CHLORPROMAZINE

作品数:20被引量:48H指数:4
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相关作者:邓晓军郭德华朱坚李波张志鸿更多>>
相关机构:上海出入境检验检疫局复旦大学上海市公共卫生临床中心重庆医科大学更多>>
相关期刊:《Liver Research》《Journal of Pharmaceutical Analysis》《Asian Pacific Journal of Tropical Medicine》《Journal of Wuhan University of Technology(Materials Science)》更多>>
相关基金:国家自然科学基金国家高技术研究发展计划重庆市自然科学基金更多>>
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Inhibitory Effect of 5-Adenylic Acid on Bitter Taste of Antipsychotic Drugs
《Pharmacology & Pharmacy》2022年第10期429-446,共18页Jun Kawahara Rio Uno Honami Kojima Miyako Yoshida Takahiro Uchida Hidekazu Ikezaki Masaaki Habara 
The purpose of the present study was to examine the effect of adenylic acid (adenosine 5-monophosphate;AMP), a known nutritional enhancer, on inhibiting the bitterness of antipsychotic medicines administered to patien...
关键词:Adenylic Acid BITTERNESS Antipsychotic Medicine AMITRIPTYLINE CHLORPROMAZINE HALOPERIDOL RISPERIDONE Taste Sensor Drug-Drug Interaction 
History of the dopamine hypothesis of antipsychotic action被引量:2
《World Journal of Psychiatry》2021年第7期355-364,共10页Mary V Seeman 
The dopamine hypothesis of how antipsychotic drugs exert their beneficial effect in psychotic illness has an interesting history that dates back to 1950.This hypothesis is not to be confused with the dopamine hypothes...
关键词:CHLORPROMAZINE HALOPERIDOL G-Protein coupled receptors Binding assays Receptor imaging High affinity states 
Chlorpromazine protects against acetaminophen-induced liver injury in mice by modulating autophagy and c-Jun N-terminal kinase activation被引量:8
《Liver Research》2019年第1期65-74,共10页Yuan Li Hong-Min Ni Hartmut Jaeschke Wen-Xing Ding 
This research was funded by the USA NIH R01 AA 020518,R01 DK 102142,U01 AA 024733,P20 GM 103549(COBRE),and P30 GM 118247(COBRE)。
Background and aim:Overdose of acetaminophen(APAP)leads to liver injury,which is one of the most common causes of liver failure in the United States.We previously demonstrated that pharmacological activation of autoph...
关键词:Chlorpromazine(CPZ) Acetaminophen(APAP) Drug-induced liver injury NECROSIS Autolysosome HEPATOTOXICITY Glutathione(GSH) Oxidant stress 
Characterization of HJ-PI01 as a novel Pim-2 inhibitor that induces apoptosis and autophagic cell death in triple-negative human breast cancer被引量:8
《Acta Pharmacologica Sinica》2016年第9期1237-1250,共14页Yu-qian ZHAO Yi-qiong YIN Jie LIU Gui-hua WANG Jian HUANG Ling-juan ZHU Jin-hui WANG 
Aim: Pim-2 is a short-lived serine/threonine kinase, which plays a key role in metastasis of breast cancer through persistent activation of STAT3. Although the crystal structure of Pim-2 has been reported, but thus f...
关键词:Pim-2 inhibitor HJ-PI01 breast cancer MDA-MB-231 cells APOPTOSIS autophagy CHLORPROMAZINE PIO03 lienal polypeptide 
The inhibition effect of Chlorpromazine against the β-lactam resistance of MRSA
《Asian Pacific Journal of Tropical Medicine》2016年第6期526-530,共5页Ryong Kong Ok-Hwa Kang Yun-Soo Seo Su-Hyun Mun Tian Zhou Dong-Won Shin Dong-Yeul Kwon 
supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF);funded by the Ministry of Education,Science and Technology(2012-0004337)
Objective:To investigate the gene related to β-lactam resistance and to confirm the mechanism about a synergy effect between CPZ and β-lactam antibiotics.Methods:To measure antibacterial activity,we performed a mini...
关键词:CHLORPROMAZINE PBP2A Β-LACTAMASE MECA blaZ MRSA 
Determination of chlorpromazine in porcine muscle using high performance liquid chromatography-tandem mass spectrometry
《Journal of Chinese Pharmaceutical Sciences》2015年第10期690-694,共5页张露 黄雯 蒋心惠 
Chongqing Natural Science Foundation(Grant No.CSCT2013jcyjA10040)
A rapid and accurate high performance liquid chromatography tandem mass spectrometry(HPLS-MS) method was established for quantification of chlorpromazine in pork. The porcine samples were pretreated with acetonitril...
关键词:High performance liquid chromatography-tandem mass spectrometry Chlorpromazine hydrochloride Porcine muscle Residual quantification 
Extraction and determination of trace amounts of chlorpromazine in biological fluids using magnetic solid phase extraction followed by HPLC被引量:10
《Journal of Pharmaceutical Analysis》2014年第4期279-285,共7页Yadollah Yamini Mohammad Faraji 
A simple, rapid and sensitive method termed as magnetic solid phase extraction (MSPE) combined with high-performance liquid chromatography-ultraviolet detector (HPLC-UV) has been proposed for the determination of ...
关键词:CHLORPROMAZINE Magnetic solid phaseextraction 
Oxidation of Amino Acids by Chlorpromazine Cation Radical and Co-Catalysis by Chlorpromazine
《Pharmacology & Pharmacy》2012年第1期29-36,共8页Valdecir F. Ximenes Giovana B. Quaggio Fernanda S. Graciani Manoel L. de Menezes 
The long-tem use of chlorpromazine (CPZ) may cause severe side effects. This property of CPZ might be related to pro-oxidant effects of the chlorpromazine cation radical (CPZ·+), which can be easily generated by cata...
关键词:TRYPTOPHAN TYROSINE Nitrite CHLORPROMAZINE HORSERADISH PEROXIDASE 
Dispersive Liquid-liquid Microextraction Combined with High-performance Liquid Chromatography for the Determination of Clozapine and Chlorpromazine in Urine被引量:3
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2011年第2期277-284,共8页陈静 熊朝梅 阮金兰 苏邹 
supported by Science Research Funds of Medical Course, HUST
A simple method has been proposed for the determination of clozapine (CLZ) and chlorpromazine (CPZ) in human urine by dispersive liquid-liquid microextraction (DLLME) in combination with high-performance liquid ...
关键词:dispersive liquid-liquid microextraction CLOZAPINE CHLORPROMAZINE high-performance liquid chromatography human urine 
Activity of chlorpromazine on nfa1 and Mp2CL5 genes of Naegleria fowleri trophozoites
《Health》2011年第3期166-171,共6页Supathra Tiewcharoen Jundee Rabablert Prucksawan Chetannachan Dusit Worawirunwong Virach Junnu Noppamas Pungsub 
Amoeba treatment of patients suffering from pri-mary amoebic meningoencephalitis caused by Naegleria fowleri has not been successful. Dam-aged morphology and effect on genes of N. fowleri as the result of its initial ...
关键词:NAEGLERIA fowleri CHLORPROMAZINE SCANNING Micrograph GENE Expression 
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