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Autophagy-targeting modulation to promote peripheral nerve regeneration: 《Neural Regeneration Research》2025年第7期1864-1882,共19页Yan Chen Hongxia Deng Nannan Zhang; supported by the National Natural Science Foundation of China,Nos.82271411(to RG),51803072(to WLiu);grants from the Department of Finance of Jilin Province,Nos.2022SCZ25(to RG),2022SCZ10(to WLiu),2021SCZ07(to RG);Jilin Provincial Science and Technology Program,No.YDZJ202201ZYTS038(to WLiu);The Youth Support Programmed Project of China-Japan Union Hospital of Jilin University,No.2022qnpy11(to WLuo);The Project of China-Japan Union Hospital of Jilin University,No.XHQMX20233(to RG)。; Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular mechanisms.Past studies have focused on factors that stimulat...; 关键词：AUTOPHAGY autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy METFORMIN MYELINATION peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

Anemia risk and mitigation strategies in type 2 diabetic patients:The role of novel antidiabetic agents: 《World Journal of Diabetes》2025年第5期119-123,共5页Petra Meliš Maja Cigrovski Berkovic; Anemia is a common yet often overlooked complication in patients with type 2 diabetes mellitus(T2DM),particularly those with chronic kidney disease.It significantly impacts patients'quality of life,cardiovascular heal...; 关键词：ANEMIA Type 2 diabetes mellitus chronic kidney disease Iron deficiency METFORMIN Sodium-glucose cotransporter-2 inhibitors Glucagon-like peptide-1 receptor agonist Glucagon-like peptide-1 receptor agonist/GIP dual agonists

Exploration of metformin-based drug combination for mitigating diabetes-associated atherosclerotic diseases: 《World Journal of Diabetes》2025年第4期304-309,共6页Biao Qu Zheng Li Wei Hu; Supported by the Natural Science Research Project of Anhui Province,No.2023AH053172;National Natural Science Foundation of Anhui Province,No.2408085QH260;Projects of Administration of Traditional Chinese Medicine of Anhui Province,No.2024CCCX082;National Natural Science Foundation Incubation Program of The Second Hospital of Anhui Medical University,No.2022GMFY08.; Diabetes mellitus is a substantial global health threat due to its high prevalence and its serious complications.The hyperglycemic state causes damage to vascular endothelial cells and disturbance of lipid metabolism,...; 关键词：Diabetes Atherosclerotic diseases METFORMIN Drug combination Hypoglycemic agent Hypolipidemic agent Antioxidant agent

Plantamajoside mitigates endoplasmic reticulum stress-mediated pancreatic β-cell apoptosis in type 2 diabetes via DNAJC1 upregulation: 《World Journal of Diabetes》2025年第4期318-325,共8页Md Abdul Alim Al-Bari Fabian Davamani Payal Bhatnagar Nabil Eid; Diabetes mellitus(DM)is a metabolic disorder characterized by persistent hyperglycemia and other symptoms,which pose significant challenges to individual health,life expectancy,and public healthcare systems.The escala...; 关键词：Plantamajoside Type 2 diabetes mellitus PI3K/AKT/NF-κB pathway Endoplasmic stress METFORMIN DNAJC1 Apoptosis AUTOPHAGY

Quercetin mitigates hepatic injury by inhibiting TGF-β/p-Smad3 signaling pathway activation and enhancing AMPK activity in type 2 diabetic rats: 《Asian Pacific Journal of Tropical Biomedicine》2025年第4期150-157,共8页Hanaa F.B.Gaber Mohamed K.Mahfouz Fatma SM Moawed Esraa SA Ahmed Omayma AR Abo-Zaid; Objective:To investigate the effects of quercetin on inflammatory signaling pathways and hepatic oxidative injury using a streptozotocin-induced liver injury model.Methods:Four groups of 32 rats were used in this stud...; 关键词：QUERCETIN METFORMIN STREPTOZOTOCIN Liver injury TGF-β/Smad signaling AMPK SREBP1c

Diabetes and Hypertension: 《Journal of Diabetes Mellitus》2025年第1期25-39,共15页Mounika Vejendla Meghana Anagani Terry Oroszi; Diabetes mellitus and hypertension are two of the most prevalent diseases affecting individuals across all age groups. Both conditions are linked to an increased risk of heart disease, peripheral vascular disease, str...; 关键词：DIABETES METFORMIN HYPERTENSION Blood Glucose Levels INSULIN Blood Pressure

Enhancing metformin efficacy with cholecalciferol and taurine in diabetes therapy:Potential and limitations: 《World Journal of Diabetes》2025年第1期22-26,共5页Gehan El-Akabawy Nabil Eid; Diabetes mellitus,particularly type 2 diabetes mellitus(T2DM),poses a significant global health challenge.Traditional management strategies primarily focus on glycemic control;however,there is a growing need for compr...; 关键词：Diabetes METFORMIN CHOLECALCIFEROL TAURINE HYPERGLYCEMIA Oxidative stress TRIGLYCERIDES

Exploring the anti-osteoporotic potential of simvastatin and metformin: a comprehensive Mendelian randomization and animal experiment investigation: 《Biomedical Engineering Communications》2024年第4期29-38,共10页Hui Zhou Jin Zhang Pei-Pei He Yu Gou Xun Sun He-Tong Li; funded by the Applied Basic Research Foundation of Tianjin(22JCQNJC00230);the Beijing-Tianjin-Hebei Basic Research Cooperation Project(23JCZXJC00050/J230007);the Tianjin Health and Technology Project(TJWJ2024QN056)。; Background:Both simvastatin and metformin have demonstrated potential efficacy in osteoporosis(OP)treatment.However,there is a lack of systematic studies comparing their anti-osteoporotic effects.This study aims to co...; 关键词：senile osteoporosis Mendelian randomization animal study SIMVASTATIN METFORMIN

Metformin:decelerates biomarkers of aging clocks: 《Signal Transduction and Targeted Therapy》2024年第12期5359-5360,共2页Ram Abou Zaki Assam El-Osta; NHMRC Clinical Trials and Cohort Studies Grant(APP2014763);fellowship from the NHMRC for 1154650;funded through a strategic research agreement with JDRF International(grant 2-SRA-2024-1442-S-B);support from a grant provided by the Danish Diabetes Academy to A.E.O.,which is financed by the Novo Nordisk Foundation(grant NNF17SA0031406).; A recent study published in Cell shows the widely known and used antidiabetic drug metformin,has geroprotective benefits in nonhuman male primates.1 Metformin is a derivative of biguanide,synthesized in the 1920s and ...; 关键词：protective METFORMIN AGING

Impact of alcoholic extract from sea cucumber(Holothuria parva)on letrozole-induced polycystic ovary syndrome in adult female rats: 《Asian pacific Journal of Reproduction》2024年第6期261-270,共10页Samaneh Askari Mohammad Reza Jafarzadeh Shirazi Masoumeh Ahmadi Arezoo Khoradmehr Nadiar M.Mussin Asset A.Kaliyev Farzad Mohammad Rezazadeh Mohammad Dadpasand Taromsari Ali Bustani Nader Tanideh Kulyash R.Zhilisbayeva Amin Tamadon; supported by Shiraz University,Vice-Chancellor of Research as a master thesis.; Objective:To explore the potential therapeutic impact of an alcoholic extract derived from the sea cucumber(Holothuria parva)on letrozole-induced polycystic ovary syndrome(PCOS)in adult female Sprague-Dawley rats.Meth...; 关键词：Polycystic ovary syndrome Sea cucumber LETROZOLE METFORMIN RATS

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