SIMVASTATIN

作品数：146被引量：355H指数：10
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相关机构：大连医科大学苏州大学吉林大学大连医科大学附属第二医院更多>>
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Exploring the anti-osteoporotic potential of simvastatin and metformin: a comprehensive Mendelian randomization and animal experiment investigation
《Biomedical Engineering Communications》2024年第4期29-38,共10页Hui Zhou Jin Zhang Pei-Pei He Yu Gou Xun Sun He-Tong Li 
funded by the Applied Basic Research Foundation of Tianjin(22JCQNJC00230);the Beijing-Tianjin-Hebei Basic Research Cooperation Project(23JCZXJC00050/J230007);the Tianjin Health and Technology Project(TJWJ2024QN056)。
Background:Both simvastatin and metformin have demonstrated potential efficacy in osteoporosis(OP)treatment.However,there is a lack of systematic studies comparing their anti-osteoporotic effects.This study aims to co...
关键词：senile osteoporosis Mendelian randomization animal study SIMVASTATIN METFORMIN 
Simvastatin enhanced growth and altered testis transcriptome profiles of male tilapias
《Aquaculture and Fisheries》2024年第6期893-899,共7页Zituo Yang Fei Sun Le Wang Gen Hua Yue 
supported by the internal fund of the Temasek Life Sciences Laboratory,Singapore.
Simvastatin(SIM),a commonly prescribed drug for lowering serum-lipid,has been detected in many aquatic environments.Exposure to high concentrations of SIM in rats and aquatic organisms resulted in toxicity to hepatocy...
关键词：Fish STATIN GROWTH Reproduction AQUACULTURE 
Optimization of variables and assessment of in-vitro and in-vivo antihyperlipidemic activity of Eudragit RS nanoparticles containing simvastatin
《Particuology》2024年第7期189-198,共10页Bina Gidwani Vishal Jain Veenu Joshi Ravindra Kumar Pandey Shiv Shankar Shukla Amber Vyas 
the Department of Science and Technology(DST-FIST)Letter no-SR/FST/COLLEGE/2018/418;New Delhi for providing financial assistance.The authors AV acknowledge the Department of Science and Technology,New Delhi,India(DST/INSPIRE Fellowship/2019/IF190329 and DST/NM/NT/2018/20)for providing financial assistance for the successful completion of this work.
Simvastatin, a BCS class II drug, is associated with poor aqueous solubility, first-pass metabolism and short half-life. In the present work, nanoparticles were prepared and evaluated. Optimization of formulation and ...
关键词：SIMVASTATIN Eudragit RS 100 NANOPARTICLES HYPERLIPIDEMIA 
Simvastatin/hydrogel-loaded 3D-printed titanium alloy scaffolds suppress osteosarcoma via TF/NOX2-associated ferroptosis while repairing bone defects被引量：2
《Bioactive Materials》2024年第4期463-465,共3页Zehao Jing Wanqiong Yuan Jiedong Wang Renhua Ni Yu Qin Zhinan Mao Feng Wei Chunli Song Yufeng Zheng Hong Cai Zhongjun Liu 
supported by National Natural Science Foundation of China(grant number 82272456 and 82202748);China Postdoctoral Science Foundation(grant number 2022M720297).
The authors regret to inform that the image in Fig.8 G was selected by mistake.The correct form of this figure is as below.The authors apologize for any inconvenience we caused and state that this correction does not ...
关键词：alloy titanium correction 
Simvastatin/hydrogel-loaded 3D-printed titanium alloy scaffolds suppress osteosarcoma via TF/NOX2-associated ferroptosis while repairing bone defects被引量：1
《Bioactive Materials》2024年第3期223-241,I0002-I0004,共19页Zehao Jing Wanqiong Yuan Jiedong Wang Renhua Ni Yu Qin Zhinan Mao Feng Wei Chunli Song Yufeng Zheng Hong Cai Zhongjun Liu 
supported by National Natural Science Foundation of China(grant number 82272456 and 82202748);China Postdoctoral Science Foundation(grant number 2022M720297).
Postoperative anatomical reconstruction and prevention of local recurrence after tumor resection are two vital clinical challenges in osteosarcoma treatment.A three-dimensional(3D)-printed porous Ti6Al4V scaffold(3DTi...
关键词：3D-printed titanium alloy IMPLANT SIMVASTATIN OSTEOSARCOMA Ferroptosis 
Enhanced osseointegration of drug eluting nanotubular dental implants: An in vitro and in vivo study
《Bioactive Materials》2023年第10期432-447,共16页Pankaj Chauhan Alok Srivastava Pooja Bhati Manish Chaturvedi Vinay Patil Sriram Kunnoth Nisha Kumari Vedpal Arya Madhur Pandya Mohit Agarwal Smiti Bhardwaj Farrukh Faraz Sanjay Chauhan Mahesh Verma Veena Koul Naresh Bhatnagar 
Faster and predictable osseointegration is crucial for the success of dental implants, especially in patients with compromised local or systemic conditions. Despite various surface modifications on the commercially av...
关键词：Titanium BIOCOMPATIBILITY SIMVASTATIN NANOTUBE Micro CT HISTOPATHOLOGY Nanoscale 
A rationally designed cancer vaccine based on NIR-II fluorescence image-guided light-triggered remote control of antigen cross-presentation and autophagy被引量：1
《Acta Pharmaceutica Sinica B》2023年第7期3121-3136,共16页Aihua Wu Afeng Yang Qinli Tong Guoguang Wei Sihang Zhang Sheng Yu Chen Zhang Jiaojiao Xu Wei Lu 
supported in part by grants from National Natural Science Foundation of China(No.81991493,China);Shanghai Municipal Health Commission(No.2022XD045,China)。
Cancer vaccines represent a promising immunotherapeutic treatment modality.The promotion of cross-presentation of extracellular tumor-associated antigens on the major histocompatibility complex(MHC) class I molecules ...
关键词：Vaccine Light-triggered NIR-II imaging CROSS-PRESENTATION AUTOPHAGY SIMVASTATIN Endolysosomal escape Dendritic cell maturation 
Simvastatin-hydroxyapatite coatings prevent biofilm formation and improve bone formation in implant-associated infections被引量：1
《Bioactive Materials》2023年第3期44-56,共13页Tiantong Sun Jie Huang Wang Zhang Xuanqi Zheng Hong Wang Jing Liu Huijie Leng Wanqiong Yuan Chunli Song 
National Key Research and Development Program[Grant No.2020YFC2009004];National Natural Science Foundation of China(Project No.81874010);PKU-Baidu Fund(Grant No.2020BD014).
Implant-associated infections(IAIs)caused by biofilm formation are the most devastating complications of orthopedic surgery.Statins have been commonly and safely used drugs for hypercholesterolemia for many years.Here...
关键词：Implant-associated infections SIMVASTATIN Antibacterial BIOFILM OSTEOGENESIS 
Construction and Properties of Simvastatin and Calcium Phosphate Dual-Loaded Coaxial Fibrous Membranes with Osteogenic and Angiogenic Functions
《Journal of Bionic Engineering》2022年第6期1645-1657,共13页Chang Liu Dan Deng Jing Gao Shue Jin Yi Zuo Yubao Li Jidong Li 
National Key Research and Development Program of China(2021YFA1201304/2021YFA1201300);National Natural Science Foundation of China(32171338).
The ideal Guided Bone Regeneration(GBR)membrane is required to have good biocompatibility,space maintenance ability,appropriate degradation rate,and preferably can guide the regeneration of vascularized bone tissue.In...
关键词：SIMVASTATIN Calcium PHOSPHATE COAXIAL ELECTROSPINNING VASCULARIZATION Guided Bone Regeneration 
Effects of Simvastatin on Endoplasmic Reticulum Stress-Mediated Apoptosis in Atherosclerotic Calcification
《Cardiology Discovery》2022年第4期209-217,共9页Jianhua Li Libo Zhao Zhe Zhou Lin Liu Xiao Zou Weihao Xu Li Fan Muyang Yan Shengqi Wang 
Objective:The effectiveness of statins in reducing atherosclerotic calcification remains controversial.The aim of this study was to confirm that simvastatin reduces atherosclerotic calcification and stabilizes plaque ...
关键词：Endoplasmic reticulum stress STATINS Atherosclerotic calcification APOPTOSIS 
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