Autophagy-targeting modulation to promote peripheral nerve regeneration  

作　　者：Yan Chen Hongxia Deng Nannan Zhang 

机构地区：[1]Department of Obstetrics and Gynecology,West China Second Hospital,Sichuan University,Chengdu,Sichuan Province,China [2]Key Laboratory of Birth Defects and Women and Children’s Diseases,Ministry of Education,Sichuan University,Chengdu,Sichuan Province,China [3]Laboratory of Reproductive Endocrinology and Reproductive Regulation,Sichuan University,Chengdu,Sichuan Province,China [4]National Center for Birth Defect Monitoring,West China Second University Hospital,Sichuan University,Chengdu,Sichuan Province,China

出　　处：《Neural Regeneration Research》2025年第7期1864-1882,共19页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos.82271411(to RG),51803072(to WLiu);grants from the Department of Finance of Jilin Province,Nos.2022SCZ25(to RG),2022SCZ10(to WLiu),2021SCZ07(to RG);Jilin Provincial Science and Technology Program,No.YDZJ202201ZYTS038(to WLiu);The Youth Support Programmed Project of China-Japan Union Hospital of Jilin University,No.2022qnpy11(to WLuo);The Project of China-Japan Union Hospital of Jilin University,No.XHQMX20233(to RG)。

摘　　要：Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular mechanisms.Past studies have focused on factors that stimulate axonal outgrowth and myelin regeneration.However,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic injuries.Consequently,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve regeneration.Our current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and inflammation.These actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve injuries.This review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this process.We hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关 键 词：AUTOPHAGY autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy METFORMIN MYELINATION peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration 

分 类 号：R745[医药卫生—神经病学与精神病学]