The natural sources,extraction,and nephroprotective function of oleanolic acid and ursolic acid:a review  

作　　者：Wen-Ying Chen Hong-Wei Wang Song Yao Yao Zhou Shuang-Chao Liu Xiao Li Shen 

机构地区：[1]School of Public Health,Zunyi Medical University,Zunyi 563000,Guizhou,China [2]Key Laboratory of Maternal&Child Health and Exposure Science of Guizhou Higher Education Institutes,Zunyi 563000,Guizhou,China

出　　处：《Food and Health》2024年第3期20-32,共13页食品和健康（英文）

基　　金：supported by the National Natural Science Foundation of China(82060598,32260587);the Scientific Research Program of Guizhou Provincial Department of Education(QJJ[2023]019);the Science&Technology Program of Guizhou Province(QKHPTRC-CXTD[2022]014);the Excellent Youth Talents of Zunyi Medical University(17zy-006).

摘　　要：Oleanolic acid(OA)and ursolic acid(UA)are commonly present in the cuticular wax of many edible fruits and medicinal herbs.OA and UA belong to the group of bioactive pentacyclic triterpenoids,exhibiting a wide range of beneficial effects including protection for the kidneys,liver,heart,gastrointestinal tract,and spinal cord.Additionally,OA and UA exhibit antioxidant,anti-ferroptotic,anti-apoptotic,anti-inflammatory,anti-tumor,anti-viral,anti-diabetic,anti-microbial,anti-parasitic,analgesic,wound-healing,hypolipidemic,and hypoglycemic properties,often without notable side effects.Due to the extensive array of their positive functions,it is not feasible to thoroughly cover all aspects in this review.Therefore,the primary focus lies on reviewing the natural sources,extraction,and nephroprotective properties of OA and UA.To summarize,current literatures highlight the nephroprotective mechanisms of OA and UA,primarily involving inhibiting oxidative stress,endoplasmic reticulum stress,glycative stress,dyslipidemia,inflammation,apoptosis,pyroptosis,and renal fibrosis,promoting diuresis,as well as fine-tuning autophagy.

关 键 词：oleanolic acid ursolic acid natural sources NEPHROPROTECTIVE NEPHROTOXICITY 

分 类 号：R28[医药卫生—中药学]