OTOTOXICITY

作品数：52被引量：101H指数：7
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相关领域：医药卫生更多>>
相关作者：陈茜杨烨殷泽登何景春吴文知更多>>
相关机构：泸州医学院附属医院泸州医学院四川省骨科医院上海交通大学附属第一人民医院更多>>
相关期刊：《Journal of Otology》《Journal of Pharmaceutical Analysis》《Frontiers of Medicine》《International Journal of Otolaryngology and Head & Neck Surgery》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss被引量：1
《Neural Regeneration Research》2025年第10期3025-3039,共15页Jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai Yin 
supported by the National Natural Science Foundation of China,Nos.81800919(to YX),82171140(to PW);the International Cooperation and Exchange of the National Natural Science Foundation of China,Nos.82020108008(to HS),81720108010(to SY).
Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial spectrum.However,their use leads to irreversible hearing damage by causing apoptosis of hair cells as ...
关键词：DEGENERATION hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome OTOTOXICITY pyroptosis sensorineural hearing loss spiral ganglion neuron 
Inhibition of the cGAS‑STING Pathway Reduces Cisplatin‑Induced Inner Ear Hair Cell Damage
《Neuroscience Bulletin》2025年第3期359-373,共15页Ying Sun Shengyu Zou Xiaoxiang Xu Shan Xu Haiying Sun Mingliang Tang Weijia Kong Xiong Chen Zuhong He 
supported by grants from the National Natural Science Foundation of China(82222017,82271183,and 81970883);the Key Research and Development Program of Hubei Province(2022BCA046);funding from the Fundamental Research Funds for the Central Universities(2042022kf0059).
Although cisplatin is a widely used chemotherapeutic agent,it is severely toxic and causes irreversible hearing loss,restricting its application in clinical settings.This study aimed to determine the molecular mechani...
关键词：OTOTOXICITY Hearing loss cGAS-STING Hair cell Mitochondrial dysfunction 
PGC-1α-mediated imbalance of mitochondria-lipid droplet homeostasis in neomycin-induced ototoxicity and nephrotoxicity
《Acta Pharmaceutica Sinica B》2024年第10期4413-4430,共18页Bin Chen Cheng Cheng Yunhao Wu Siyu Li Mo Han Le Zhen Ying Peng Suhan Guo Kaidi Shen Xia Gao Renjie Chai Guangji Wang Fang Zhou 
supported by the National Natural Science Foundation of China(82274014,82330033,82030029,92149304,82101228);the Leading Technology Foundation Research Project of Jiangsu Province(BK20192005,China);National Key R&D Program of China(Nos.2021YFA1101300,2021YFA1101800,and 2020YFA0112503);the Project of State Key Laboratory of Natural Medicines,China Pharmaceutical University(SKLNMZZ202302,China).
Ototoxicity and nephrotoxicity are the most prevalent side effects of aminoglycoside antibiotics(gentamicin,amikacin,neomycin)and platinum anti-tumor drugs(cisplatin,carboplatin).The inner ear and kidney share similar...
关键词：MITOCHONDRIA NEOMYCIN NEPHROTOXICITY OTOTOXICITY Lipid metabolism TRIACYLGLYCEROL PGC-1Α PLIN3 
Glycodiversification of gentamicins through in vivo glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity
《Acta Pharmaceutica Sinica B》2024年第9期4149-4163,共15页Xinyun Jian Cheng Wang Shijuan Wu Guo Sun Chuan Huang Chengbing Qiu Yuanzheng Liu Peter FLeadlay Dong Liu Zixin Deng Fuling Zhou Yuhui Sun 
the National Key R&D Program of China(2018YFA0903200);the Funds for International Cooperation and Exchange of the National Natural Science Foundation of China(31920103001).
Aminoglycosides(AGs)are a class of antibiotics with a broad spectrum of activity.However,their use is limited by safety concerns associated with nephrotoxicity and ototoxicity,as well as drug resistance.To address the...
关键词：Antibiotic Aminoglycoside biosynthesis Biosynthetic engineering OTOTOXICITY 
Loss of Fascin2 increases susceptibility to cisplatin-induced hearing impairment and cochlear cell apoptosis in mice
《Journal of Otology》2024年第3期133-139,共7页Yan Wang Yingying Liu Yi Xie Jun Luan Rongrong Liu Yongjia Zhu Ying Ma Yi Fan Yan Sun Wenjing Shang Fengchan Han 
supported by the National Natural Science Foundation of China(No.81771020,81570927 and 81271092);Grant for Scientific and Technological Development Plan for Medical and Health in Shandong Province(2019WS341).
Objectives:Deletion of Fscn2 gene in mice has been linked to progressive hearing loss and degeneration of cochlear cells.Cisplatin,an antitumor drug,can cause various side effects,including ototoxicity.The aim of this...
关键词：Fascin2 CISPLATIN Mouse OTOTOXICITY Apoptosis 
Medical Therapy of Hearing Impairment and Tinnitus with Chinese Medicine:An Overview被引量：1
《Chinese Journal of Integrative Medicine》2023年第8期761-768,共8页ZHANG Ying XIE Hui HE Zhong-mei ZHANG Feng LI Ling-long WANG Na MAO De-hong 
The current review gives a comprehensive overview of the recent development in Chinese medicine(CM)for treating several kinds of acquired nerve deafness and tinnitus,as well as links the traditional principle to well-...
关键词：aural ailment caused by noise diabetic hearing impairment PRESBYCUSIS OTOTOXICITY cochlear blood flow review 
Hidden Hearing Loss: Causes, Current Knowledge, and Future Directions
《International Journal of Otolaryngology and Head & Neck Surgery》2023年第3期107-123,共17页Alexandra Jalkh 
Introduction: Hidden hearing loss (HHL) is a type of auditory disorder that affects the auditory neural processing and hearing sensitivity in subjects with normal hearing thresholds. Unlike central auditory processing...
关键词：Hidden Hearing Loss Speech Testing Speech Intelligibility Noise Induced Hearing Loss OTOTOXICITY Schwan’s Cells Ablation 
Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair cells被引量：1
《Frontiers of Medicine》2022年第4期637-650,共14页Gaogan Jia Huanyu Mao Yanping Zhang Yusu Ni Yan Chen 
supported by the National Key R&D Program of China(No.2017YFA0103900);the National Natural Science Foundation of China(Nos.81771010 and 81570911);the Nature Science Foundation(No.17ZR1404600);from Shanghai Science and Technology Committee.
Oxidative stress plays an important role in the pathogenesis of aminoglycoside-induced hearing loss and represents a promising target for treatment.We tested the potential effect of apigenin,a natural flavonoid with a...
关键词：APIGENIN AMINOGLYCOSIDES OTOTOXICITY oxidative stress Nrf2 signaling pathway 
Study of Biological Activity and Toxicity of Thiosemicarbazides Carbohydrate Derivatives by in Silico, in Vitro and in Vivo Methods
《Journal of Agricultural Chemistry and Environment》2022年第1期15-23,共9页Baktygul Ernazarova Taitokur Zhusubaliev Zarylkan Asilbek kyzy Aida Bakirova Gulsara Zhusupbaeva Orozby Akparalieva Zhypargul Abdullaeva Nasibakhon Razykova Asilkan Dzhumanazarova Galina Apryshko Alina Orozmatova 
Computer analysis of N-(β-D-galactopyranosyl)-thiosemicarbazide compounds by in silico method revealed high probability of antibacterial (antimycobacterial), anti-tuberculosis (antituberculosic), antiviral (Influenza...
关键词：Biological Activity Synthesis UREA CARBOHYDRATE Compounds Hyperurcemia OTOTOXICITY Testing Toxicity Anti Tuberculosis ANTITUMOR 
Astaxanthine attenuates cisplatin ototoxicity in vitro and protects against cisplatin-induced hearing loss in vivo被引量：3
《Acta Pharmaceutica Sinica B》2022年第1期167-181,共15页Benyu Nan Zirui Zhao Kanglun Jiang Xi Gu Huawei Li Xinsheng Huang 
financial support by the National Natural Science Foundation of China(82000980)。
Astaxanthine(AST) has important biological activities including antioxidant and antiinflammatory effects that could alleviate neurological and heart diseases, but its role in the prevention of cisplatin-induced hearin...
关键词：Astaxanthine CISPLATIN Hearing loss Mitochondrial OTOTOXICITY Reactive oxygen species Apoptosis 
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