SUPPRESSOR

作品数：225被引量：886H指数：16
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相关机构：东南大学中国科学院大学浙江大学吉林大学白求恩第一医院更多>>
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Correction to:Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer
《Protein & Cell》2024年第11期866-866,共1页
This is a correction to:Yuanyuan Gu,Shuoxin Liu,Xiaodan Zhang,Guimin Chen,Hongwei Liang,Mengchao Yu,Zhicong Liao,Yong Zhou,Chen-Yu Zhang,Tao Wang,Chen Wang,Junfeng Zhang,Xi Chen,Oncogenic miR-19a and miR-19b co-regula...
关键词：SUPPRESSOR MIR lung 
Proxitome profiling reveals a conserved SGT1-NSL1 signaling module that activates NLR-mediated immunity被引量：2
《Molecular Plant》2024年第9期1369-1391,共23页Dingliang Zhang Xinxin Yang Zhiyan Wen Zhen Li Xinyu Zhang Chenchen Zhong Jiajie She Qianshen Zhang He Zhang Wenli Li Xiaoyun Zhao Mingliang Xu Zhen Su Dawei Li Savithramma P.Dinesh-Kumar Yongliang Zhang 
supported by grants from the National Natural Science Foundation of China(32320103003 and 32122070);the“High-end Foreign Experts Recruitment Plan”of Ministry of Science and Technology(G2023108007L);Chinese Universities Scientific Fund(2023TC074);Pinduoduo-China Agricultural University Research Fund(PC2023B02012);China National Postdoctoral Program for Innovative Talents(BX20240421);2115 Talent Development Program of China Agricultural University.
Suppressor of G2 allele of skp1(SGT1)is a highly conserved eukaryotic protein that plays a vital role in growth,development,and immunity in both animals and plants.Although some SGT1 interactors have been identified,t...
关键词：suppressor of G2 allele of skp1 SGT1 proximity labeling N NLR immune receptor Necrotic Spotted Lesion 1 NSL1 salicylic acid UBIQUITINATION 
Hepatitis B virus core protein as a Rab-GAP suppressor driving liver disease progression被引量：1
《Science Bulletin》2024年第16期2580-2595,共16页Yu Su Fan Bu Yuanfei Zhu Le Yang Qiong Wu Yuan Zheng Jianjin Zhao Lin Yu Nan Jiang Yongxiang Wang Jian Wu Youhua Xie Xinxin Zhang Yueqiu Gao Ke Lan Qiang Deng 
supported by the Shanghai Municipal Science and Technology Major Project(ZD2021CY001);the National Natural Science Foundation of China(82372233,82072279,81871647,and 82205055);the Innovation Fund for Medical Sciences from Chinese Academy of Medical Sciences(2019-I2M-5-040).
Chronic hepatitis B virus(HBV)infection can lead to advanced liver pathology.Here,we establish a transgenic murine model expressing a basic core promoter(BCP)-mutated HBV genome.Unlike previous studies on the wild-typ...
关键词：APOPTOSIS Basic core promoter MITOPHAGY Rab7 Transgenic mice 
Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation
《Cell Research》2024年第7期522-525,共4页Xianwen Ye Zixuan Huang Yi Li Mengjiao Wang Wanyu Meng Maojian Miao Jingdong Cheng 
the Center of Cryo-EM at Fudan University for technical support.This research was supported by grants from the National key R&D Program of China(2023YFC2413204);the National Natural Science Foundation of China(32371350);Shanghai Municipal Science and Technology Commission grants(22410712400,22ZR1413600)to J.C.
Dear Editor,Protein translation regulation is a crucial and tightly controlled regulatory process that contributes to phenotypic diversity among cells with identical or similar genotypes.Across all the steps of transl...
关键词：SUPPRESSOR TRANSLATION rigorous 
PHLDA2 is critical for p53-mediated ferroptosis and tumor suppression
《Journal of Molecular Cell Biology》2024年第7期60-62,共3页Xin Yang Wei Gu 
Dear Editor,Inactivation of the tumor suppressor p53 is a pivotal event in the formation of most human cancers.Dissecting the precise mechanism of p53 in tumor suppression contributes to the development of a better st...
关键词：P53 SUPPRESSOR PRECISE 
JW-1-283 inhibits melanoma tumor growth via stabilization of the p53 pathway
《Genes & Diseases》2024年第3期18-21,共4页Yang Xie Ruida Hou Kelli LHartman Jianxiong Jiang Zhongzhi Wu Wei Li 
supported by National Institutes of Health(NIH)grant R01CA240447 to W.L.
Melanoma is a lethal skin malignancy and the fifth most diagnosed cancer in the United States.1 Currently,for unresectable melanoma,the recommended treatment options include checkpoint inhibitor immunotherapy targetin...
关键词：MELANOMA SUPPRESSOR DEATH 
DNA methylation profiles in cancer:functions,therapy,and beyond
《Cancer Biology & Medicine》2024年第2期111-116,共6页Jinrong Zhu Yongjie Yang Li Li Jiuren Tang Rongxin Zhang 
DNA methylation in cancer DNA methylation,a reversible post-replication modification,defines gene expression and function in different physiologic processes.Hypomethylation is quite common among global DNA modificatio...
关键词：CANCER SUPPRESSOR thereby 
StSN2 interacts with the brassinosteroid signaling suppressor StBIN2 to maintain tuber dormancy
《Horticulture Research》2023年第12期264-275,共12页Shifeng Liu Chengcheng Cai Luopin Li He Wen Jie Liu Liqin Li Qiang Wang Xiyao Wang 
This work was supported by the Innovation Team Project no.sccxtd-2023-09 of the Modern Agricultural Industrious Technology System of Sichuan Province;the Biological Breeding Project no.SKL-ZY202203 of the State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China.We thank A&L Scientific Editing(www.alpublish.com)for the linguistic assistance during the preparation of this manuscript.
After harvest,potato tubers undergo an important period of dormancy,which significantly impacts potato quality and seed vigor.StSN2 has been reported as a key gene for maintaining tuber dormancy;in this study,we explo...
关键词：DORMANCY MAINTAIN fir 
The role of targeting protein for Xklp2 in tumorigenesis of hepatocellular carcinoma
《Hepatobiliary & Pancreatic Diseases International》2023年第4期418-422,共5页Ting Li Lu-Jian Zhu An-Min Huang Yi-Feng Wei Jun Xu Ye-Jin Xu 
supported by a grant from Zhejiang Province Public Welfare Technology Application Research Funding Project(GD22H036691).
To the Editor:Hepatocellular carcinoma(HCC)is a prevalent form of gastrointestinal malignancies.The current combination of immunotherapy and other treatments improves overall survival compared to conventional therapie...
关键词：DRUGS SUPPRESSOR HEPATOCELLULAR 
Pan-cancer analysis of DNA methyltransferase family with potential implications in prognosis and immunology in human cancer
《Genes & Diseases》2023年第4期1206-1209,共4页Jiayu Ding Hao Shen Dawei Wang Wenbin Kuang Liping Wang Xiao Wang Peng Yang 
supported by National Natural Science Foundation of China(No.82073701,31900687);Natural Science Foundation of Jiangsu Province(China)(No.BK20190551);the Project Program of State Key Laboratory of Natural Medicines,China Pharmaceutical University(No.SKLNMZZ202013);supported by Jiangsu Key Laboratory of Drug Design and Optimization,China Pharmaceutical University(No.2020KFKT-5);“Double First-Class”University Project(China)(No.CPU2018GF04).
DNA methylation,as a key epigenetic modification affecting gene expression,is catalyzed by DNA methyl-transferase(DNMT).DNMT1,DNMT3A,and DNMT3B are the main members of the DNMT family,which have been found to regulate...
关键词：CANCER SUPPRESSOR PROGNOSIS 
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