ADIPOGENESIS

作品数：127被引量：530H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：陈迎春李芳琼朱砺刘海峰张沛更多>>
相关机构：中山大学附属第一医院中山大学上海中医药大学武汉大学更多>>
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Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1 and GPR39 in adipogenesis
《Science China(Life Sciences)》2025年第4期1057-1072,共16页Chuan Ye Xuemei Wang Jun Lin Chenyang Wu Yuhua Gao Chenghao Guo Yunxi Liao Ziyan Rao Shaodong Huang Weixuan Chen Ying Huang Jinpeng Sun Dongyu Zhao Changtao Jiang 
supported by the National Natural Science Foundation of China(32270603,31925021,82130022,92357305,82341226,32271232);the National Key Research and Development Program of China(2021YFF1201100,2018YFA0800701);the Fundamental Research Funds for the Central Universities(BMU2021YJ057)。
Adipogenesis is the healthy expansion of white adipose tissue(WAT),serving as a compensatory response to maintain metabolic homeostasis in the presence of excess energy in the body.Therefore,the identification of nove...
关键词：ADIPOGENESIS GPCRS trajectory inference 
Neonatal vitamin A but not retinoic acid administration increases intramuscular adipocyte number in sheep by promoting vascularization
《Animal Nutrition》2024年第4期215-225,共11页Zhongzuo Huang Xiaoxiao Yu Zongyou Jiang Gaojian Tang Shaoqi Gao Yifan Xiang Yicheng Luo Boping Ye Yating Li Pengkang Song Yu Xin Min Du Junxing Zhao Bo Wang 
supported by grants from the National Natural Science Foundation of China (32272892,31972559);the Key Research and Development Program-Key Projects (2021YFD1200900 and 2023YFD1301302);the Young Talent Supporting Program Funding of the College of Animal Science and Technology,and China Agricultural University Education Foundation Grant(1041-2221002)
This study investigated whether vitamin A(VA)administration during the neonatal stage could increase the number of intramuscular adipocytes in Hu sheep by promoting vascularity.A total of 56 newborn male Hu sheep were...
关键词：SHEEP Vitamin A Retinoic acid Intramuscular fat ADIPOGENESIS Angiogenesis 
Transcriptomic analysis reveals“adipogenesis”in the uterosacral ligaments of postmenopausal women with recurrent pelvic organ prolapse
《中南大学学报(医学版)》2024年第11期1808-1820,共13页ZHOU Yanhua YAN Dayu ZHANG Xiulan LI Xuhong YAN Wenguang JIANG Li 
supported by the Key Research and Development Program of Hunan Province(2023SK2038);the Natural Science Foundation of Hunan Province(2024JJ8121),China。
Objective:Pelvic organ prolapse(POP)is a common condition in postmenopausal women,with an increasing prevalence due to aging.Some women experience POP recurrence after surgical treatment,significantly affecting their ...
关键词：recurrent pelvic organ prolapse uterosacral ligament ADIPOGENESIS INFLAMMATION TRANSCRIPTOMICS 
Lysine 2-hydroxyisobutyrylation levels determined adipogenesis and fat accumulation in adipose tissue in pigs
《Journal of Animal Science and Biotechnology》2024年第5期2093-2105,共13页Enfa Yan Mingyang Tan Ning Jiao Linjuan He Boyang Wan Xin Zhang Jingdong Yin 
financially supported by the National Key Research and Development Program of China(Grant No.2023YFD1301300)。
Background Excessive backfat deposition lowering carcass grade is a major concern in the pig industry,especially in most breeds of obese type pigs.The mechanisms involved in adipogenesis and fat accumulation in pigs r...
关键词：ADIPOGENESIS BACKFAT Fat accumulation 2-Hydroxyisobutyrylation Intramuscular fat content PIGS 
Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity
《Signal Transduction and Targeted Therapy》2024年第9期4120-4136,共17页Lu Fang Changjie Liu Zong-zhe Jiang Mengxiao Wang Kang Geng Yangkai Xu Yujie Zhu Yiwen Fu Jing Xue Wenxin Shan Qi Zhang Jie Chen Jiahong Chen Mingming Zhao Yuxuan Guo K.W.Michael Siu Y.Eugene Chen Yong Xu Donghui Liu Lemin Zheng 
supported by the National High Technology Research and Development Program of China(Grant NO.2020YFA0803700,NO.2023YFA1800904);the Natural Science Foundation of Beijing,China(Grant NO.L232031,NO.J230039);the Natural Science Foundation of China(Grant NO.81970425,NO.32171174,NO.U22A20286,NO.82270358);the Joint Funds from Guangzhou Science and Technology Project(Grant NO.2023A03J0531,NO.2024A03J0658);the Guangzhou Key Discipline of Medicine(Grant NO.ZDXK202103)(Geriatric Medicine,2021-2023);the Key Open Project of Metabolic Vascular Disease Key Laboratory of Sichuan Province(Grant NO.2022MVDKL-K1);the Guangzhou Municipal Science and Technology Project(2023A04J1265).
Obesity is a global issue that warrants the identification of more effective therapeutic targets and a better understanding of the pivotal molecular pathogenesis.Annexin A1(ANXA1)is known to inhibit phospholipase A2,e...
关键词：OBESITY prevention ELEVATED 
The flavonoid glycoside vaccarin inhibits adipogenesis and stimulates lipolysis via Hedgehog signaling in 3T3-L1 adipocytes
《Food and Health》2024年第2期4-13,共10页Cui-Cui Zeng Martin G.Banwell Ping Lan Wei-Min Chen Jing Chen 
This work was graciously supported by the Chinese National Natural Science Foundation(Grant 31901725 and 32201933);the Science and Technology Projects in Guangzhou(Grant 202201010170).
Vaccarin,a flavonoid glycoside isolated from Vaccaria segetalis,is non-toxic to 3T3-L1 cells up to concentrations of 200μM.Accordingly,we investigated the effects of this natural product on adipogenesis and lipolysis...
关键词：ADIPOGENESIS LIPOLYSIS Hedgehog signaling Vaccarin 3T3-L1 adipocytes 
Unraveling the relationship between histone methylation and nonalcoholic fatty liver disease
《World Journal of Hepatology》2024年第5期703-715,共13页Li Xu Yu-Hong Fan Xiao-Jing Zhang Lan Bai 
Non-alcoholic fatty liver disease(NAFLD)poses a significant health challenge in modern societies due to shifts in lifestyle and dietary habits.Its complexity stems from genetic predisposition,environmental influences,...
关键词：Non-alcoholic fatty liver disease MECHANISM Histone methylation METHYLTRANSFERASES Demethytrasferases Epigenetic modification ADIPOGENESIS 
Adipose-derived mesenchymal stem cells(MSCs)are a superior cell source for bone tissue engineering被引量：4
《Bioactive Materials》2024年第4期51-63,共13页Yannian Gou Yanran Huang Wenping Luo Yanan Li Piao Zhao Jiamin Zhong Xiangyu Dong Meichun Guo Aohua Li Ailing Hao Guozhi Zhao Yonghui Wang Yi Zhu Hui Zhang Yunhan Shi William Wagstaff Hue H.Luu Lewis L.Shi Russell R.Reid Tong-Chuan He Jiaming Fan 
by research grants from the Natural Science Foundation of China(82102696 to JF);the Chongqing Bayu Young Scholar Award(JF),the 2019 Chongqing Support Program for Entrepreneurship and Innovation(No.cx2019113 to JF);the 2019 Funding for Postdoctoral Research(Chongqing Human Resources and Social Security Bureau No.298 to JF);the National Institutes of Health(CA226303 to TCH,and DE030480 to RRR);supported by the Medical Scientist Training Program of the National Institutes of Health(T32 GM007281);supported in part by The University of Chicago Cancer Center Support Grant(P30CA014599);the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR002389-07.
Effective bone regeneration through tissue engineering requires a combination of osteogenic progenitors,osteoinductive biofactors and biocompatible scaffold materials.Mesenchymal stem cells(MSCs)represent the most pro...
关键词：Mesenchymal stem cell(MSC) Bone tissue engineering Multipotent progenitor cells Adipose-derived mesenchymal stem cells Osteogenic differentiation ADIPOGENESIS 
Spock1参与Adipogenesis通路在肥大型与扩张型心肌病中的机制探讨
《解剖科学进展》2024年第2期113-116,共4页朱荣利 刘颖 柳明 易玮珏 吴凤敏 侯秀阳 封瑞 
国家自然科学基金(31400981);辽宁省教育厅科学研究经费项目(L202003);2020年大学生创新创业训练项目(x202010159044)。
目的探讨SPARC(骨素)、cwcv和Kazal样结构域蛋白多糖1(Spock1)在肥大型与扩张型心肌病发生中的作用与分子机制。方法基于CNKI数据库明确Spock1在机体各组织中的表达情况,并获得Spock1参与信号通路的关联基因,对此关联基因进行GO和KEGG...
关键词：Spock1 信号通路 心脏疾病 富集分析 
CircDOCK7 facilitates the proliferation and adipogenic differentiation of chicken abdominal preadipocytes through the gga‑miR‑301b‑3p/ACSL1 axis被引量：1
《Journal of Animal Science and Biotechnology》2023年第6期2290-2315,共26页Weihua Tian Ye Liu Wenhui Zhang Ruixue Nie Yao Ling Bo Zhang Hao Zhang Changxin Wu 
the National Key Research and Development Program of China(2021YFD1200803 and 2022YFD1600902);China Agriculture Research System(CARS-40).
Background Abdominal fat deposition depends on both the proliferation of preadipocytes and their maturation into adipocytes,which is a well-orchestrated multistep process involving many regulatory molecules.Circular R...
关键词：Abdominal fat deposition ADIPOGENESIS CHICKENS CircDOCK7 Competing endogenous RNA MiRNA sponge 
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