STATIN

作品数：126被引量：295H指数：8
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Statins decrease the risk of hepatocellular carcinoma in metabolic dysfunction-associated steatotic liver disease:A systematic review and meta-analysis
《World Journal of Experimental Medicine》2024年第4期159-169,共11页Zahid Ijaz Tarar Umer Farooq Faisal Inayat Sanket D Basida Faisal Ibrahim Mustafa Gandhi Gul Nawaz Arslan Afzal Ammad J Chaudhary Faisal Kamal Ahmad H Ali Yezaz A Ghouri 
BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)is a leading cause of chronic liver disease with a significant risk of developing hepatocellular carcinoma(HCC).Recent clinical evidence indica...
关键词：Metabolic dysfunction-associated steatotic liver disease Hepatocellular carcinoma STATINS Lipophilic statin Hydrophilic statin META-ANALYSIS 
Simvastatin enhanced growth and altered testis transcriptome profiles of male tilapias
《Aquaculture and Fisheries》2024年第6期893-899,共7页Zituo Yang Fei Sun Le Wang Gen Hua Yue 
supported by the internal fund of the Temasek Life Sciences Laboratory,Singapore.
Simvastatin(SIM),a commonly prescribed drug for lowering serum-lipid,has been detected in many aquatic environments.Exposure to high concentrations of SIM in rats and aquatic organisms resulted in toxicity to hepatocy...
关键词：Fish STATIN GROWTH Reproduction AQUACULTURE 
Inhibiting HMGCR represses stemness and metastasis of hepatocellular carcinoma via Hedgehog signaling被引量：1
《Genes & Diseases》2024年第5期470-483,共14页Zhirong Zhang Jiayao Yang Rui Liu Jing Ma Kai Wang Xiaojun Wang Ni Tang 
the National Key Research and Development Program of China(No.2023YFC2306803);the China National Natural Science Foundation(No.82273238,82272975,82072286);the Innovative and Entrepreneurial Team of Chongqing Talents Plan,Chongqing Medical Scientific Research Project(Joint Project of Chongqing Health Commission and Science and Technology Bureau;No.2023DBXM007);Senior Medical Talents Program of Chongqing for Young and Middle-aged,the Kuanren Talents and DengFeng program of the Second Affiliated Hospital of Chongqing Medical University(China),the Future Medical Youth Innovation Team of Chongqing Medical University(China)(No.W0036,W0101);the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(No.GZC20233349).
Cancer stem cells(CSCs)play a crucial role in tumor initiation,recurrence,metastasis,and drug resistance.However,the current understanding of CSCs in hepatocellular carcinoma(HCC)remains incomplete.Through a comprehen...
关键词：Cancer stem cells HEDGEHOG Hepatocellular carcinoma METASTASIS STATIN 
Interpretation of Chinese Expert Consensus on the Diagnosis and Management Strategy of Patients with Statin Intolerance: A guiding file for helping to lipid management for Chinese population
《Journal of Geriatric Cardiology》2024年第7期713-715,共3页Jian-Jun LI 
supported by CAMS Innovation Fund for Medical Sciences(CIFMS,2021-I2M-C&TB-030).
It is well-known that elevated low-density lipoprotein cholesterol(LDL-C)is a causal risk factor for atheroscler-otic cardiovascular disease(ASCVD),statins are cornerstone drugs for the cause-based treatment of ASCVD,...
关键词：EXPERT STRATEGY CORNERS 
Statin, aspirin and metformin use and risk of hepatocellular carcinoma related outcomes following liver transplantation: A retrospective study
《World Journal of Transplantation》2024年第3期120-131,共12页William Chung Kevin Wong Noel Ravindranayagam Lauren Tang Josephine Grace Darren Wong Danny Con Marie Sinclair Avik Majumdar Numan Kutaiba Samuel Hui Paul Gow Vijayaragavan Muralidharan Alexander Dobrovic Adam Testro 
This study was approved by the Austin Health Human Ethics Research Committee(No.HREC/87459/Austin-2022).
BACKGROUND Liver transplantation(LT)is a potentially curative therapy for patients with hepatocellular carcinoma(HCC).HCC-recurrence following LT is associated with reduced survival.There is increasing interest in che...
关键词：Liver transplantation Hepatocellular carcinoma Transplant oncology STATINS HMG-Co-A reductase ASPIRIN METFORMIN Mammalian target of rapamycin 
The Great Cholesterol Quandary and Global Consciousness Awakening
《World Journal of Cardiovascular Diseases》2023年第11期718-755,共38页Abdullah Alabdulgader 
Ancestors of human species have been living on the planet earth for about six million years while the modern form of humans only evolved about 200,000 years ago. Civilization is only about 6000 years old, and industri...
关键词：ATHEROSCLEROSIS CHOLESTEROL STATIN Nobel Laureates Hypocholesterolemia Global Consciousness 
Rationale and design of a randomised double-blind 2×2 factorial trial comparing the effect of a 3-month intensive statin and antiplatelet therapy for patients with acute mild ischaemic stroke or high-risk TIA with intracranial or extracranial atherosclerosis(INSPIRES)被引量：3
《Stroke & Vascular Neurology》2023年第3期249-258,I0096-I0110,共25页Ying Gao Yuesong Pan Shangrong Han Weiqi Chen Jing Jing Chunjuan Wang Yingying Yang Tingting Wang Xia Meng Xingquan Zhao Liping Liu Hao Li S Claiborne Johnston Pierre Amarenco Philip M Bath Yongjun Wang Yilong Wang 
The study was supported by grants from the National Key R&D Program of China(No.2017YFC1307900,2017YFC1307905);The National Natural Science Foundation of China(No.81825007);Beijing Outstanding Young Scientist Program(No.BJJWZYJH01201910025030);Youth Beijing Scholar Program(No.010);Beijing Talent Project-Class A:Innovation and Development(No.2018A12);'National Ten-Thousand Talent Plan'-Leadership of Scientific and Technological Innovation,Sanofi,and Beijing Jialin Pharmaceutical Co.LTD.
Background It remains unclear if intensive antiplatelet and statin treatments begun within 24-72 hours of cerebral ischaemic events from intracranial or extracranial atherosclerosis is effective or safe.Methods The In...
关键词：INTRACRANIAL ATHEROSCLEROSIS random 
Use of two combination creams for the treatment of ichthyoses and ichthyosiform disorders
《Drug Combination Therapy》2023年第2期7-12,共6页Samar Khalil Serena Saade Divina Justina Hasbani Carla Stephan Tara Bardawil Adele Chedraoui Ossama Abbas Nelly Rubeiz Mazen Kurban 
Treatment options for ichthyosis and ichthyosiform disorders are limited and often unsatisfactory.Twenty-four patients used combination creams of 2%cholesterol with 2%lovastatin,and 10%glycolic acid with 0.025% tretin...
关键词：ICHTHYOSIS ichthyosiform disorders CHOLESTEROL STATIN TRETINOIN 
AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin被引量：1
《Acta Pharmacologica Sinica》2022年第11期2905-2916,共12页Nan Sheng Yun-qiu Wang Cun-fu Wang Meng-qi Jia Huan-min Niu Qi-qi Lu Ya-nan Wang Dan Feng Xiao-xue Zheng Hui-qing Yuan 
the National Natural Science Foundation of China(81872896,82173839 and 32000891);Natural Science Foundation of Shandong Province(ZR2020QH363).
Anterior gradient 2(AGR2),a protein disulfide isomerase(PDI),is a multifunctional protein under physiological and pathological conditions.In this study we investigated the roles of AGR2 in regulating cholesterol bioge...
关键词：HYPERCHOLESTEROLEMIA cholesterol biogenesis AGR2 AKT/SREBP2 statin resistance ALLICIN 
Efficacy of Aspirin and Statins in Treating Cerebral Thrombosis
《外文科技期刊数据库(文摘版)医药卫生》2022年第9期139-142,共4页YANGHongtao 
Objective: to analyze the clinical treatment effect of statin and aspirin drugs in patients with cerebral thrombosis. Methods: 60 patients with cerebral thrombosis admitted to our hospital from July 2020 to July 2021 ...
关键词：ASPIRIN STATIN cerebral thrombosis EFFICACY 
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