STREPTOZOTOCIN

作品数：168被引量：602H指数：14
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Quercetin mitigates hepatic injury by inhibiting TGF-β/p-Smad3 signaling pathway activation and enhancing AMPK activity in type 2 diabetic rats
《Asian Pacific Journal of Tropical Biomedicine》2025年第4期150-157,共8页Hanaa F.B.Gaber Mohamed K.Mahfouz Fatma SM Moawed Esraa SA Ahmed Omayma AR Abo-Zaid 
Objective:To investigate the effects of quercetin on inflammatory signaling pathways and hepatic oxidative injury using a streptozotocin-induced liver injury model.Methods:Four groups of 32 rats were used in this stud...
关键词：QUERCETIN METFORMIN STREPTOZOTOCIN Liver injury TGF-β/Smad signaling AMPK SREBP1c 
Proximal small intestinal bypass outperforms Roux-en-Y and jejunoileal bypass in glucose regulation in streptozotocin induced diabetic rats
《World Journal of Gastrointestinal Surgery》2025年第2期237-246,共10页Chi-Ying Xu Cai Tan Xin Luo Kun Yang Ren-Ran Wu Lei Lin Guan-Lei Liu Jin-Yuan Duan 
Supported by National Natural Science Foundation of China,No.82360168 and No.81960154;Natural Science Foundation of Jiangxi Province,No.20212BAB206020;the Foundation of Health Commission of Jiangxi Province,No.SKJP220225830.
BACKGROUND The efficacy of various bariatric surgeries varies in reducing blood glucose levels.Given the distinct mechanisms and anatomical alterations associated with each procedure,it is crucial to compare their gly...
关键词：Bariatric surgery DIABETES Glucose control Proximal small intestinal bypass Roux-en-Y gastric bypass Jejunoileal bypass 
Assessment of ameliorative effects of Moringa oleifera Lam. on epididymal dysfunctions and fertility in streptozotocin-induced diabetic rats
《Asian pacific Journal of Reproduction》2024年第6期271-280,共10页Ram Niwas Jangir Gyan Chand Jain 
Objective:To assess the protective effects of 70%ethanolic extract of Moringa(M.)oleifera leaves on fertility and epididymal dysfunctions in diabetic rats.Methods:Thirty-six male Wistar rats were divided into six grou...
关键词：ANTIOXIDANTS EPIDIDYMIS FERTILITY Moringa oleifera Sperm parameters STREPTOZOTOCIN 
Modified streptozotocin-induced diabetic model in rodents
《Animal Models and Experimental Medicine》2024年第5期777-780,共4页Anton Lennikov Farris ElZaridi Menglu Yang 
Streptozotocin(STZ)-induced type I diabetes mellitus(DM)models have been pivotal in diabetes research due to their ability to mimic the insulin-dependent hyperglyce-mia akin to human type I diabetes.However,these mode...
关键词：HYPERGLYCEMIA non- FASTING STREPTOZOTOCIN Type 1 diabetes mellitus 
Veratrilla baillonii Franch alleviate the symptoms of diabetes in type 2 diabetic rats induced by high-fat diet and streptozotocin
《Food Science and Human Wellness》2024年第3期1378-1389,共12页Chunlan Yan Zhihao Zhang Liqun Ma Xinyi Xu Muhammad Azhar Xianju Huang Jianxun Shi Jun Li 
supported by grants from the National Natural Science Foundation of China (81873090);Support Innovation and Development of Enterprise Technology Projects in Hubei Province (2021BLB174);the modern transmission and innovation research team of Traditional Chinese Medicine,South Central Minzu University。
Our previous research studies have shown that Veratrilla baillonii Franch,a food supplement used by ethnic minorities in Southwest China,has multiple pharmacological activities,such as detoxification,antiinflammatory,...
关键词：Veratrilla baillonii Franch Type 2 diabetes mellitus Liver injury Skeletal muscle GLUT4 
Genetic lineage tracing identifies adaptive mechanisms of pancreatic islet β cells in various mouse models of diabetes with distinct age of initiation被引量：1
《Science China(Life Sciences)》2024年第3期504-517,共14页Qi Fu Yu Qian Hemin Jiang Yunqiang He Hao Dai Yang Chen Zhiqing Xia Yucheng Liang Yuncai Zhou Rui Gao Shuai Zheng Hui Lv Min Sun Kuanfeng Xu Tao Yang 
supported by the National Natural Science Foundation of China(81830023,82070803,82100838,82100837,81900708)。
During the pathogenesis of type 1 diabetes(T1D) and type 2 diabetes(T2D), pancreatic islets, especially the β cells, face significant challenges. These insulin-producing cells adopt a regeneration strategy to compens...
关键词：islet regeneration lineage tracing high fat diet(HFD) streptozotocin(STZ) 
Hepatic and renal effects of oral stingless bee honey in a streptozotocin-induced diabetic rat model
《World Journal of Experimental Medicine》2024年第1期113-123,共11页Suriati Mohd Nasir Anis Farihan Ismail Tuan Salwani Tuan Ismail Wan Faiziah Wan Abdul Rahman Wan Amir Nizam Wan Ahmad Tengku Ahmad Damitri Al-Astani Tengku Din Kuttulebbai Nainamohammed Salam Sirajudeen 
Ministry of Higher Education,Malaysia for Fundamental Research Grant Scheme FRGS/1/2019/SKK06/USM/03/6,No.291983-329281.
BACKGROUND Diabetes is known damage the liver and kidney,leading to hepatic dysfunction and kidney failure.Honey is believed to help in lowering the blood glucose levels of diabetic patients and reducing diabetic comp...
关键词：Diabetes STREPTOZOTOCIN Stingless bee honey Hematoxylin and eosin Periodic acid-Schiff Liver Kidney 
Surfactin alleviated hyperglycaemia in mice with type 2 diabetes induced by a high-fat diet and streptozotocin
《Food Science and Human Wellness》2023年第6期2095-2110,共16页Xiaoyu Chen Hongyuan Zhao Fanqiang Meng Libang Zhou Zhaoxin Lu Yingjian Lu 
supported by the National Natural Science Foundation of China(32072182)。
Type 2 diabetes mellitus(T2DM)is associated with liver dysfunction and intestinal dysbiosis.Bioactive peptides(BAPs)have been reported to ameliorate T2DM by preventing oxidative damage to the liver.Bacillus amylolique...
关键词：SURFACTIN Type 2 diabetes mellitus(T2DM) Insulin resistance Gut microbiota Glucose metabolism 
Evaluation of the Key Mechanism Justifying the High Sensitivity of Obese Rodents to Treptozotocin (STZ)
《Journal of Biosciences and Medicines》2023年第12期376-394,共19页Ngounou Eleonore Rochelle Van Wijk Hermann Ngouakam 
Diabetes mellitus (DM) is a metabolic disease caused by the absence or dysfunction of insulin;a hormone secreted by the pancreatic beta cell (β-cell) whenever blood glucose exceeds the normal physiological value. The...
关键词：STREPTOZOTOCIN High-Fat Diet OBESITY Sensitivity 
Acute and Prolonged Effects of a Polyherbal Formulation on Blood Glucose, Lipid Profile and Liver Function in Normal and Streptozotocin-Induced Diabetic Rats
《Journal of Biosciences and Medicines》2023年第11期277-302,共26页Marie Claire Tchamadeu Hélène Elena Ndame Calvin Zangueu Bogning Modeste Wankeu-Nya Patience Emambo Olga Sol Fonga Christian Takoukam Tenezogang Alain Bertrand Dongmo Siméon Pierre Choukem 
Background: Few studies have often focused on medicinal plant mixtures, yet the most used in low-and middle-income areas as alternative drug to treat diseases. Objective: To evaluate the antidiabetic effects of Emilia...
关键词：Emilia coccinea Scoparia dulcis Tetracarpidium conophorum Traditional Medicinal Potion Diabetes Mellitus STREPTOZOTOCIN 
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