Tardive sensory syndrome related to lurasidone:A case report  

作　　者：Mei-Chun Lin Yung-Yee Chang Yu Lee Liang-Jen Wang 

机构地区：[1]Department of Psychiatry,Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung,Kaohsiung 83301,Taiwan,china [2]Department of Neurology,Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung,Kaohsiung 83301,Taiwan,china [3]Department of Child and Adolescent Psychiatry,Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine,Kaohsiung 83301,Taiwan,china

出　　处：《World Journal of Psychiatry》2023年第3期126-130,共5页世界精神病学杂志

摘　　要：BACKGROUND Tardive sensory syndrome(TSS)is a subtype of tardive syndrome(TS),and its etiology is still uncertain.Lurasidone is an atypical antipsychotic that has high affinity for dopamine D2-and serotonergic 5HT2A-and 5-HT7-receptors.CASE SUMMARY A 52-year-old woman,previously diagnosed with schizophrenia,and with no history of movement disorders and no sensory paresthesia,had taken lurasidone,initiate dose 40 mg daily then up titration to 120 mg daily,since March 2021,and developed mandibular sensory(pain)paresthesia after 3 mo of administration.After switching from lurasidone to quetiapine,she reported obvious improvement in her mandibular pain.CONCLUSION It is noteworthy that TSS is a rare subtype of TS,and lurasidone,an atypical antipsychotic,usually has a lower risk of causing TS.In light of the temporal relationship,it is therefore concluded that use of lurasidone might have caused TSS in this patient.We reported this rare case as a reminder that clinicians should adopt a cautious approach when prescribing atypical antipsychotics,so as to prevent TS.

关 键 词：ANTIPSYCHOTIC Tardive syndrome Tardive sensory syndrome LURASIDONE Case report 

分 类 号：R969[医药卫生—药理学]