Veratrilla baillonii Franch alleviate the symptoms of diabetes in type 2 diabetic rats induced by high-fat diet and streptozotocin  

作　　者：Chunlan Yan Zhihao Zhang Liqun Ma Xinyi Xu Muhammad Azhar Xianju Huang Jianxun Shi Jun Li 

机构地区：[1]College of Life Sciences,South-Central Minzu University,Wuhan 430074,China [2]College of Pharmaceutical Science,South-Central Minzu University,Wuhan 430074,China [3]Department of Biosciences,COMSATS University Islamabad,Sahiwal 57000,Pakistan [4]Zhejiang Pharmaceutical University,Ningbo 315100,China [5]Ethnopharmacology Level 3 Laboratory,National Administration of Traditional Chinese Medicine,South-Central Minzu University,Wuhan 430074,China

出　　处：《Food Science and Human Wellness》2024年第3期1378-1389,共12页食品科学与人类健康（英文）

基　　金：supported by grants from the National Natural Science Foundation of China (81873090);Support Innovation and Development of Enterprise Technology Projects in Hubei Province (2021BLB174);the modern transmission and innovation research team of Traditional Chinese Medicine,South Central Minzu University。

摘　　要：Our previous research studies have shown that Veratrilla baillonii Franch,a food supplement used by ethnic minorities in Southwest China,has multiple pharmacological activities,such as detoxification,antiinflammatory,antioxidant,and anti-insulin resistance.However,the detailed signal pathways for its salutary effect on damages in multiple organs due to type 2 diabetes mellitus(T2DM)remains unclear.The current study is to evaluate the therapeutic effects of V.baillonii on T2DM rats and to explore the underlying mechanisms.The T2DM rat model was successfully established by a high-sugar and high-fat diet(HFD)combination with intraperitoneal injection of a small dose of streptozotocin(STZ,35 mg/kg).Biochemical analysis and histopatholgical examinations were conducted to evaluate the anti-diabetic potential of water extracts of V.baillonii(WVBF).The results showed that the WVBF treatment can improve hyperglycemia and insulin resistance,ameliorate the liver,kidney and pancreas injuries via decreasing inflammatory cytokines such as IL-6 and TNF-α,and oxidative damages.Further investigation suggested that WVBF modulates the signal transductions of the IRS1/PI3K/AKT/GLUT4 and AMPK pathways.These findings demonstrate potentials of WVBF in the treatment of T2DM and possible mechanisms for its hepatoprotective activities.

关 键 词：Veratrilla baillonii Franch Type 2 diabetes mellitus Liver injury Skeletal muscle GLUT4 

分 类 号：TS201.4[轻工技术与工程—食品科学]