NEPHROTOXICITY

作品数:150被引量:280H指数:9
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相关领域:医药卫生更多>>
相关作者:周世文刘世杰刘志红裘奇朱宝铎更多>>
相关机构:卫生部第三军医大学新桥医院中国医药学院南京大学更多>>
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相关基金:国家自然科学基金国家教育部博士点基金国家重点基础研究发展计划更多>>
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Zinc oxide nanoparticles synthesized with Berberis vulgaris L.ameliorate cyclophosphamide-induced nephrotoxicity in rats
《Asian Pacific Journal of Tropical Biomedicine》2025年第4期158-168,共11页Reza Mohammadian Nader Goodarzi Mohsen Akbaribazm Hadi Cheraghi 
Objective:To examine the protective effects of green-synthesized zinc oxide nanoparticles with Berberis vulgaris L.fruit aqueous extract(BVZnONPs)on cyclophosphamide(CP)-induced nephrotoxicity in Wistar rats.Methods:3...
关键词:Nanoparticle Berberis vulgaris L Barberry KIDNEY Zinc oxide CHEMOTHERAPY 
Hydrogen Sulfide Alleviates Lipid Peroxidation-Mediated Carbonyl Stress in Uranium-Intoxicated Kidney Cells via Nrf2/ARE Signaling
《Biomedical and Environmental Sciences》2025年第4期484-500,共17页Jialin Liu Min Wang Rui Zhang Jifang Zheng Xixiu Jiang Qiaoni Hu 
supported by the National Natural Science Foundation of China(No.82160627);the Natural Science Foundation of the Guangxi Autonomous Region(No.2020GXNFSAA297262)。
Objective To explore the protective effects and underlying mechanisms of H_2S against lipid peroxidation-mediated carbonyl stress in the uranium-treated NRK-52E cells.Methods Cell viability was evaluated using CCK-8 a...
关键词:Hydrogen sulfide(H_2S) Carbonyl stress Lipid peroxidation URANIUM NEPHROTOXICITY NRF2 
Hepatorenoprotective effects of Lepidium draba L.extracts against cyclophosphamideinduced oxidative injuries in rats via reducing apoptosis and inflammation
《Asian Pacific Journal of Tropical Biomedicine》2025年第2期53-64,I0002,I0003,共14页Yu-Lai You Sheng Zheng Cheng-Jian Zhao Ye-Fei Chang Pei Liu Xue-Li Zeng Lian Liu 
supported by the Basic Research Joint Special General Project of Yunnan Provincial Local Universities(part)(No:202301BA070001-029,202301BA070001-044);Yunnan Province High-level Scientific and Technological Talents and Innovation Team Selection Special Young and Middle-aged Academic and Technical Leaders Reserve Talent Project(No:202405AC350067).
Objective:To investigate the protective effects of Lepidium draba L.(L.draba)on cyclophosphamide(CP)-induced hepatotoxicity and nephrotoxicity in rats.Methods:A total of 36 rats were divided into six groups as follows...
关键词:Lepidium draba CYCLOPHOSPHAMIDE Oxidative stress Antioxidant APOPTOSIS HEPATOTOXICITY NEPHROTOXICITY 
Stir-Fried Semen Armeniacae Amarum Suppresses Aristolochic AcidⅠ-Induced Nephrotoxicity and DNA Adducts
《Chinese Journal of Integrative Medicine》2025年第2期142-152,共11页LI Cheng-xian XIAO Xiao-he LI Xin-yu XIAO Da-ke WANG Yin-kang WANG Xian-ling ZHANG Ping LI Yu-rong NIU Ming BAI Zhao-fang 
Supported by the National Science and Technology Major Project"Key New Drug Development and Manufacture Program"(No.2018ZX09101002-001-002);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-C-202005);Special Research Project on Health for Logistics in the Military(No.23BJZ33);Innovative Research Groups of National Natural Science Foundation of China(No.81721002)。
Objective:To investigate the protective effects of stir-fried Semen Armeniacae Amarum(SAA)against aristolochic acidⅠ(AAⅠ)-induced nephrotoxicity and DNA adducts and elucidate the underlying mechanism involved for en...
关键词:aristolochic acidⅠ stir-fried Semen Armeniacae Amarum detoxification principles of compatibility metabolic enzymes transporters 
Artificial intelligence-driven strategies for managing renal and urinary complications in inflammatory bowel disease
《World Journal of Nephrology》2025年第1期6-12,共7页Ya-Xiong Guo Xiong Yan Xu-Chang Liu Yu-Xiang Liu Chun Liu 
In this editorial,we discuss the article by Singh et al published in World Journal of Nephrology,stating the need for timely adjustments in inflammatory bowel disease(IBD)patients'long-term management plans.IBD is chr...
关键词:Inflammatory bowel disease Renal complications Artificial intelligence Long-term management NEPHROTOXICITY 
Glyphosate Based-Herbicide Induced Nephrotoxicity through Oxidative Stress and the Imbalance of Osmotic Pressure in Mice
《Biomedical and Environmental Sciences》2024年第12期1453-1457,共5页Lei Qi Jinfeng Zhu Yanbo Qi Hong Chao Yu Cheng Xiaolei Yang Hongjie Li Gang Li Jicheng Liu 
supported by the Fundamental Research Funds for the Department of Education in Heilongjiang Province(Grant No.2020-KYYWF-0037 and No.2019-KYYWF-1277);National Natural Science Foundation of China(No.82103869);Project of Qiqihar Academy of Medical Sciences(Grant No.QMSI2019M-23,No.QMSI2019M-05 and No.2024-ZDPY-003);Technology Plan Joint Guidance Project of Qiqihar(Grant No.LHYD-202007);Doctor Youth Fund of Qiqihar Academy of Medical Sciences(Grant No.QMSI2023B-13);Technology Plan Joint Guidance Project of Qiqihar(Grant No.LSFGG-2024100).
Glyphosate-based herbicides(GBHs)are used for weeding purposes in orchards and rubber plantations,as well as in the cultivation of tea mulberry and genetically modified crops.In recent years,GBH has become the most wi...
关键词:rubber CHELATE RESIDUES 
Spatial metabolomics reveal metabolic alternations in the injured mice kidneys induced by triclocarban treatment
《Journal of Pharmaceutical Analysis》2024年第11期1686-1694,共9页Peisi Xie Jing Chen Yongjun Xia Zian Lin Yu He Zongwei Cai 
supported by National Natural Science Foundation of China(Grant Nos.:22036001 and 22276034).
Triclocarban(TCC)is a common antimicrobial agent that has been widely used in medical care.Given the close association between TCC treatment and metabolic disorders,we assessed whether long-term treatment to TCC at a ...
关键词:TRICLOCARBAN NEPHROTOXICITY Spatial metabolomics MALDI mass spectrometry imaging 
PGC-1α-mediated imbalance of mitochondria-lipid droplet homeostasis in neomycin-induced ototoxicity and nephrotoxicity
《Acta Pharmaceutica Sinica B》2024年第10期4413-4430,共18页Bin Chen Cheng Cheng Yunhao Wu Siyu Li Mo Han Le Zhen Ying Peng Suhan Guo Kaidi Shen Xia Gao Renjie Chai Guangji Wang Fang Zhou 
supported by the National Natural Science Foundation of China(82274014,82330033,82030029,92149304,82101228);the Leading Technology Foundation Research Project of Jiangsu Province(BK20192005,China);National Key R&D Program of China(Nos.2021YFA1101300,2021YFA1101800,and 2020YFA0112503);the Project of State Key Laboratory of Natural Medicines,China Pharmaceutical University(SKLNMZZ202302,China).
Ototoxicity and nephrotoxicity are the most prevalent side effects of aminoglycoside antibiotics(gentamicin,amikacin,neomycin)and platinum anti-tumor drugs(cisplatin,carboplatin).The inner ear and kidney share similar...
关键词:MITOCHONDRIA NEOMYCIN NEPHROTOXICITY OTOTOXICITY Lipid metabolism TRIACYLGLYCEROL PGC-1Α PLIN3 
A polymyxin B loaded hypoxia-responsive liposome with improved biosafety for efficient eradication of bacterial biofilms
《Nano Research》2024年第9期8325-8336,共12页Fang Liu Lingyun Zou Yongcheng Chen Zuolong Liu Yue Huang Qiao Jin Jian Ji 
supported by the National Natural Science Foundation of China(Nos.52293381 and 52273154);the Key Project of Natural Science Foundation of Zhejiang Province(No.LZ23B040002).
Biofilm-associated bacterial infection brings serious threats to global public health owing to serious antibiotic resistance.It is urgently needed to develop innovative strategies to combat biofilm-associated bacteria...
关键词:bacterial biofilm HYPOXIA LIPOSOME polymyxin B NEPHROTOXICITY 
The natural sources,extraction,and nephroprotective function of oleanolic acid and ursolic acid:a review
《Food and Health》2024年第3期20-32,共13页Wen-Ying Chen Hong-Wei Wang Song Yao Yao Zhou Shuang-Chao Liu Xiao Li Shen 
supported by the National Natural Science Foundation of China(82060598,32260587);the Scientific Research Program of Guizhou Provincial Department of Education(QJJ[2023]019);the Science&Technology Program of Guizhou Province(QKHPTRC-CXTD[2022]014);the Excellent Youth Talents of Zunyi Medical University(17zy-006).
Oleanolic acid(OA)and ursolic acid(UA)are commonly present in the cuticular wax of many edible fruits and medicinal herbs.OA and UA belong to the group of bioactive pentacyclic triterpenoids,exhibiting a wide range of...
关键词:oleanolic acid ursolic acid natural sources NEPHROPROTECTIVE NEPHROTOXICITY 
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