HEPATOTOXICITY

作品数：345被引量：1118H指数：17
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相关领域：医药卫生更多>>
相关作者：李燕陆宏尹文琤阙琳玲余四旺更多>>
相关机构：嘉兴市第二医院中南大学中国医药学院北京大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划国家科技支撑计划广东省自然科学基金更多>>
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Cisplatin induces acute liver injury by triggering caspase-3/GSDME-me diate d cell pyroptosis
《Hepatobiliary & Pancreatic Diseases International》2025年第2期177-187,共11页Ping-Ping Wu Xiu-Jin Shen Shu-Sen Zheng 
supported by grants from the National Natural Science Foundation of China(8170060495 and 82170682)。
Background:Cisplatin triggers Gasdermin E(GSDME)cleavage,causing membrane bubble formation,content release,and inflammation.Caspase-3 activation initiates GSDME cleavage,and thus inhibiting this pathway mitigates cisp...
关键词：CISPLATIN PYROPTOSIS HEPATOTOXICITY Gasdermins GSDME 
Processing-induced reduction in dianthrones content and toxicity of Polygonum multiflorum:Insights from ultra-high performance liquid chromatography triple quadrupole mass spectrometry analysis and toxicological assessment
《Animal Models and Experimental Medicine》2025年第4期685-695,共11页Wan-Fang Li Ying Wang Cai-Xia Qiu Jie Li Jie Bao Jian-Bo Yang Hong-Tao Jin 
National Natural Science Foundation of China,Grant/Award Number:81973476;Chinese Society of Toxicology,Grant/Award Number:CST2021CT101。
Background:Polygonum multiflorum-induced liver injury(PM-DILI)has significantly hindered its clinical application and development.Methods:This study investigates the variation in content and toxicity of dian-thrones,t...
关键词：dianthrones HEPATOTOXICITY Polygonum multiflorum Thunb. ultra-high performance liquid chromatography triple quadrupole mass spectrometry(UHPLC-QQQ-MS/MS) zebrafish embryos 
Hepatorenoprotective effects of Lepidium draba L.extracts against cyclophosphamideinduced oxidative injuries in rats via reducing apoptosis and inflammation
《Asian Pacific Journal of Tropical Biomedicine》2025年第2期53-64,I0002,I0003,共14页Yu-Lai You Sheng Zheng Cheng-Jian Zhao Ye-Fei Chang Pei Liu Xue-Li Zeng Lian Liu 
supported by the Basic Research Joint Special General Project of Yunnan Provincial Local Universities(part)(No:202301BA070001-029,202301BA070001-044);Yunnan Province High-level Scientific and Technological Talents and Innovation Team Selection Special Young and Middle-aged Academic and Technical Leaders Reserve Talent Project(No:202405AC350067).
Objective:To investigate the protective effects of Lepidium draba L.(L.draba)on cyclophosphamide(CP)-induced hepatotoxicity and nephrotoxicity in rats.Methods:A total of 36 rats were divided into six groups as follows...
关键词：Lepidium draba CYCLOPHOSPHAMIDE Oxidative stress Antioxidant APOPTOSIS HEPATOTOXICITY NEPHROTOXICITY 
Ferroptosis and Intrinsic Drug-induced Liver Injury by Acetaminophen and Other Drugs: A Critical Evaluation and Historical Perspective
《Journal of Clinical and Translational Hepatology》2024年第12期1057-1066,共10页Hartmut Jaeschke Anup Ramachandran 
supported in part by National Institute of Diabetes and Digestive and Kidney Diseases grants R01 DK102142(HJ)and R01 DK125465(AR),as well as by National Institute of General Medical Sciencesfunded Liver Disease COBRE grants P20 GM103549(HJ)and P30 GM118247(HJ).
Drug-induced hepatotoxicity is a significant clinical issue worldwide.Given the limited treatment options for these liver injuries,understanding the mechanisms and modes of cell death is crucial for identifying novel ...
关键词：Drug hepatotoxicity ACETAMINOPHEN Lipid peroxidation Oxidative stress Ferroptosis Glutathione peroxidase 4 Erastin Ferrostatin-1 METHOTREXATE RIFAMPICIN ISONIAZID Natural products 
Toosendanin:upgrade of an old agent in cancer treatment
《Chinese Journal of Natural Medicines》2024年第10期887-899,共13页LI Shuwei XIONG Qingyi SHEN Yiwen LIN Jiayi ZHANG Lijun WU Ye JIN Jinmei LUAN Xin 
supported by the National Natural Science Foundation of China(Nos.82322073,82304790,and 82173846);China Postdoctoral Innovative Talent Support Program(BX20220213);Shanghai Rising-Star Program(No.22QA1409100);Oriental Scholars of Shanghai(No.TP2022081);Jiangxi Province Thousand Talents Program(No.jxsq2023102168);Young Talent Lifting Project of China Association of Chinese Medicine[No.CACM-(2021-QNRC2-A08)];Shanghai Science and Technology Innovation Action Plan(No.21S11902800);Three-year Action Plan for Shanghai TCM Development and Inheritance Program[Nos.ZY(2021-2023)-0401 and ZY(2021-2023)-0208];Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202004);CAMS Innovation Fund for Medical Sciences(CIFMS)(No.2023-I2M-3-009);Shanghai Sailing Program(Nos.22YF1445000 and 23YF1442600);the National Key R&D Program of China(No.2022YFC3502000);High-level Key Discipline of National Administration of Traditional Chinese Medicine,Innovation team of high-level local universities in Shanghai:Strategic Innovation Team of TCM Chemical Biology,Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine(No.2023YZZ02)。
Toosendanin(TSN),a tetracyclic triterpenoid derived from Melia toosendan and M.azedarach,demonstrates broad application prospects in cancer treatment.Although previously employed as a pesticide,recent studies have rev...
关键词：TOOSENDANIN Cancer therapy HEPATOTOXICITY PROTAC Nano-delivery systems 
Adverse drug reactions of first-line antitubercular drugs:A retrospective study on characteristics,management,factors,and impacts
《Asian Pacific Journal of Tropical Medicine》2024年第10期456-464,共9页Ai Ling Oh Mohd Makmor-Bakry Farida Islahudin Chuo Yew Ting Swee Kim Chan Siew Teck Tie 
Objective:To elucidate the characteristics,management strategies,risk factors,and clinical impacts associated with adverse drug reactions(ADRs)induced by first-line antitubercular drugs to enhance tuberculosis(TB)mana...
关键词：Adverse events Cutaneous reactions HEPATOTOXICITY Gastrointestinal disturbances Risk factors TUBERCULOSIS 
Polylactic acid micro/nanoplastic-induced hepatotoxicity: Investigating food and air sources via multi-omics
《Environmental Science and Ecotechnology》2024年第5期294-308,共15页Hua Zha Shengyi Han Ruiqi Tang Dan Cao Kevin Chang Lanjuan Li 
supported by the National Natural Science Foundation of China(82003441).
Micro/nanoplastics(MNPs)are detected in human liver,and pose significant risks to human health.Oral exposure to MNPs derived from non-biodegradable plastics can induce toxicity in mouse liver.Similarly,nasal exposure ...
关键词：Micro/nanoplastics HEPATOTOXICITY Microbiota dysbiosis Metabolic disruption Transcriptomic dysregulation 
Levisticum officinale extract protects against CCl4-induced hepatotoxicity through anti-inflammatory,anti-fibrotic,and antioxidant properties in rats
《Asian Pacific Journal of Tropical Biomedicine》2024年第8期331-340,共10页Nahid Ghaedi Iran Pouraboli Mansour Mirtadzadini Mohammad-mehdi Moeini-aghtaie 
Objective:To investigate the hepatoprotective effects of Levisticum officinale extract on CCl4-induced hepatotoxicity.Methods:Different doses of Levisticum officinale extract were given orally to rats for 10 days,then...
关键词：Levisticum officinale CCL4 Inflammation Liver toxicity ANTIOXIDANT 
Ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry-characterized extract of Aerides odorata Lour alleviates paracetamol-induced hepatotoxicity in animal model evidenced by biochemical,molecular,and computational studies
《Animal Models and Experimental Medicine》2024年第4期497-522,共26页A.M.Abu Ahmed Md.Atiar Rahman Farjana Sharmen A.S.M.Ali Reza Md.Shahidul Islam Md.Mamunur Rashid Md.Khalid Juhani Rafi Tanvir Ahmed Siddiqui Md.Muzahid Ahmed Ezaj Srabonti Saha Md.Nazim Uddin Walla Alelwani 
Background:Many kinds of orchids have significant health benefits although ade-quate research on their biological functions is yet to be carried out.This study inves-tigated the paracetamol-induced liver damage-protec...
关键词：Aerides odorata animal model mRNA expression PCM-induced hepatotoxicity UPLC-qTOF-MS 
Hepatoprotective effect of Holothuria leucospilota methanolic extract on dimethyl nitrosamine-induced hepatotoxicity in rats
《Animal Models and Experimental Medicine》2024年第4期544-552,共9页Fatemeh Dejan Amineh Daneshi Javad Rajabi Aslani Nasrollah Ahmadi Narges Eskandari Roozbahani Elaham Rahmanian Reza Behmanesh Hamid Reza Gheisari 
supported by Shiraz University,Shiraz,Iran
Background:Complementary medicine is an interesting field for extracting bio-active compounds from various plant and animal sources.The hepatoprotective effect of the methanolic extract of a species of sea cucumber ca...
关键词：dimethyl nitrosamine HEPATOTOXICITY Holothuria leucospilota sea cucumber 
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