LUTEOLIN

作品数：86被引量：233H指数：8
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相关领域：医药卫生生物学更多>>
相关作者：祝春华乔会敏张祥建赵宗彬李文仿更多>>
相关机构：中国药科大学河北医科大学第二医院浙江大学南京师范大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划国家教育部博士点基金北京市自然科学基金更多>>
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Deficiency of circadian gene Per2 blocks luteolin-induced adipocyte browning in mice through weakening liver PPARα/RXRα/FGF21 pathway
《Food Science and Human Wellness》2025年第3期892-901,共10页Shanshan Shui Juan Chen Yan Lin Jingjing Yuan Xin Wang Xian Zhang Jian Liu Lei Zheng 
During the development of diet-induced obesity,the change of energy matebolism is closely related to the function of the circadian clock in mammals.Luteolin(LU),one of the most common natural flavonoids riched in many...
关键词：Obesity Circadian clock LUTEOLIN Per2 gene Adipose tissue browning 
Luteolin,a common flavone in vegetables,acts as a hormetin possessing neurotrophic function:signaling mediated by inducing mitochondrial stress
《Food Science and Human Wellness》2025年第2期569-580,共12页Alex Xiong Gao Tracy Chenxi Xia Maggie Suisui Guo Gary Kawing Yuen Kevin Qiyun Wu Tina Tingxia Dong Karl Wah-Keung Tsim 
supported by Hong Kong RGC-GFC 16100921;Hong Kong RGC Theme-based Research Scheme(T13-605/18-W);Hong Kong Innovation Technology Fund(PRP/076/20FXITCPD/17-9,MHP/004/21);PD18SC01 and HMRF18SC06;HMRF20SC07,AFD20SC01;Shenzhen Science and Technology Innovation Committee(ZDSYS201707281432317)。
This study aims to uncover the hormetic process of luteolin,a common dietary flavone,in neuronal cells through its role in inducing mitochondrial stress.In rat pheochromocytoma PC12 cells,luteolin at low concentration...
关键词：Flavonoids HORMESIS Mitochondrial membrane potential Autophagy MITOPHAGY 
Luteolin ameliorates chronic stress-induced depressive-like behaviors in mice by promoting the Arginase-1^(+)microglial phenotype via a PPARγ-dependent mechanism
《Acta Pharmacologica Sinica》2025年第3期575-591,共17页Nai-jun Yuan Wen-jun Zhu Qing-yu Ma Min-yi Huang Rou-rou Huo Kai-jie She Jun-ping Pan Ji-gang Wang Jia-xu Chen 
supported by the National Natural Science Foundation of China(Nos.82304990,82474365 and 81973748);the Key Program of National Natural Science Foundation of China(No.82430126);the National Key R&D Program of China(No.2023YFE0209500);the China Postdoctoral Science Foundation(No.2023M732380);the Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine(No.202102010014);the National Training Program of Innovation and Entrepreneurship for Undergraduates,China(No.202310559128);Huang Zhendong Research Fund for Traditional Chinese Medicine of Jinan University.
Accumulating evidence shows that neuroinflammation substantially contributes to the pathology of depression,a severe psychiatric disease with an increasing prevalence worldwide.Although modulating microglial phenotype...
关键词：depression LUTEOLIN NEUROINFLAMMATION MICROGLIA PPARY PHAGOCYTOSIS 
Luteolin-7-diglucuronide,a novel PTP1B inhibitor,ameliorates hepatic stellate cell activation and liver fibrosis in mice
《Acta Pharmacologica Sinica》2025年第1期122-133,共12页Bi-xi Tang Yong Zhang Dan-dan Sun Qin-yi Liu Cong Li Pei-pei Wang Li-xin Gao Xue-mei Zhang Jia Li Wei-liang Zhu Yi Zang 
This article was supported by Shanghai lnstitute of Materia Medica,Chinese Academy of Sciences(No.CASIMM0120225006-2,SIMM0120232001);Shanghai Municipal Science and Technology Major Project(TM202301H002);Shanghai Committee of Science and Technology(22ZR1415200).
Liver fibrosis,one of the leading causes of morbidity and mortality worldwide,lacks effective therapy.The activation of hepatic stellate cells(HSCs)is the dominant event in hepatic fibrogenesis.Luteolin-7-diglucuronid...
关键词：liver fibrosis PHYTOCHEMICAL luteolin 7-diglucuronide HSC activation PTP1B 
Luteolin protects against myocardial ischemia/reperfusion injury by reducing oxidative stress and apoptosis through the p53 pathway
《Journal of Integrative Medicine》2024年第6期652-664,共13页Pan Zhai Xiao-hu Ouyang Meng-ling Yang Lan Lin Jun-yi Li Yi-ming Li Xiang Cheng Rui Zhu De-sheng Hu 
financially supported by grants from the National Natural Science Foundation of China(No.82104488,81974249,82274317,and 82161138003)。
Objective:Myocardial ischemia/reperfusion injury(MIRI)is an obstacle to the success of cardiac reperfusion therapy.This study explores whether luteolin can mitigate MIRI by regulating the p53 signaling pathway.Methods...
关键词：P53 signaling pathway Myocardial ischemia/reperfusion injury APOPTOSIS Oxidative stress LUTEOLIN Network pharmacology 
Luteolin ameliorates ulcerative colitis in mice via reducing the depletion of NCR+ILC3 through Notch signaling pathway
《Chinese Journal of Natural Medicines》2024年第11期991-1002,共12页XIE Xueqian LI Pengcheng ZHAO Meng XU Bo ZHANG Guixing WANG Qing NI Chen LUO Xia ZHOU Lian 
supported by the National Natural Science Foundation of China(No.82074092);the Natural Science Foundation of Guangdong Province(No.2021A1515012219);Guangzhou University of Chinese Medicine“Double First-Class”and High-level University Discipline Collaborative Innovation Team Project(No.2021xk81).
The disorder of group 3 innate lymphoid cells(ILC3)subgroup,such as the predominance of NCR-ILC3 but the deple-tion of NCR+ILC3,is unfavorable to damaged intestinal barrier repair,which leads to the prolongations and ...
关键词：LUTEOLIN Ulcerative colitis Group 3 innate lymphoid cells NOTCH1 RBPJ 
Luteolin alleviates sorafenib-induced ferroptosis of BRL-3A cells through modulation of the Nrf2/GPX4 signaling pathway
《Traditional Medicine Research》2024年第10期1-9,共9页Bo-Wen Zhang Di Yang Jin-Tao Li Mei-Hao Peng Jia-Qing Liao Qi Zhao Yi-Xi Yang Qiu-Xia Lu 
supported by the open fund of State Key Laboratory of Southwestern Chinese Medicine Resources(No.SCMR202103)to Jian Li;Tibet Autonomous Region Science and Technology Plan(high-tech social development)project(No.XZ202201ZY0031G)to Yang YX;Anti-infective Agent Creation Engineering Research Centre of Sichuan Province,Sichuan Industrial Institute of Antibiotics,School of pharmacy,Chengdu University(No.AAC2023002)to Lu QX.
Background:Luteolin is a flavonoid chemical that exists in a variety of medicinal and edible plants and holds many biologically active properties in liver protection,anti-cancer,antioxidants,anti-inflammatory,neuropro...
关键词：LUTEOLIN SORAFENIB liver injury ferroptosis Nrf2/GPX4 
Luteolin promotes neuronogenesis in hippocampus of chronic unpredictable mild stress rats and primary hippocampus of fetal rats
《Journal of Traditional Chinese Medicine》2024年第4期670-679,共10页LIU Tongtong ZHANG Xi YANG Hui LIN Xiaoyuan LIU Jian ZHANG Xiuli GUO Dongwei ZHAO Hongqing ZOU Manshu LEI Chang LONG Hongping LUO Yan XIANG Yun GE Jinwen WANG Yuhong MENG Pan 
Outstanding Youth Project of Natural Science Foundation of Hunan Province:Mechanisms of Emotional-behavioural and Cognitive Impairment in Depression and Intervention with Traditional Chinese Medicine(No.2020JJ3027);the Training Plan of Outstanding Innovative Youth of Changsha(No.kq2009018);Key Projects of Hunan Provincial Department of Education:Hspa5/Pr Pcbased Study on the Mechanism of Lymphoid System Damage in Cerebral Small Vessel Disease with Depression and Intervention with Traditional Chinese Medicine(23A0281);Traditional Chinese Medicine Research Program Project of Hunan Province:Mechanisms of Impairment of Ventral and Dorsal Hippocampal Differential Function in Depression based on Sonic Hedgehog/Brain-Derived Neurotrophic Factor Signalling-Mediated Synaptogenesis in Newborn Neurons and Intervention with Traditional Chinese Medicine(B2023021);Open Fund Project of State Key Laboratory of Traditional Chinese Medicine Powder and Innovative Drugs:Mechanisms of Glymphatic Iinjury in Cerebral Small Vessel Disease with Depression Based on Aquaporin Protein-4 Signalling-Mediated Astrocyte-Responsive Hyperplasia and Intervention with Traditional Chinese Medicine(23PTKF1013)。
OBJECTIVE:To investigate the effects of luteolin on chronic unpredictable mild stress(CUMS)-induced depressive rats and corticosterone(CORT)-induced depressive primary hippocampal neurons,and to elucidate the mechanis...
关键词：FETAL RATS SURVIVAL 
Unraveling the therapeutic mechanisms of myristic acid and luteolin 7-rutinoside in oral cancer: insights from network pharmacology and molecular docking analysis
《Pharmacology Discovery》2024年第2期1-9,共9页Ansari Vikhar Danish Ahmad Misba Ruhi Syed Ayaz Ali Qazi Yasar Mohd.Mukhtar Khan Subur W Khan Mohammed Imran Anees 
Background:The compound Luteolin-7-rutinoside(L7R)is a flavone derivative of luteolin,predominantly identified in plant species belonging to the families Asteraceae.Conversely,Myristic acid is characterized by its str...
关键词：myristic acid luteolin 7-rutinoside network pharmacology oral cancer molecular docking 
Enhancement of porcine in vitro embryonic development through luteolin‑mediated activation of the Nrf2/Keap1 signaling pathway
《Journal of Animal Science and Biotechnology》2024年第2期600-613,共14页Se-Been Jeon Pil-Soo Jeong Min Ju Kim Hyo-Gu Kang Bong-Seok Song Sun-Uk Kim Seong-Keun Cho Bo-Woong Sim 
supported by the Korea Research Institute of Bioscience and Biotechnology(KRIBB)Research Initiative Program(KGM4252331,KGM5382322),Republic of Korea.
Background Oxidative stress,caused by an imbalance in the production and elimination of intracellular reactive oxygen species(ROS),has been recognized for its detrimental effects on mammalian embryonic development.Lut...
关键词：LUTEOLIN Mitochondrial function Nrf2/Keap1 signaling pathway Oxidative stress Porcine embryo development 
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