STATINS

作品数：168被引量：499H指数：9
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相关领域：医药卫生更多>>
相关作者：杨思进李洪林王捷频杨璞田俊更多>>
相关机构：华中科技大学泸州医学院第四军医大学北京协和医学院更多>>
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相关基金：国家自然科学基金北京市自然科学基金广东省自然科学基金江西省自然科学基金更多>>
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Anticonvulsant potential of rosuvastatin in combination with carbamazepine and valproate in animal models of epilepsy
《World Journal of Methodology》2025年第2期137-144,共8页Vandana Tayal Akash Mandal Ijasul Haque M Akhilesh Mishra Bhupinder S Kalra Vandana Roy 
BACKGROUND Epilepsy impacts millions of people,with many not responding to existing treatments.Some evidence links neuroinflammatory processes to epilepsy.Statins exhibit anti-inflammatory and neuroprotective properti...
关键词：ANTIEPILEPTIC ANTICONVULSANT STATINS ROSUVASTATIN Maximal electroshock seizure PENTYLENETETRAZOL 
Statins decrease the risk of hepatocellular carcinoma in metabolic dysfunction-associated steatotic liver disease:A systematic review and meta-analysis
《World Journal of Experimental Medicine》2024年第4期159-169,共11页Zahid Ijaz Tarar Umer Farooq Faisal Inayat Sanket D Basida Faisal Ibrahim Mustafa Gandhi Gul Nawaz Arslan Afzal Ammad J Chaudhary Faisal Kamal Ahmad H Ali Yezaz A Ghouri 
BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)is a leading cause of chronic liver disease with a significant risk of developing hepatocellular carcinoma(HCC).Recent clinical evidence indica...
关键词：Metabolic dysfunction-associated steatotic liver disease Hepatocellular carcinoma STATINS Lipophilic statin Hydrophilic statin META-ANALYSIS 
Mendelian randomization analysis:the causal relationship between statins and eye diseases
《Medical Data Mining》2024年第4期34-40,共7页Lian-Tai Song Jia-Meng Wei Hao-Ting Jia Feng-Yi Zhang Qing-Fang Deng Yi-Xiao Wang Huai-Zhi Qin Qian Xu 
the Education Department of Hebei Province(Project No.QN2016145)and the University Student Research Project of Chengde Medical University(2024038)for the funding support.
Background:The specific role of statins in the field of ophthalmology is not clear.Statins have the advantages of pleiotropic,relatively safety and low cost,and are a promising choice for the prevention and management...
关键词：Mendel randomization STATINS eye diseases 
Food-derived peptides with inhibitory capacity for HMG-CoA reductase activity: a potential nutraceutical for hypercholesterolemia
《Food Science and Human Wellness》2024年第6期3083-3094,共12页Guillermo Santos-Sánchez Ana IsabelÁlvarez-López Eduardo Ponce-España Patricia Judith Lardone Antonio Carrillo-Vico Ivan Cruz-Chamorro 
funded by Consejería de Salud, Junta de Andalucía (PC-0111-2016-0111);PEMP-0085-2020 (cofinanciado con fondos FEDER, convocatoria Resolución de 7 de julio de 2021 de la Secretaría General de Investigación, Desarrollo e Innovación en Salud, que convoca subvenciones para financiar la investigación, el desarrollo y la innovación en Biomedicina y Ciencias de la Salud en Andalucía, para 2021);the Programa PAIDI from the Junta de Andalucía (CTS160);supported by a FPU grant from the Spanish Ministerio de Educación, Cultura y Deporte (FPU16/02339);supported by the VI Program of Inner Initiative for Research and Transfer of the University of Seville (VIPPIT2020-II.4);by a postdoctoral fellowship from the Andalusian Government Ministry of Economy, Knowledge, Business, and University (DOC_00587/2020);funded by Andalusian Government Ministry of Health (PI-0136-2019);supported by the VI Program of Inner Initiative for Research and Transfer of University of Seville
Cardiovascular diseases(CVDs)are the leading global cause of mortality and disease burden.Statins are the most prescribed lipid-lowering drugs to treat hypercholesterolemia and prevent CVDs.The biochemical mechanism o...
关键词：Functional foods Cholesterol Cardiovascular diseases STATINS 3-Hydroxy-3-methylglutaryl-coenzyme A 
Atorvastatin ameliorated myocardial fibrosis by inhibiting oxidative stress and modulating macrophage polarization in diabetic cardiomyopathy
《World Journal of Diabetes》2024年第6期1070-1073,共4页Xiao-Tian Lei Dan-Lan Pu Geng Shan Qi-Nan Wu 
Supported by National Natural Science Foundation of China,No.82000792;General project of Chongqing Natural Science Foundation,No.cstc2020jcyj-msxm0409.
In this editorial,we commented on the article published in the recent issue of the World Journal of Diabetes.Diabetic cardiomyopathy(DCM)is characterized by myocardial fibrosis,ventricular hypertrophy and diastolic dy...
关键词：Diabetic cardiomyopathy STATINS MACROPHAGE Oxidative stress 
Construction and characterization of a humanized SLCO1B1 rat model with its application in evaluating the uptake of different statins
《Acta Pharmaceutica Sinica B》2024年第4期1592-1604,共13页Yuanjin Zhang Junze Huang Shengbo Huang Jie Liu Luyao Deng Chenmeizi Liang Yuanqing Guo Bingyi Yao Xin Wang 
This work was supported by grants from the National Natural Science Foundation of China(82274010);the Science and Technology Commission of Shanghai Municipality(18430760400,China);the East China Normal University(ECNU)Medicine and Health Joint Fund(2022JKXYD09004,China);the Jointed PI Program from Shanghai Changning Maternity and Infant Health Hospital;ECNU Construction Fund of Innovation and Entrepreneurship Laboratory.
Organic anion-transporting polypeptides IB1(OATPIB1)plays a crucial role in the transport of statins.However,there are too few animal models related to OATPIB1,especially humanized animal models.In this study,the huma...
关键词：CRISPR/Cas9 Drug transport Drug disposition Geneediting Humanized rat model OATP1B1 SLCO1B1 STATINS 
Influence of Statins and Fibrates Drugs on Bone Health and Regeneration
《Journal of Biomaterials and Nanobiotechnology》2024年第1期1-24,共24页Octavio Santiago Ivan Nadir Camal Ruggieri Marina Ribeiro Paulini Valéria Paula Sassoli Fazan João Paulo Mardegan Issa Sara Feldman 
In the medical and dental field, the importance and need for the study of materials and drugs for use as bone grafts or regeneration in injured areas due to the presence of fractures, infections or tumors that cause e...
关键词：Bone STATINS ROSUVASTATIN Sinvastatin FIBRATES FENOFIBRATE Bone Regeneration 
Statin, aspirin and metformin use and risk of hepatocellular carcinoma related outcomes following liver transplantation: A retrospective study
《World Journal of Transplantation》2024年第3期120-131,共12页William Chung Kevin Wong Noel Ravindranayagam Lauren Tang Josephine Grace Darren Wong Danny Con Marie Sinclair Avik Majumdar Numan Kutaiba Samuel Hui Paul Gow Vijayaragavan Muralidharan Alexander Dobrovic Adam Testro 
This study was approved by the Austin Health Human Ethics Research Committee(No.HREC/87459/Austin-2022).
BACKGROUND Liver transplantation(LT)is a potentially curative therapy for patients with hepatocellular carcinoma(HCC).HCC-recurrence following LT is associated with reduced survival.There is increasing interest in che...
关键词：Liver transplantation Hepatocellular carcinoma Transplant oncology STATINS HMG-Co-A reductase ASPIRIN METFORMIN Mammalian target of rapamycin 
High density lipoprotein as a therapeutic target:Focus on its functionality
《BIOCELL》2023年第11期2361-2383,共23页LEONARDO GÓMEZ ROSSO BELÉN DAVICO EZEQUIEL LOZANO CHIAPPE WALTER TETZLAFF LAURA BOERO FERNANDO BRITES MAXIMILIANO MARTÍN 
Cardiovascular diseases(CVDs)are the leading cause of death globally.CVDs are a group of disorders of the heart and blood vessels and include coronary heart disease,cerebrovascular disease and rheumatic heart disease ...
关键词：HDL Cholesterol efflux rHDL Apo A-I mimetics STATINS PARAOXONASE 
Statins markedly potentiate aminopeptidase inhibitor activity against(drug-resistant)human acute myeloid leukemia cells
《Cancer Drug Resistance》2023年第3期430-446,共17页Gerrit Jansen Marjon Al Yehuda G.Assaraf Sarah Kammerer Johan van Meerloo Gert J.Ossenkoppele Jacqueline Cloos Godefridus J.Peters 
This study was supported by Cancer Center Amsterdam grants 07/36 and 2012-1-08.
Aim: This study aimed to decipher the molecular mechanism underlying the synergistic effect of inhibitors of the mevalonate-cholesterol pathway (i.e., statins) and aminopeptidase inhibitors (APis) on APi-sensitive and...
关键词：AMINOPEPTIDASE STATINS mevalonate pathway carboxyl esterase RHEB mTOR 
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