ANTIEPILEPTIC

作品数：36被引量：64H指数：4
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相关领域：医药卫生更多>>
相关作者：古艳婷陆钦池张艳欣李颖廖玉芳更多>>
相关机构：山西医科大学上海交通大学医学院附属仁济医院复旦大学更多>>
相关期刊：《Chinese Medical Sciences Journal》《Asian Pacific Journal of Tropical Biomedicine》《Plant Diseases and Pests》《Journal of Traditional Chinese Medicine》更多>>
相关基金：国家自然科学基金广东省自然科学基金更多>>
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Anticonvulsant potential of rosuvastatin in combination with carbamazepine and valproate in animal models of epilepsy
《World Journal of Methodology》2025年第2期137-144,共8页Vandana Tayal Akash Mandal Ijasul Haque M Akhilesh Mishra Bhupinder S Kalra Vandana Roy 
BACKGROUND Epilepsy impacts millions of people,with many not responding to existing treatments.Some evidence links neuroinflammatory processes to epilepsy.Statins exhibit anti-inflammatory and neuroprotective properti...
关键词：ANTIEPILEPTIC ANTICONVULSANT STATINS ROSUVASTATIN Maximal electroshock seizure PENTYLENETETRAZOL 
“Three-in-one” strategy of trifluoromethyl regulated blood-brain barrier permeable fluorescent probe for peroxynitrite and antiepileptic evaluation of edaravone
《Chinese Chemical Letters》2024年第10期360-363,共4页Lei Shen Hongmei Liu Ming Jin Jinchao Zhang Caixia Yin Shuxiang Wang Yutao Yang 
supported by the National Natural Science Foundation of China(Nos.22177025,21807021,22325703,22177026);Science Fund for Creative Research Groups of Nature Science Foundation of Hebei Province(No.B2021201038);the Interdisciplinary Research Program of Natural Science of Hebei University(No.DXK202113);the Central Government Guided Local Science,Technology Development Fund(Hebei Province,No.216Z2603G);National High-End Foreign Expert Recruitment Plan(No.G2022003007L)。
Epilepsy,as a chronic neurological disease of the brain,is closely related to oxidative stress,and the peroxynitrite(ONOO-)significantly rise up in this event.Therefore,ONOO-is considered as a potential biomarker for ...
关键词：Fluorescent probe Blood-brain barrier PEROXYNITRITE EPILEPSY Drug repurposing 
Pharmacologic Effects of Cannabidiol and Its Molecular Mechanism
《Plant Diseases and Pests》2024年第4期43-46,共4页Jundong GUAN Anqi WANG Jiazhu LI Jingjing WEN Changtao CAI Chenghao JIN 
Supported by Central Government Supports Local College Reform and Development Fund Talent Training Projects(2020GSP16);Heilongjiang Provincial Key Research and Development Plan Guidance Project(GZ20220039).
Cannabidiol(CBD)is the active constituent of Cannabis sativa and exhibits a diverse range of pharmacologic effects,including anticancer,antibacterial,anti-inflammatory,antioxidant,and antiepileptic properties.The phar...
关键词：CANNABIDIOL ANTICANCER ANTIBACTERIAL ANTI-INFLAMMATORY Antioxidant ANTIEPILEPTIC 
Postoperativeinte rictalepil eptiform discharges predict seizure recurrence after antiepileptic drug withdrawal regardless of concordance with surgical site
《World Journal of Pediatric Surgery》2024年第1期33-41,共9页Yuxin Wu ZaiYu Zhang Ping Liang Lusheng Li Bin Zou Difei Wang Xinyu Dong Haotian Tang Hanli Qiu Xuan Zhai 
Supported by the National Natural Science Foundation of China(grant no:81971217).
Objective The study aimed to explore the association between the site of interictal epileptic discharges(IEDs)on postoperative electroencephalogram(EEG)and seizure recurrence after antiepileptic drug(AED)withdrawal.Th...
关键词：SURGICAL SEIZURE epileptic 
Low-dose clozapine-related seizure: A case report and literature review被引量：1
《World Journal of Clinical Cases》2021年第20期5611-5620,共10页Dan-Sheng Le Heng Su Zheng-Luan Liao En-Yan Yu 
BACKGROUND Treatment-resistant schizophrenia is a severe form of schizophrenia characterized by poor response to at least two antipsychotic drugs and is typically treated with clozapine.However,clozapine lowers the ep...
关键词：SEIZURE Treatment-resistant schizophrenia ANTIPSYCHOTIC ANTIEPILEPTIC Electroconvulsive therapy Case report 
Intranasal ginsenoside Rb1 protects pentyl⁃enetetrazole-induced epileptic mice
《中国药理学与毒理学杂志》2021年第9期673-673,共1页LI Juan LIU Yu-shu WANG Xi LIU Ying MA Qing TANG Min-ke 
OBJECTIVE To evaluate whether ginsenoside Rb1 has antiepileptic effects on pen⁃tylenetetrazole(PTZ)-induced epileptic mice via intranasal therapeutic administration.METHODS Rb1 monoclonal antibody was used to observe ...
关键词：ginsenoside Rb1 antiepileptic effects epileptic mice PENTYLENETETRAZOLE wireless electroencephalogram 
Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels被引量：3
《Acta Pharmacologica Sinica》2020年第5期629-637,共9页Zhu-qing Xie Xiao-ting Tian Yue-ming Zheng Li Zhan Xue-qin Chen Xiao-ming Xin Cheng-gang Huang Zhao-bing Gao 
the National Science Fund for Distinguished Young Scholars(81825021);the Personalized Medicines“Molecular Signature-Based Drug Discovery and Development”(Strategic Priority Research Program of the Chinese Academy of Sciences,Grant Nos.XDA12040221 and XDA15050308);the National Natural Science Foundation of China(81603096,81773707,and 61433017);Shanghai Municipal Science and Technology Major Project(2018SHZDZX01)and ZJ Lab.
Geissoschizine methyl ether(GM)is an indole alkaloid isolated from Uncaria rhynchophyll(UR)that has been used for the treatment of epilepsy in traditional Chinese medicine.An early study in a glutamate-induced mouse s...
关键词：geissoschizine methyl ether Uncaria rhynchophyll antiepileptic drug hippocampal neurons action potential nicotinic acetylcholine receptors voltage-gated ion channels mouse seizure model 
Extended Antiepileptic Drug Prophylaxis and Late Onset Seizures in Aneurysmal Subarachnoid Hemorrhage
《Open Journal of Modern Neurosurgery》2019年第4期401-409,共9页Wen Hao Low Qing Yuan Goh Miqi Mavis Teo 
Background: The indication and optimal duration of antiepileptic drug (AED) prophylaxis after aneurysmal subarachnoid hemorrhage (SAH) remains controversial. Our institution practices routine seizure prophylaxis for v...
关键词：ANTIEPILEPTIC SEIZURE PROPHYLAXIS Aneursymal SUBARACHNOID HEMORRHAGE 
Low-velocity simultaneous bilateral femoral neck fracture following long-term antiepileptic therapy:A case report被引量：5
《World Journal of Orthopedics》2019年第10期371-377,共7页Mohammed Sadiq Vikrant Kulkarni Syed Azher Hussain Mohammed Ismail Mayur Nayak 
BACKGROUND Simultaneous bilateral femoral neck fractures are relatively rare injuries.They are usually associated with underlying metabolic bone disorders or systemic diseases.Long-term use of narcotics and bisphospho...
关键词：Case report BILATERAL FEMORAL neck fracture ANTIEPILEPTIC drug THERAPY Druginduced OSTEOPENIA BISPHOSPHONATES Vitamin D 
A pharmacodynamic model of respiratory rate and end-tidal carbon dioxide values during anesthesia in children被引量：1
《Acta Pharmacologica Sinica》2019年第5期642-647,共6页Ji-Hyun Lee Pyo-Yoon Kang Young-Eun Jang Eun-Hee Kim Jin-Tae Kim Hee-Soo Kim 
It is essential to monitor the end-tidal carbon dioxide (ETCO2) during general anesthesia and adjust the tidal volume and respiratory rate (RR). For the purpose of this study, we used a population pharmacodynamic mode...
关键词：PEDIATRIC ANESTHESIA end-tidal carbon dioxide RESPIRATORY rate population PHARMACODYNAMIC modeling ANTIEPILEPTIC drugs 
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