Acute and Prolonged Effects of a Polyherbal Formulation on Blood Glucose, Lipid Profile and Liver Function in Normal and Streptozotocin-Induced Diabetic Rats  

作　　者：Marie Claire Tchamadeu Hélène Elena Ndame Calvin Zangueu Bogning Modeste Wankeu-Nya Patience Emambo Olga Sol Fonga Christian Takoukam Tenezogang Alain Bertrand Dongmo Siméon Pierre Choukem Marie Claire Tchamadeu;Hélène Elena Ndame;Calvin Zangueu Bogning;Modeste Wankeu-Nya;Patience Emambo;Olga Sol Fonga;Christian Takoukam Tenezogang;Alain Bertrand Dongmo;Siméon Pierre Choukem(Department of Biology and Physiology of Animal Organisms, Faculty of Science, University of Douala, Douala, Cameroon;Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon)

机构地区：[1]Department of Biology and Physiology of Animal Organisms, Faculty of Science, University of Douala, Douala, Cameroon [2]Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon

出　　处：《Journal of Biosciences and Medicines》2023年第11期277-302,共26页生物科学与医学（英文）

摘　　要：Background: Few studies have often focused on medicinal plant mixtures, yet the most used in low-and middle-income areas as alternative drug to treat diseases. Objective: To evaluate the antidiabetic effects of Emilia coccinea (Ec) (Asteraceae), Scoparia dulcis (Sd) (Plantaginaceae) and Tetracarpidium conophorum (Tc) (Euphorbiaceae) aqueous extracts mixture (EcSdTc) in rats. Methodology: Single plant aqueous extracts (Ec, Sd and Tc) and their mixtures (EcSd, EcTc, SdTc and EcSdTc) (each at the doses of 125 and 250 mg/kg body weight respectively) were evaluated in acute administration on blood glucose in normal, glucose-overloaded and diabetic rats;then EcSdTc mixture was assessed in prolonged administration (21 days) on blood glucose, body weight, serum biochemical and antioxidant parameters in diabetic rats. Diabetes was induced by single intraperitoneal administration of streptozotocin (STZ;50 mg/kg), and glibenclamide (10 mg/kg) was used as standard drug. Results: In acute administration, EcTc250, EcSdTc125, SdTc250, SdTc125, EcSd250, and EcSdTc250 extracts mixtures reduced (p Conclusion: EcSdTc aqueous extracts mixture has potent hypoglycemic and antidiabetic effects, probably due to their bioactive compounds synergistic and/or additive actions, justifying its traditional use as alternative remedies.Background: Few studies have often focused on medicinal plant mixtures, yet the most used in low-and middle-income areas as alternative drug to treat diseases. Objective: To evaluate the antidiabetic effects of Emilia coccinea (Ec) (Asteraceae), Scoparia dulcis (Sd) (Plantaginaceae) and Tetracarpidium conophorum (Tc) (Euphorbiaceae) aqueous extracts mixture (EcSdTc) in rats. Methodology: Single plant aqueous extracts (Ec, Sd and Tc) and their mixtures (EcSd, EcTc, SdTc and EcSdTc) (each at the doses of 125 and 250 mg/kg body weight respectively) were evaluated in acute administration on blood glucose in normal, glucose-overloaded and diabetic rats;then EcSdTc mixture was assessed in prolonged administration (21 days) on blood glucose, body weight, serum biochemical and antioxidant parameters in diabetic rats. Diabetes was induced by single intraperitoneal administration of streptozotocin (STZ;50 mg/kg), and glibenclamide (10 mg/kg) was used as standard drug. Results: In acute administration, EcTc250, EcSdTc125, SdTc250, SdTc125, EcSd250, and EcSdTc250 extracts mixtures reduced (p Conclusion: EcSdTc aqueous extracts mixture has potent hypoglycemic and antidiabetic effects, probably due to their bioactive compounds synergistic and/or additive actions, justifying its traditional use as alternative remedies.

关 键 词：Emilia coccinea Scoparia dulcis Tetracarpidium conophorum Traditional Medicinal Potion Diabetes Mellitus STREPTOZOTOCIN 

分 类 号：R58[医药卫生—内分泌]