云南高校图书馆联盟文献共享服务平台- PPARY

PPARY: 作品数：38被引量：203H指数：9; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：沈晓波钱颖范春雷沃兴德宋家梁更多>>; 相关机构：锦州医科大学上虞市中医院哈尔滨医科大学武汉大学更多>>; 相关期刊：《海峡药学》《中国医院院长》《中国医药导报》《Current Medical Science》更多>>; 相关基金：国家自然科学基金广东省自然科学基金国家重点基础研究发展计划国家中医药管理局基金资助项目更多>>

Luteolin ameliorates chronic stress-induced depressive-like behaviors in mice by promoting the Arginase-1^(+)microglial phenotype via a PPARγ-dependent mechanism: 《Acta Pharmacologica Sinica》2025年第3期575-591,共17页Nai-jun Yuan Wen-jun Zhu Qing-yu Ma Min-yi Huang Rou-rou Huo Kai-jie She Jun-ping Pan Ji-gang Wang Jia-xu Chen; supported by the National Natural Science Foundation of China(Nos.82304990,82474365 and 81973748);the Key Program of National Natural Science Foundation of China(No.82430126);the National Key R&D Program of China(No.2023YFE0209500);the China Postdoctoral Science Foundation(No.2023M732380);the Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine(No.202102010014);the National Training Program of Innovation and Entrepreneurship for Undergraduates,China(No.202310559128);Huang Zhendong Research Fund for Traditional Chinese Medicine of Jinan University.; Accumulating evidence shows that neuroinflammation substantially contributes to the pathology of depression,a severe psychiatric disease with an increasing prevalence worldwide.Although modulating microglial phenotype...; 关键词：depression LUTEOLIN NEUROINFLAMMATION MICROGLIA PPARY PHAGOCYTOSIS

PPARy受体激动剂罗格列酮对形觉剥夺性近视和正常豚鼠屈光度的影响: 《眼科新进展》2022年第5期347-352,共6页赵婧妍李兵; 目的探讨过氧化物酶体增殖物激活受体y(PPARy)激动剂罗格列酮在豚鼠形觉剥夺性近视(FDM)中的作用。方法选取40只3周龄豚鼠(均为右眼),随机分成4组正常组、FDM组、正常+罗格列酮组、FDM+罗格列酮组,其中正常组豚鼠不做处理,FDM组豚鼠使...; 关键词：PPARY 形觉剥夺性近视豚鼠罗格列酮

Activating PPARy Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia被引量：4: 《Current Medical Science》2020年第1期55-62,共8页Hang HANG Li-kun WANG Si-ying REN An-jun SONG Guo-feng WU; grants from the National Natural Science Foundation of China(No.81560222);the Guizhou Science and Technology Foundation(No.[2017]7187,and No.[2013]2043).; The present study aimed to explore the molecular mechanisms underlying the increase of nicotinamide adenine dinucleotide phosphate:quinine oxidoreductase 1(NQO1)and y-glutamylcysteine synthetase(γ-GCS)in brain tissue...; 关键词：ROSIGLITAZONE peroxisome proliferator-activated receptor y nuclear factor E2-related factor 2 nicotinamide adenine dinucleotide phosphate:quinine oxidoreductase γ-glutamylcysteine synthetase

Astragaloside IV ameliorates neuroinflammation- induced depressive-like behaviors in mice via the PPARY/NF-κB/NLRP3 inflammasome axis被引量：32: 《Acta Pharmacologica Sinica》2018年第10期1559-1570,共12页Mei-ting SONG Jie RUAN Ru-yi ZHANG Jie DENG Zhan-qiang MA Shi-ping MA; Major depressive disorder is a common but devastating mental disorder, and recent evidence shows that neuroinflammation may play a pivotal role in the etiology of depression. Astragaloside IV （AS-IV） is an active co...; 关键词：astragaloside IV depression PPARY GSK3Β NF-ΚB NLRP3 inflammasome NEUROINFLAMMATION

Tanshinol alleviates impaired bone formation by inhibiting adipogenesis via KLF15/PPARγ2 signaling in GIO rats被引量：12: 《Acta Pharmacologica Sinica》2018年第4期633-641,共9页Ya-jun YANG Zhu ZHU Dong-tao WANG Xin-le ZHANG Yu-yu LIU Wen-xiu LAI Yu-lin MO Jin LI Yan-long LIANG Zhuo-qing HU Yong-jie YU Liao CUI; Glucocorticoid （GC）-induced osteoporosis （GIO） is characterized by impaired bone formation, which can be alleviated by tanshinol, an aqueous polyphenol isolated from Salvia miltiorrhiza Bunge. In this study we inv...; 关键词：glucocorticoid-induced osteoporosis （GIO） tanshinol RESVERATROL bone formation Kruppel-like factor 15 （KLF 15） PPARy 2 ADIPOGENESIS

木犀草苷对3T3-L1前脂肪细胞分化的抑制作用被引量：3: 《中国医药导报》2017年第2期16-19,共4页李慧玲吴骁王丹张秋华; 辽宁省沈阳市科技计划项目(F16-205-1-31); 目的观察木犀草苷对3T3-L1前脂肪细胞分化的抑制作用。方法用噻唑蓝(MTT)法检测木犀草苷对3T3-L1前脂肪细胞增殖的影响;用鸡尾酒法诱导3T3-L1细胞分化,用油红O染色、三酰甘油含量检测脂肪细胞分化程度;采用RT-PCR和Western blot方法检...; 关键词：木犀草苷 3T3-L1前脂肪细胞分化 PPARY C/EBPa

2015-45治疗骨质疏松的新疗法: 《药物生物技术》2015年第4期297-297,共1页; 近日,来自斯克利普斯研究所的科学家通过研究开发了一种新型治疗手段,这种方法可以有效促进骨质缺失患者机体成骨细胞的发育。研究者对名为PPARy的蛋白以及其对骨髓干细胞命运的影响进行了研究,PPARy蛋白是一种主要的脂肪调节子,由于间...; 关键词：骨质疏松治疗 PPARY 间质干细胞疗法成骨细胞脂肪组织骨髓干细胞

姜黄素促进RAW264.7源性M1巨噬细胞向替代激活M2表型极化被引量：14: 《西安交通大学学报（医学版）》2015年第2期257-262,共6页陈方圆袁祖贻周娟王欢薛丽郭宁; 国家自然科学基金面上项目(No.18110221)~~; 目的观察姜黄素对LPS和IFNγ诱导的RAW264.7巨噬细胞(M1)极化的影响及机制。方法不同浓度姜黄素(6.25、12.5、25μmol/L)干预LPS和IFNγ诱导的RAW264.7巨噬细胞(M1)12h,同时再加入20μmol/L GW9662与25μmol/L姜黄素共同干预LPS和IFNγ...; 关键词：姜黄素 RAW264.7巨噬细胞巨噬细胞极化 M1/M2表型过氧化物酶体增殖激活物受体y(PPARy) 脂多糖 y干扰素

The PPARy agonist, ros,glitazone, attenuates airway inflammation and remodeling via heme oxygenase-1 in murine model of asthma被引量：9: 《Acta Pharmacologica Sinica》2015年第2期171-178,共8页Jing XU Yan-ting ZHU Gui-zuo WANG Dong HAN Yuan-yuan WU De-xin ZHANG Yun LIU Yong-hong ZHANG Xin-ming XIE Shao-jun LI Jia-mei LU Lu LIU Wei FENG Xiu-zhen SUN Man-xiang LI; Aim： Rosiglitazone is one of the specific PPARy agonists showing potential therapeutic effects in asthma. Though PPARy activation was considered protective in inhibiting airway inflammation and remodeling in asthma, ...; 关键词：ASTHMA OVA-induced asthma PPARY ROSIGLITAZONE HO-1 p21 MMP-2 MMP-9 ZNPP

Methanolic extract of Momordica cymbalaria enhances glucose uptake in L6 myotubes in vitro by up-regulating PPAR-γ and GLUT-4被引量：2: 《Chinese Journal of Natural Medicines》2014年第12期895-900,共6页Puttanarasaiah Mahesh Kumar Marikunte V Venkataranganna Kirangadur Manjunath Gollapalle L Viswanatha Godavarthi Ashok; supported by Padmashree Institute of Information Sciences,Bangalore; The present study was undertaken to evaluate the influence of the methanolic fruit extract of Momordica cymbalaria （MFMC） on PPARγ, （Peroxisome Proliferator Activated Receptor gamma） and GLUT-4 （Glucose transpor...; 关键词：Momordica cymbalaria DIABETES Glucose transport PPARY L6 myotubes Antidiabetic activity

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