APIGENIN

作品数：60被引量：152H指数：8
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相关领域：医药卫生更多>>
相关作者：鲍洋洋周水洪谢明均石远陆中杰更多>>
相关机构：淄博齐鼎立专利信息咨询有限公司浙江大学医学院附属第一医院重庆医科大学附属第一医院吉林大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划国家教育部博士点基金更多>>
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Apigenin ameliorates CCl_(4)-induced hepatic fibrosis by inhibiting hepatic stellate cell activation via PI3K/AKT/GSK3βpathway in mice
《Asian Pacific Journal of Tropical Biomedicine》2025年第4期141-149,共9页Tao Sun Bao-Ying Wang Xiao-Ying Li Xiu-Zhi Zhang Yan-Fei Lei Shan-Fa Yu Ning-Ning Li 
supported by the grant from Henan Province Science and Technology Research Project(Project No:242102310250,222102310373);Key Research Project Program of Higher Education Institutions in Henan Province(NO 24A32006,22B360003);Medical Science and Technology Tackling Program of Henan Province(NO LHGJ20230677).
Objective:To investigate the effect of apigenin on carbon tetrachloride(CCl_(4))-induced liver fibrosis and elucidate the underlying mechanisms.Methods:A mouse model of CCl_(4)-induced liver fibrosis was used to evalu...
关键词：Liver fibrosis CCl_(4) Hepatic stellate cell PI3K/AKT/GSK3β APIGENIN 
Apigenin facilitates apoptosis of acute lymphoblastic leukemia cells via AMP-activated protein kinase-mediated ferroptosis
《Oncology Research》2025年第2期421-429,共9页CANCAN HE TINGTING ZHANG WEI XIONG SHENGYU WANG XIN SUN 
supported by The National Natural Science Foundation of China(No.31902283);Research Foundation for Master students at the Affiliated Hospital of Zunyi Medical College(No.22-2018).
Background:The outcomes of pediatric patients with acute lymphoblastic leukemia(ALL)remain far less than favorable.While apigenin is an anti-cancer agent,studies on the mechanism by which it regulates ALL cell cycle p...
关键词：Acute lymphoblastic leukemia(ALL) APIGENIN APOPTOSIS AMP-activated protein kinase(AMPK) Ferroptosis 
Apigenin is an anoikis sensitizer with strong anti-metastatic properties in experimental breast cancer
《Food Science and Human Wellness》2024年第4期2221-2233,共13页Ruijie Xu Zhijie Yao Hao Zhang Haitao Li Wei Chen 
supported by the National Natural Science Foundation of China (81773064,31972973,32021005);National Youth 1000 Talents Plan;the Jiangsu Specially-Appointed Professor Program;Jiangsu Province Recruitment Plan for High-level,Innovative and Entrepreneurial Talents (Innovative Research Team);Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province
Loss of susceptibility to anoikis signals is a crucial step in metastasis.Anoikis resistance therefore represents a promising adjuvant therapeutic target for cancer management.In this study,we have conducted a rationa...
关键词：APIGENIN ANOIKIS Breast cancer metastasis Thromboxane A2 
Apigenin ameliorates imiquimod-induced psoriasis in C57BL/6J mice by inactivating STAT3 and NF-κB被引量：3
《Food Science and Human Wellness》2024年第1期211-224,共14页Xianshe Meng Shihong Zheng Zequn Yin Xuerui Wang Daigang Yang Tingfeng Zou Huaxin Li Yuanli Chen Chenzhong Liao Zhouling Xie Xiaodong Fan Jihong Han Yajun Duan Xiaoxiao Yang 
supported by the National Natural Science Foundation of China(NSFC)(81973316,82173807);the China Postdoctoral Science Foundation(2020M681914);the Fund from Tianjin Municipal Health Commission(ZC200093);the Open Fund of Tianjin Central Hospital of Obstetrics and Gynecology/Tianjin Key Laboratory of human development and reproductive regulation(2021XHY01)。
Psoriasis is a chronic autoimmune disease featured by patches on the skin.It is caused by malfunction of immune cells and keratinocytes with inflammation as one of its key features.Apigenin(API)is a natural flavonoid ...
关键词：PSORIASIS APIGENIN IMIQUIMOD Inflammation Signal transducer activator of transcription 3 (STAT3) Nuclear factor-κB(NF-κB) 
Apigenin, a natural flavonoid, promotes autophagy and ferroptosis in human endometrial carcinoma Ishikawa cells in vitro and in vivo被引量：4
《Food Science and Human Wellness》2023年第6期2242-2251,共10页Yancui Liang Qian Zhong Runhui Ma Zhijing Ni Kiran Thakur Jianguo Zhang Zhaojun Wei 
the National Key Research&Development Program of China(2022YFF1100305);the National Natural Science Foundation of Ningxia Province(2021AAC02019);the Major Projects of Science and Technology in Anhui Province(201903a06020021,201904a06020008,202004a06020042,202004a06020052).
Apigenin,a natural flavonoid has been reported against a variety of cancer types.However,it is unclear whether apigenin can promote autophagy and ferroptosis in Ishikawa cells.There are few reports on the mechanism of...
关键词：Flavonoid APIGENIN AUTOPHAGY Ferroptosis Ishikawa cells Tumor growth Endometrial carcinoma 
Anti-diabetic potential of apigenin,luteolin,and baicalein via partially activating PI3K/Akt/GLUT-4 signaling pathways in insulin-resistant HepG2 cells被引量：1
《Food Science and Human Wellness》2023年第6期1991-2000,共10页Lingchao Miao Haolin Zhang Meng Sam Cheong Ruting Zhong Paula Garcia-Oliveira Miguel A.Prieto Ka-Wing Cheng Mingfu Wang Hui Cao Shaoping Nie Jesus Simal-Gandara Wai San Cheang Jianbo Xiao 
supported by National Natural Science Foundation of China(32072212);Multi-Year Research Grant of University of Macao(MYRG2018-00169-ICMS);Science and Technology Development Fund of Macao(FDCT)(0098/2020/A);MICINN supporting the Ramón y Cajal grant for M.A.Prieto(RYC-201722891);Jianbo Xiao(RYC2020-030365-I);Xunta de Galicia supporting the Axudas Conecta Peme,the IN852A 2018/58 Neuro Food Project,the program EXCELENCIA-ED431F 2020/12;the pre-doctoral grants of P.García-Oliveira(ED481A-2019/295);to Ibero-American Program on Science and Technology(CYTED-AQUA-CIBUS,P317RT0003).
Dietary flavonoids are abundant in natural plants and possess multiple pharmacological and nutritional activities.In this study,apigenin,luteolin,and baicalein were chosen to evaluate their anti-diabetic effect in hig...
关键词：APIGENIN LUTEOLIN BAICALEIN Insulin-resistant HepG2 cells Signaling pathway Reactive oxygen species(ROS) Advanced glycation end-products(AGEs) Glycogen synthase kinase(GSK-3β) Glucose transporter protein 4(GLUT4) 
Apigenin ameliorates diabetic neuropathy in rats by modulating the TLR4/MyD88 signaling pathway
《Asian Pacific Journal of Tropical Biomedicine》2023年第11期469-478,I0003,I0004,I0005,I0006,I0008,共15页Yan-Bo Yu Mi-Zhen Qiu Da-Ying Zhang 
Objective:To determine the neuroprotective effects of apigenin against streptozotocin(STZ)-induced diabetic neuropathy(DN).Methods:To induce DN,Wistar rats(150-200 g)were administered with STZ(55 mg/kg,i.p.).Then they...
关键词：APIGENIN Diabetic neuropathy MYD88 NRF2 Proinflammatory cytokines TLR4 
Comparison of Apigenin,Quercetin and Kaempferol Accumulation and Total Flavonoid Content in Leaves,Embryogenic Cultures and Cell Suspension Cultures of Parsley(Petroselinum crispum)
《Phyton-International Journal of Experimental Botany》2023年第10期2807-2823,共17页Laura Isabel Arias-Rodríguez Martha Alicia Rodríguez-Mendiola Carlos Arias-Castro Federico Antonio Gutiérrez Miceli Diana Reséndez Pérez María Celina Luján Hidalgo Juan JoséVillalobos Maldonado Norma Alejandra Mancilla Margalli 
supported by financial assistance from Smart Biotechnology S.A.de C.V.We gratefully acknowledge their contribution and support in the form of funding for this research project.
In recent years,there has been a growing interest in exploring alternative treatments for bone defects.Bone tissue engineering has turned its attention to plant extracts containing osteogenic flavonoids as potential p...
关键词：Parsley(Petroselinum crispum)cultures osteogenic flavonoids bone regeneration aqueous extracts 
Construction of cyclodextrin-based organic frameworks with adjustable size:Enhanced the physicochemical stability and controlled release characteristics of apigenin
《Food Bioscience》2023年第3期1967-1973,共7页Ming Yin Maoshen Chen Bor-Sen Chiou Fei Liu 
supported by National Natural Science Foundation of China(32272470);the Fundamental Research Funds for the Central Universities(JUSRP12005);the Soft Science Research Project of Wuxi Science and Technology Association(KX-22-C053);supported by 111 project-B07029;national first-class discipline program of Food Science and Technology(JUFSTR20180204);the program of“Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province”,China.
The poor physicochemical stability and bioavailability of apigenin were main factors that limited its application in the food industry.Theγ-cyclodextrin-metal-organic frameworks(γ-CD-MOFs)were prepared using polyeth...
关键词：Metal-organic frameworks PEG APIGENIN Stability Controlled release 
Role of apigenin in high glucose-induced retinal microvascular endothelial cell dysfunction via regulating NOX4/p38 MAPK pathway in vitro被引量：1
《International Journal of Ophthalmology(English edition)》2023年第4期514-522,共9页Li-Li Liu Zhi-Yi Zhao 
AIM:To investigate the retinoprotective role of Apigenin(Api)against high glucose(HG)-induced human retinal microvascular endothelial cells(HRMECs),and to explore its regulatory mechanism.METHODS:HRMECs were stimulate...
关键词：APIGENIN retinal microvascular endothelial cell GLUCOSE NOX4 p38 MAPK 
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