Anticonvulsant potential of rosuvastatin in combination with carbamazepine and valproate in animal models of epilepsy  

作　　者：Vandana Tayal Akash Mandal Ijasul Haque M Akhilesh Mishra Bhupinder S Kalra Vandana Roy 

机构地区：[1]Department of Pharmacology,Maulana Azad Medical College,New Delhi 110002,India [2]Department of Pharmacology,MES Medical College,Perintalmanna 679338,Kerala,India [3]Department of Central Animal Facility,Maulana Azad Medical College,New Delhi 110002,India

出　　处：《World Journal of Methodology》2025年第2期137-144,共8页世界方法学杂志（英文）

摘　　要：BACKGROUND Epilepsy impacts millions of people,with many not responding to existing treatments.Some evidence links neuroinflammatory processes to epilepsy.Statins exhibit anti-inflammatory and neuroprotective properties,potentially offering antiepileptic effects.AIM To evaluate the anticonvulsant effects of rosuvastatin in animal models of epilepsy.METHODS Ninety-six albino mice were divided into 16 groups.In the maximal electroshock seizure(MES)model,eight groups received intraperitoneal vehicle,carbama-zepine,rosuvastatin,or a combination.Outcomes measured included seizure protection[tonic hind limb extension(THLE)],duration of THLE,seizure duration,and mortality.In the pentylenetetrazol(PTZ)model,eight groups were pretreated with vehicle,valproate,rosuvastatin,or a combination,with outcomes measured as seizure latency,seizure duration,and mortality.RESULTS In the MES model,rosuvastatin exhibited protection against THLE in a small percentage of mice.Rosuvastatin shortens the duration of THLE in a dose-dependent manner.However,none of these were statistically significant com-pared to the control group.The combination of rosuvastatin 10 mg/kg with carbamazepine 4 mg/kg resulted in a significant reduction in seizure duration compared to the control group,better than carbamazepine alone at 4 mg/kg and 6 mg/kg.In the PTZ model,rosuvastatin alone showed no significant effects on latency,duration of seizure,or mortality.However,rosuvastatin 10 mg/kg combined with valproate 100 mg/kg significantly delayed the onset of seizures,seizure duration and mortality percentage,better than valproate alone at 100 mg/kg.CONCLUSION Rosuvastatin enhanced the anticonvulsant effects of carbamazepine and valproate.Further studies are required to explore the antiepileptic potential of rosuvastatin at various doses,durations,dosage forms,routes and models.

关 键 词：ANTIEPILEPTIC ANTICONVULSANT STATINS ROSUVASTATIN Maximal electroshock seizure PENTYLENETETRAZOL 

分 类 号：R-332[医药卫生]