PENTYLENETETRAZOL

作品数：19被引量：23H指数：2
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相关作者：王伟何小华阮旭中李文鑫张梁更多>>
相关机构：中国科学院上海生命科学研究院同济医科大学附属同济医院武汉大学上海大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《Acta Biochimica et Biophysica Sinica》《Asian Pacific Journal of Tropical Biomedicine》《Journal of Traditional Chinese Medicine》更多>>
相关基金：国家自然科学基金更多>>
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Anticonvulsant potential of rosuvastatin in combination with carbamazepine and valproate in animal models of epilepsy
《World Journal of Methodology》2025年第2期137-144,共8页Vandana Tayal Akash Mandal Ijasul Haque M Akhilesh Mishra Bhupinder S Kalra Vandana Roy 
BACKGROUND Epilepsy impacts millions of people,with many not responding to existing treatments.Some evidence links neuroinflammatory processes to epilepsy.Statins exhibit anti-inflammatory and neuroprotective properti...
关键词：ANTIEPILEPTIC ANTICONVULSANT STATINS ROSUVASTATIN Maximal electroshock seizure PENTYLENETETRAZOL 
Rauvolfa vomitoria phenol extract relieves pentylenetetrazol-induced seizures in Swiss mice and protects some temporal lobe structures
《Acta Epileptologica》2024年第4期303-317,共15页Moses B.Ekong Okokon O.Bassey Deborah I.Ebeh Godslove D.Usukuma Darlington C.Samuel Rosemary B.Bassey Aniekan I.Peter Christopher C.Mbadugha Jude E.Okokon Monday I.Akpanabiatu 
supported in part by the Tertiary Education Trust Fund(TETFund).The International Brain Research Organization(IBRO)Early Career Grant and the International Society for Neurochemistry(ISN)Committee for Aid and Education in Neurochemistry(CAEN)provided the funding for small equipment.
Background Rauvolfa vomitoria(R.vomitoria)is a plant of economic importance due to its diverse ethnomedicinal properties,including the anticonvulsant efect.In this study,we studied the antiseizure and neuroprotective ...
关键词：SEIZURE Cognitive behaviour Neurochemicals Temporal lobe Sodium valproate Swiss mice 
Sphingosine 1-phosphate receptor 1 regulates bloodbrain barrier permeability in epileptic mice被引量：3
《Neural Regeneration Research》2023年第8期1763-1769,共7页Li-Xiang Yang Yuan-Yuan Yao Jiu-Rong Yang Hui-Lin Cheng Xin-Jian Zhu Zhi-Jun Zhang 
supported by the National Natural Science Foundation of China,Nos.82071393(to HLC),81830040(to ZJZ),82130042(to ZJZ);Science and Technology Program of Guangdong Province,No.2018B030334001(to ZJZ);the Program of Excellent Talents in Medical Science of Jiangsu Province,No.JCRCA2016006(to ZJZ)。
Destruction of the blood-brain barrier is a critical component of epilepsy pathology.Several studies have demonstrated that sphingosine 1-phosphate receptor 1 contributes to the modulation of vascular integrity.Howeve...
关键词：adeno-associated virus ASTROCYTES blood-brain barrier EPILEPSY epilepsy-associated depression-like behavior NEUROINFLAMMATION PENTYLENETETRAZOL PILOCARPINE tight junction 
Efficacy and mechanisms of Dingxian pill(定痫丸)combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats被引量：1
《Journal of Traditional Chinese Medicine》2023年第2期286-294,共9页QU Dongxiao GE Yiqin ZHUO Limin CHEN Liji XUE Yonghua CHENG Jiwei TAO Jie LI Guoyi ZHU Yudan XIAO Qian 
Supported by National Natural Science Foundation of China:Molecular Mechanism Underlying the Intervention of Scorpion Extract BmK IT2 on Epileptogenesis via Voltage-gated Nav1.6 Channels in Hippocampal Neurons(No.81903995);Molecular Mechanism Underlying the Intervention of Scorpion Polypeptide MarTX on Temporal Lobe Epileptogenesis by Inhibiting Mechanosensitive Channel Piezo1(No.82074162);Youth Talent Promotion Project of China Association of Chinese Medicine(No.CACM-2019-QNRC2-C10);Project for Capacity Promotion of Putuo District Clinical Special Disease(Stroke,2019tszb02);Science and Technology Innovation Project of Putuo District Health System:Molecular Mechanism of Aerobic Exercise Intervention on Post-epileptic Depression Through"Bone-brain Axis"(No.ptkwws202107);the Antiepileptic Mechanism of Scorpion Active Extract BmK AS Regulating Nav1.6 Sodium Channel in Hippocampal Pyramidal Neurons(No.ptkwws201902);Evaluation of Microglial Lysosomal BK Channels as Molecular Targets for Clinical Treatment of Temporal Lobe Epilepsy(ptkwws201908);Molecular Mechanism of Sodium Channel SCN8A(Nav1.6)Mutation Mediating Epilepsy and Sodium Valproate Resistance in Children the Research Project of Putuo Hospital,Shanghai University of Traditional Chinese Medicine(No.2019308),(No.2019307)。
OBJECIVE:To investigate the efficacy and mechanisms of Dingxian pill(定痫丸)combined with valproic acid(VPA)on pentylenetetrazol-induced chronical epilepsy in rats.METHODS:A rat model of epilepsy was established by ad...
关键词：EPILEPSY Valproic Acid learning memory TRANSCRIPTOME Dingxian pill 
The role of miRNA21 in hippocampal neurons of rats with pentylenetetrazol-induced epilepsy and its mechanism
《Journal of Hainan Medical University》2019年第10期23-27,共5页Dong-Hai Liu Tian-Ning Zhao Jia-Qi Yang Xue-Tong Tao Jing-Bo Zhang Yu-Ran Chen Lu-Lu Yang Xue Liu Hai-Peng Song Jin-Ling Zhu 
Objective: To investigate the expression of miRNA21 in hippocampus of rats with pentylenetetrazol-induced epilepsy and its possible mechanism. Methods: Twenty-four healthy male wister rats was randomly divided into tw...
关键词：EPILEPSY miRNA21 Bcl-2 APOPTOSIS HIPPOCAMPAL NEURON 
Anti-epileptic effect of morin against experimental pentylenetetrazol-induced seizures via modulating brain monoamines and oxidative stress
《Asian Pacific Journal of Tropical Biomedicine》2018年第7期352-359,共8页Amit D.Kandhare Anwesha A.Mukherjee Subhash L.Bodhankar 
Objective: To evaluate the protective effect of morin against pentylenetetrazol(PTZ)-induced tonic-clonic convulsions in mice. Methods: Swiss albino mice(18-22 g) was used to induce convulsions by intraperitoneal(i.p....
关键词：Brain GABA Epilepsy MORIN Nitric oxide PENTYLENETETRAZOL Oxidative stress Xanthine oxidase 
The Effects of the Enriched Environment on Sympathetic Skin Response in Pentylenetetrazol-Kindled Rats被引量：2
《Biomedical and Environmental Sciences》2013年第5期394-397,共4页Nazan DOLU Seval KELOGLAN Soner BITIKTAS Setenay CUG 
supported by the Research Fund of the Erciyes University(TSD-09-1039)
Epilepsy is a neurodegenerative disease that interrupts the normal electrical activity of the brain and promotes abnormal wiring in this organ.Epileptic seizures are often associated with significant changes in the fu...
关键词：The Effects of the Enriched Environment on Sympathetic Skin Response in Pentylenetetrazol-Kindled Rats CAGE 
Antiepileptic activity of lobeline isolated from the leaf of Lobelia nicotianaefolia and its effect on brain GABA level in mice
《Asian Pacific Journal of Tropical Biomedicine》2012年第7期537-542,共6页Abrar M Tamboli Rukhsana A Rub Pinaki Ghosh SL Bodhankar 
Supported by University of Pune(Grant No.BCUD/OSD/390)
Objective:To investigate the anticonvulsant activity of the lobeline isolated from the Lobelia nicotianaefolia in chemoconvulsant-induced seizures and its biochemical mechanism by investigating relationship between se...
关键词：LOBELIA nicotianaefolia Lobeline BRAIN GABA level ANTIEPILEPTIC activity Pentylenetetrazol(PTZ) STRYCHNINE 
Neuronal conditional knockout of NRSF decreases vulnerability to seizures induced by pentylenetetrazol in mice被引量：2
《Acta Biochimica et Biophysica Sinica》2012年第6期476-482,共7页Ming Liu Zhejin Sheng Lei Cai Kai Zhao Yu Tian Jian Fei 
Neuron restrictive silencer factor （NRSF）, also known as repressor element-I silencing transcription factor, has been reported to modulate neuronal excitability and acts as endogenous anticonvulsant in kainic acid-i...
关键词：neuron restrictive silencer factor conditionalknockout PENTYLENETETRAZOL SEIZURE 
Hippocampal and cortical expression of gamma-aminobutyric acid transporter 1 and glial fibrillary acidic protein in pentylenetetrazol-induced chronic epileptic rats被引量：2
《Neural Regeneration Research》2009年第3期194-199,共6页Yi Zeng Zhong Yang Xiaodong Long Chao You 
Supported by:the Science and Technology Development Program of Sichuan Provincial Science and Technology Department, No 05SG022-013
BACKGROUND： Gamma-aminobutyric acid transporter plays an important role in gamma-aminobutyric acid metabolism, and is highly associated with epilepsy seizures. Pathologically, astrocytes release active substances tha...
关键词：EPILEPSY glial fibrillary acidic protein gamma-aminobutyric acid transporter 1 oentvlenetetrazol astrocvte 
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