences (2019-I2M-5-081);Major Program of Shenzhen Bay Laboratory (S201101004);Guangdong Basic and Applied Basic Research Foundation (2019B030302012);the Fund of“San-ming”Project of Medicine in Shenzhen (SZSM201812088)。
Although Src is one of the oldest and most investigated oncoproteins,its function in tumor malignancy remains to be defined further.In this study,we demonstrated that the inhibition of Src activity by ponatinib effect...
关键词：esophageal squamous cell carcinoma HETERODIMER Src-family kinase SRC tyrosine phosphorylation 
Active spatial control of photothermal heating and thermo-actuated convective flow by engineering a plasmonic metasurface with heterodimer lattices
《Photonics Research》2022年第11期2642-2657,共16页ZHIMIN JING PEIHANG LI CUIPING MA JIAYING WANG ROBERTO CAPUTO ALEXANDER OGOVOROV ARUP NEOGI HONGXING XU ZHIMING WANG 
111 Project(B20030);National Natural Science Foundation of China(62075034);National Key Research and Development Program of China(2019YFB2203400)。
Thermo-plasmonics, using plasmonic structures as heat sources, has been widely used in biomedical and microfluidic applications. However, a metasurface with single-element unit cells, considered as the sole heat sourc...
关键词：EXCITATION reversed flow 
Germline Deletion of the Expression of a Human Bispecific Mucosal Immunoglobulin: Genetic Predisposition to Cancer and Communicable Diseases Predominantly among African-Americans
《Open Journal of Preventive Medicine》2021年第10期383-390,共8页Padmanabhan Nair 
In a previous report we had reported on the discovery of a novel bispecific immunoglobulin expressed by colonic epithelial cells as they transform into immunomimetic cells during exfoliation (Albaugh et al. (2...
关键词：Colon Epithelial Cells IgA/IgG Bi-Specific Immunoglobulin ONCOLYSIS Anti-Infective Firewall HETERODIMER Gastrointestinal Progenitor Cells (GIP-C†) 
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