Low-dose clozapine-related seizure: A case report and literature review  

作　　者：Dan-Sheng Le Heng Su Zheng-Luan Liao En-Yan Yu 

机构地区：[1]The Second Clinical Medical College,Zhejiang Chinese Medicine University,Hangzhou 310051,Zhejiang Province,China [2]Department of Psychiatry,Zhejiang Provincial People’s Hospital,Hangzhou 310000,Zhejiang Province,China [3]Department of Psychiatry,The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital),Institute of Basic Medicine and Cancer,Chinese Academy of Sciences,Hangzhou 310022,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2021年第20期5611-5620,共10页世界临床病例杂志

摘　　要：BACKGROUND Treatment-resistant schizophrenia is a severe form of schizophrenia characterized by poor response to at least two antipsychotic drugs and is typically treated with clozapine.However,clozapine lowers the epileptic threshold,leading to seizures,which are severe side effects of antipsychotics that result in multiple complications.Clozapine-related seizures are generally considered to be dose-dependent and especially rare in the low-dose(150-300 mg/d)clozapine treated population.Due to clinical rarity,little is known about its clinical characteristics and treatment.CASE SUMMARY A 62-year-old Chinese man with a 40-year history of treatment-resistant schizophrenia presented to the Emergency Department with symptoms of myoclonus,consciousness disturbance and vomiting after taking 125 mg clozapine.Upon admission,the patient had a suddenly generalized tonic-clonic seizure lasting for about half a minute with persistent disturbance of consciousness,fever,cough and bloody sputum,which was considered to be low-dose clozapine-related seizure.After antiepileptic and multiple anti-infection treatments,the patient was discharged without epileptic or psychotic symptoms.CONCLUSION Our aim is to highlight the early prevention and optimal treatment of clozapine related seizure through case analysis and literature review.

关 键 词：SEIZURE Treatment-resistant schizophrenia ANTIPSYCHOTIC ANTIEPILEPTIC Electroconvulsive therapy Case report 

分 类 号：R742.1[医药卫生—神经病学与精神病学]