Optimization of variables and assessment of in-vitro and in-vivo antihyperlipidemic activity of Eudragit RS nanoparticles containing simvastatin  

作　　者：Bina Gidwani Vishal Jain Veenu Joshi Ravindra Kumar Pandey Shiv Shankar Shukla Amber Vyas 

机构地区：[1]Columbia Institute of Pharmacy,Raipur(C.G.),India [2]University Institute of Pharmacy,Pt Ravishankar Shukla University,Raipur(C.G.),India [3]Center for Basic Science and Research,Pt Ravishankar Shukla University,Raipur(C.G.),India

出　　处：《Particuology》2024年第7期189-198,共10页颗粒学报（英文版）

基　　金：the Department of Science and Technology(DST-FIST)Letter no-SR/FST/COLLEGE/2018/418;New Delhi for providing financial assistance.The authors AV acknowledge the Department of Science and Technology,New Delhi,India(DST/INSPIRE Fellowship/2019/IF190329 and DST/NM/NT/2018/20)for providing financial assistance for the successful completion of this work.

摘　　要：Simvastatin, a BCS class II drug, is associated with poor aqueous solubility, first-pass metabolism and short half-life. In the present work, nanoparticles were prepared and evaluated. Optimization of formulation and process parameters was done through the use of independent and dependent variables. Preliminary studies were done to determine suitable range of the concentration of Eudragit polymer (10%–30%) and the ratio of drug to polymer (1:1 to 1:5) for the formation of nanoparticles by emulsification and a solvent evaporation technique. Results revealed that the mean size of nanoparticles was affected by stirring speed from 5000 RPM, 8000 RPM, and 12000 RPM. The results of increase in association efficiency and percent yield with increase in amount of drug from 100 mg, 150 mg, and 200 mg in selected range were observed. In-vitro release studies showed that two formulations possess highest initial burst and slow sustained drug release. There was 2.93-fold decrease in total cholesterol and 3.27-fold increases in triglyceride level during in-vivo study.

关 键 词：SIMVASTATIN Eudragit RS 100 NANOPARTICLES HYPERLIPIDEMIA 

分 类 号：TB383[一般工业技术—材料科学与工程]