ANTIPSYCHOTIC

作品数：49被引量：99H指数：4
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相关领域：医药卫生更多>>
相关作者：张志君高瑞更多>>
相关机构：南京医科大学附属脑科医院首都医科大学更多>>
相关期刊：《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《Psychology Research》《Pharmacology & Pharmacy》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Carbazole and tetrahydro-carboline derivatives as dopamine D_(3) receptor antagonists with the multiple antipsychotic-like properties被引量：1
《Acta Pharmaceutica Sinica B》2023年第11期4553-4577,共25页Zhongtang Li Fan Fang Yiyan Li Xuehui Lv Ruqiu Zheng Peili Jiao Yuxi Wang Guiwang Zhu Zefang Jin Xiangqing Xu Yinli Qiu Guisen Zhang Zhongjun Li Zhenming Liu Liangren Zhang 
supported by The National Key R&D Program (2022YFC2303700,China);the Ningxia Hui Autonomous Region Key Research and Development Project (2022BEG02042,China);the National Natural Science Foundation of China (82030108,81803351);Open Fund of State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University (KF-202304,China);the China Postdoctoral Science Foundation (2018M641122,China);the National Major Scientific and Technological Special Project for Significant New Drugs Development (2018ZX09711002-013-004,2018ZX09735-001,China)。
Dopamine D_(3) receptor(D_(3)R)is implicated in multiple psychotic symptoms.Increasing the D_(3)R selectivity over dopamine D_2 receptor(D_2R)would facilitate the antipsychotic treatments.Herein,novel carbazole and te...
关键词：Dopamine D_(3)receptor Carbazole derivatives Tetrahydro-carboline Bitopic ligand ANTIPSYCHOTIC 
Tardive sensory syndrome related to lurasidone:A case report被引量：1
《World Journal of Psychiatry》2023年第3期126-130,共5页Mei-Chun Lin Yung-Yee Chang Yu Lee Liang-Jen Wang 
BACKGROUND Tardive sensory syndrome(TSS)is a subtype of tardive syndrome(TS),and its etiology is still uncertain.Lurasidone is an atypical antipsychotic that has high affinity for dopamine D2-and serotonergic 5HT2A-an...
关键词：ANTIPSYCHOTIC Tardive syndrome Tardive sensory syndrome LURASIDONE Case report 
Inhibitory Effect of 5-Adenylic Acid on Bitter Taste of Antipsychotic Drugs
《Pharmacology & Pharmacy》2022年第10期429-446,共18页Jun Kawahara Rio Uno Honami Kojima Miyako Yoshida Takahiro Uchida Hidekazu Ikezaki Masaaki Habara 
The purpose of the present study was to examine the effect of adenylic acid (adenosine 5-monophosphate;AMP), a known nutritional enhancer, on inhibiting the bitterness of antipsychotic medicines administered to patien...
关键词：Adenylic Acid BITTERNESS Antipsychotic Medicine AMITRIPTYLINE CHLORPROMAZINE HALOPERIDOL RISPERIDONE Taste Sensor Drug-Drug Interaction 
A case of antipsychotic-induced psychomotor seizure
《General Psychiatry》2022年第3期209-213,共5页Yanqun Zheng Xiaohua Liu Mingliang Ju 
supported by projects from National Natural Science Foundation of China(81971273,81000588).Project of Shanghai Municipal Health Commission(GWV-10.2-XD28).
A seizure is one of the most uncommon severe adverse side effects of antipsychotics.Clinical recognition rates for it are low,especially for psychomotor seizures.The authors present a case of psychomotor seizure cause...
关键词：SEIZURE seizures CLINICAL 
Antipsychotics preserve telomere length in peripheral blood mononuclear cells after acute oxidative stress injury
《Neural Regeneration Research》2022年第5期1156-1160,共5页Gabriel B.Polho Giancarlo M.Cardillo Daniel S.Kerr Thais Chile Wagner F.Gattaz Orestes V.Forlenza Helena P.Brentani Vanessa J.De-Paula 
supported by grants from FAPESP(Fundacao de AmparoàPesquisa de Sao Paulo,Grant no 2016/01302-9 and 2014/27129-6);CAPES(Coordenacao de Aperfeicoamento de Pessoal de Nível Superior)88887.463672/2019-00。
Antipsychotics may prolong or retain telomere length,affect mitochondrial function,and then affect the metabolism of nerve cells.To validate the hypothesis that antipsychotics can prolong telomere length after oxidati...
关键词：ANTIPSYCHOTIC ARIPIPRAZOLE cell culture CLOZAPINE HALOPERIDOL oxidative stress peripheral blood mononuclear cell telomere length 
Trajectories of response in schizophrenia-spectrum disorders: A one-year prospective cohort study of antipsychotic effectiveness被引量：2
《World Journal of Psychiatry》2022年第3期521-532,共12页Petros Drosos Erik Johnsen Christoffer Andreas Bartz-Johannessen Tor Ketil Larsen Solveig Klæbo Reitan Maria Rettenbacher Rune Andreas Kroken 
Supported by Drosos P is a Research Fellow with a Grant From the Western Norway Regional Health Trust,No. 912140
BACKGROUND Antipsychotic drugs remain the mainstay of schizophrenia treatment;however,their effectiveness has been questioned,and it is not possible to predict the response to a specific antipsychotic drug in an indiv...
关键词：SCHIZOPHRENIA RESPONSE Trajectories Treatment Antipsychotic drugs 
Therapeutic use of melatonin in schizophrenia-more than meets the eye!被引量：1
《World Journal of Psychiatry》2022年第3期533-535,共3页Ahmed Naguy 
Adjunctive melatonin use in schizophrenia, as supported by a modicum ofevidence, has multiple transcending chronobiotic actions, including fixingconcurrent sleep problems to bona fide augmentative antipsychotic action...
关键词：MELATONIN SCHIZOPHRENIA Chronobiotic NEUROPROTECTANT ANTIPSYCHOTIC Tardive dyskinesia Metabolic syndrome 
Distinct neuroanatomic subtypes in antipsychotic-treated patients with schizophrenia classified by the predefined classification in a never-treated sample
《Psychoradiology》2021年第4期212-224,共13页Qiannan Zhao Jiao Li Yuan Xiao Hengyi Cao Xiao Wang Wenjing Zhang Siyi Li Wei Liao Qiyong Gong Su Lui 
supported by the National Natural Science Foundation of China[Grant Nos.82120108014(to S.L.),82071908(to S.L.),81671664(to S.L.),81621003(to Q.G.),81820108018(to Q.G.),and 81901705(to Y.X.)];the US-China joint grant[Grant Nos NSFC81761128023(to Q.G.),R01MH112189-01(to Q.G.)];1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University[Project Nos.ZYYC08001(to S.L.)and ZYJC18020(to S.L.)];Sichuan Science and Technology Program[Grant Nos.2021JDTD0002(to S.L.)and 2020YFS0116(to Y.X.)];China Postdoctoral Science Foundation[Grant No.2019M663513(to Y.X.)];the Postdoctoral Interdisciplinary Research Project of Sichuan University[Grant No.0040204153082(to Y.X.)];S.L.acknowledges support from Humboldt Foundation Research Awards and Chang Jiang Scholars(Program No.T2019069).
Background:Distinct neuroanatomic subtypes have been identified in never-treated patients with schizophrenia based on cerebral structural abnormalities,but whether antipsychotic-treated patients would be stratified un...
关键词：SCHIZOPHRENIA neuroanatomic heterogeneity psychoradiology cognitive function antipsychotic medication 
Low-dose clozapine-related seizure: A case report and literature review被引量：1
《World Journal of Clinical Cases》2021年第20期5611-5620,共10页Dan-Sheng Le Heng Su Zheng-Luan Liao En-Yan Yu 
BACKGROUND Treatment-resistant schizophrenia is a severe form of schizophrenia characterized by poor response to at least two antipsychotic drugs and is typically treated with clozapine.However,clozapine lowers the ep...
关键词：SEIZURE Treatment-resistant schizophrenia ANTIPSYCHOTIC ANTIEPILEPTIC Electroconvulsive therapy Case report 
Metabolic disturbances associated with antipsychotic drug treatment in patients with schizophrenia:State-of-the-art and future perspectives被引量：3
《World Journal of Psychiatry》2021年第10期696-710,共15页Shen-Chieh Chang Kah Kheng Goh Mong-Liang Lu 
Supported by the Higher Education Sprout Project of the Ministry of Education,No.DP2-109-21121-01-N-07-04;the Ministry of Science and Technology,No.MOST109-2314-B-038-083.
Metabolic disturbances and obesity are major cardiovascular risk factors in patients with schizophrenia,resulting in a higher mortality rate and shorter life expectancy compared with those in the general population.Al...
关键词：ANTIPSYCHOTICS Metabolic disturbances Weight gain SCHIZOPHRENIA MONITOR INTERVENTION 
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