云南高校图书馆联盟文献共享服务平台- ROSIGLITAZONE

ROSIGLITAZONE: 作品数：89被引量：301H指数：10; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：陈白莉盛春君陈胜广吴国亭廖山婴更多>>; 相关机构：中南大学湘雅二医院华中科技大学北京大学中山大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金国家高技术研究发展计划更多>>

Size-dependent macrophage-targeting of mannose-modified rosiglitazone liposomes to alleviate inflammatory bowel disease被引量：2: 《Chinese Chemical Letters》2024年第1期385-391,共7页Erjin Wang Run Han Mingyue Wu Yuan He Yaxin Cheng Jiahong Lu Ying Zheng; the Macao Science and Technology Development Fund(No.0086/2021/A2);Shenzhen Fundamental Research Program(No.SGDX20210823103804030);the 2020 Guangdong Provincial Science and Technology Innovation Strategy Special Fund(Guangdong-Hong Kong-Macao Joint Lab,No.2020B1212030006);Guangdong Basic and Applied Basic Research Foundation(No.2022A1515012416).; Inflammatory bowel disease (IBD) is a refractory chronic intestinal inflammatory disease caused by a malfunction of immune system. As the key immune cells in the intestine, macrophages play an important role in mainta...; 关键词：Macrophage targeting Liposome MANNOSE Particle size Inflammatory bowel disease

Activation of the endocannabinoid system mediates cardiac hypertrophy induced by rosiglitazone: 《Acta Pharmacologica Sinica》2022年第9期2302-2312,共11页Ya-han Liu Yan Liu Xu Zhang Li Fang Bei-lei Zhao Nan-ping Wang; This study was supported by grants from the National Key R&D Program of China[2018YFA0800600];National Science Foundation of China[81830015,82170422 and 81670408].; Rosiglitazone(RSG)is a synthetic agonist of peroxisome proliferator-activated receptor-γ(PPARγ),which plays a central role in the regulation of metabolism.Meta-analyses have suggested that RSG is associated with inc...; 关键词：peroxisome proliferator-activated receptor-γ ENDOCANNABINOIDS cardiac hypertrophy mammalian target of rapamycin

Rosiglitazone disrupts pancreatic ductal adenocarcinoma progression by activating the tumor suppressor ESE3/EHF被引量：1: 《Cancer Biology & Medicine》2022年第7期945-947,共3页Hongquan Wang Shuang Wu Yan Wang Bo Tang; supported partly by the National Natural Science Foundation of China(Grant Nos.81871938 and 82173118);Guangxi Natural Science Foundation for Key Program of Research&Development(Grant No.GuiKe AB21075003);Guangxi Natural Science Foundation for Guangdong-Guangxi United Program(Grant No.2021GXNSFDA075014).; Pancreatic ductal adenocarcinoma(PDAC),the most common histologic type of pancreatic cancer,is among the most lethal cancers,and is associated with poor prognosis because of its inherent chemoresistant nature and meta...; 关键词：ADENOCARCINOMA DUCTAL SUPPRESSOR

The Activation of Peroxisome Proliferator-activated ReceptorγEnhances Insulin Signaling Pathways Via Up-regulating Chemerin Expression in High Glucose Treated HTR-8/SVneo Cells被引量：1: 《Maternal-Fetal Medicine》2020年第3期131-140,共10页Zhou Xuan Wei Li-Jie Li Jia-Qi Zhang Jing-Yi Zhu Sheng-Lan Zhang Hui-Ting Jia Jing Yu Jun Wang Shao-Shuai Feng Ling; This study was supported by the National Key R&D Program of China(No.2016YFC1000405 and No.2018YFC1002903); Objective:To investigate whether peroxisome proliferator-activated receptorγ(PPARγ)agonists,rosiglitazone and GW1929,activate the phosphatidylinositol 3-kinase(PI3K)-AKT/protein kinase B pathway and the mitogen-acti...; 关键词：GLUCOSE CHEMERIN Chemokine-like receptor 1 G protein-coupled receptor 1 GW1929 Phosphatidylinositol 3-kinase PPAR gamma Protein kinase B beta p42 MAPK ROSIGLITAZONE

Activating PPARy Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia被引量：4: 《Current Medical Science》2020年第1期55-62,共8页Hang HANG Li-kun WANG Si-ying REN An-jun SONG Guo-feng WU; grants from the National Natural Science Foundation of China(No.81560222);the Guizhou Science and Technology Foundation(No.[2017]7187,and No.[2013]2043).; The present study aimed to explore the molecular mechanisms underlying the increase of nicotinamide adenine dinucleotide phosphate:quinine oxidoreductase 1(NQO1)and y-glutamylcysteine synthetase(γ-GCS)in brain tissue...; 关键词：ROSIGLITAZONE peroxisome proliferator-activated receptor y nuclear factor E2-related factor 2 nicotinamide adenine dinucleotide phosphate:quinine oxidoreductase γ-glutamylcysteine synthetase

PPAR-γ activation increases insulin secretion independent of CASK in INS-1 cells: 《Acta Biochimica et Biophysica Sinica》2019年第7期715-722,共8页Kai Zhang Qingzhao Yuan Jinyang Xie Li Yuan Yao Wang; This work was supported by the grant from the National Natural Science Foundation of China (No.81570734 to Y.W.).; Peroxisome proliferator-activated receptor-γ(PPAR-γ) is expressed in pancreatic β cells and is involved in insulin secretion. However, the precise mechanisms remain unclear. Calcium/calmodulin-dependent serine prot...; 关键词：INS-1 cells PPAR-Γ CASK ROSIGLITAZONE

Structure-based design,synthesis,and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors被引量：4: 《Acta Pharmaceutica Sinica B》2018年第4期615-628,共14页Xu-Nian Wu Ya-Dan Huang Jin-Xuan Li Yan-Fa Yu Qian Zhou Chen Zhang Yinuo Wu Hai-Bin Luo; supported by the National Key R&D Program of China (2017YFB0202600);Natural Science Foundation of China (Nos. 81522041,81373258,21572279,81602955,and 21402243);Science Foundation of Guangdong Province (Nos. 2014A020210009,2016A030310144);The Fundamental Research Funds for the Central Universities (Sun Yat-Sen University,No. 17ykjc03 and 17ykpy20);Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme (2016);Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund (the second phase) under Grant No. U1501501 for providing the supercomputing service; The pathological processes of Alzheimer's disease and type 2 diabetes mellitus have been demonstrated to be linked together. Both PDE9 inhibitors and PPARγ agonists such as rosiglitazone exhibited remarkable preclini...; 关键词：PDE9 inhibitors Alzheimer’s disease Type 2 diabetes mellitus ROSIGLITAZONE Molecular docking Dynamics simulation

Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis被引量：2: 《World Journal of Gastroenterology》2017年第22期3999-4006,共8页Robert G Bennett Ronda L Simpson Frederick G Hamel; Supported by The United States Department of Veterans Affairs Biomedical Laboratory Research and Development Program,No.BX000849;National Institutes of Health,NIAAA,No.R01AA015509; To determine the effect of combined serelaxin and rosiglitazone treatment on established hepatic fibrosis.METHODSHepatic fibrosis was induced in mice by carbon tetrachloride administration for 6 wk, or vehicle alone (...; 关键词：RELAXIN Peroxisome proliferator-activated receptors Liver cirrhosis Liver diseases FIBROSIS

Effect of PPARγagonist(rosiglitazone)on the secretion of Th2 cytokine in asthma mice被引量：2: 《Asian Pacific Journal of Tropical Medicine》2017年第1期63-66,共4页Ji-Hui Yu Li Long Zhi-Xiao Luo Jie-Ru You; Supported by medical research project of Health and Family Planning Commission of Chongqing(Grant No.20142019); Objective: To explore the effect of PPAR γ agonist(rosiglitazone) on the secretion of Th2 cytokines and the proportion of immune cell subsets in asthma mice,Methods: Ovalbumin(OVA)-sensitized mice were used to build ...; 关键词：PPAR γ ASTHMA TH2 Treg Th17

Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity被引量：10: 《Journal of Clinical & Translational Research》2017年第1期68-88,共21页Julie Massart Karima Begriche Caroline Moreau Bernard Fromenty; Background:Obesity is often associated with nonalcoholic fatty liver disease(NAFLD),which refers to a large spectrum of hepatic lesions including fatty liver,nonalcoholic steatohepatitis(NASH)and cirrhosis.Different i...; 关键词：obesity nonalcoholic fatty LIVER disease drug LIVER toxicity drug-induced LIVER injury hepatotoxicity cytochrome P450 mitochondria acetaminophen HALOTHANE ISOFLURANE methotrexate tamoxifen PENTOXIFYLLINE ROSIGLITAZONE STAVUDINE

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