云南高校图书馆联盟文献共享服务平台- METHYLTRANSFERASES

METHYLTRANSFERASES: 作品数：16被引量：28H指数：3; 导出分析报告; 相关领域：生物学更多>>; 相关作者：吴韦韦庞秋香邓玉林魏玉霞肖盛元更多>>; 相关机构：深圳大学山东理工大学北京理工大学更多>>; 相关期刊：《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Science Bulletin》《分析测试学报》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划山东省高等学校科技计划项目山东省自然科学基金更多>>

Unraveling the relationship between histone methylation and nonalcoholic fatty liver disease: 《World Journal of Hepatology》2024年第5期703-715,共13页Li Xu Yu-Hong Fan Xiao-Jing Zhang Lan Bai; Non-alcoholic fatty liver disease(NAFLD)poses a significant health challenge in modern societies due to shifts in lifestyle and dietary habits.Its complexity stems from genetic predisposition,environmental influences,...; 关键词：Non-alcoholic fatty liver disease MECHANISM Histone methylation METHYLTRANSFERASES Demethytrasferases Epigenetic modification ADIPOGENESIS

Two H3K36 methyltransferases differentially associate with transcriptional activity and enrichment of facultative heterochromatin in rice blast fungus: 《aBIOTECH》2024年第1期1-16,共16页Mengting Xu Ziyue Sun Huanbin Shi Jiangnan Yue Xiaohui Xiong Zhongling Wu Yanjun Kou Zeng Tao; supported by the National Natural Science Foundation of China (32170192 and 32370200 to Z.T);National Youth Talent Support Program.; Di-and tri-methylation of lysine 36 on histone H3(H3K36me2/3)is catalysed by histone methyltransferase Set2,which plays an essential role in transcriptional regulation.Although there is a single H3K36 methyltransferas...; 关键词：Ash1 Facultative heterochromatin H3K36me2/3 Magnaporthe oryzae Set2 Transcriptional regulation

Methylation in hangtaimycin biosynthesis and its antibacterial activities: 《Synthetic and Systems Biotechnology》2023年第4期682-687,共6页Minghe Luo Yulu Dong Zixin Deng Yuhui Sun; supported by National Key R&D Program of China(2018YFA0903200);General Program of National Natural Science Foundation of China(32370083);Natural Science Foundation of Chongqing CSTB(CSTB2022NSCQ-MSX0995);Graduate Innovation Program(GZLCX20232114)。; About two-thirds of small molecule drugs contain methyl group and it plays a very important role in the drug development.So,methyltransferases catalyzing the methylation have always attracted great attention.Hangtaimy...; 关键词：Hangtaimycin METHYLATION S-Adenosylmethionine-dependent METHYLTRANSFERASES FK506 methyltransferase type O-methyltransferase Antibacterial BIOSYNTHESIS

Novel insights into histone lysine methyltransferases in cancer therapy:From epigenetic regulation to selective drugs被引量：1: 《Journal of Pharmaceutical Analysis》2023年第2期127-141,共15页Qili Liao Jie Yang Shengfang Ge Peiwei Chai Jiayan Fan Renbing Jia; the Science and Technology Commission of Shanghai,China(Grant Nos.:20DZ2270800 and 19JC1410200);Innovative Research Team of High-Level Local Universities in Shanghai,China(Grant No.:SHSMU-ZDCX20210900);the National Natural Science Foundation of China(Grant No.:82073889).; The reversible and precise temporal and spatial regulation of histone lysine methyltransferases(KMTs)is essential for epigenome homeostasis.The dysregulation of KMTs is associated with tumor initiation,metastasis,chem...; 关键词：Cancer EPIGENETICS Histone lysine methyltransferase Epigenetic inhibitors Combined therapeutic strategy Clinical application

The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications被引量：1: 《Protein & Cell》2023年第3期165-179,共15页Yanjing Li Kexue Gei Tingting Li Run Cai Yong Chen; supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37010303 to Y.C.);the National Natural Science Foundation of China(31670748,31970576 to Y.C.,and 32071195 and 31900934 to Y.L.);the Young Elite Scientist Sponsorship Program by Chinese Association for Science and Technology(YESS20170198 to Y.L.);the National Postdoctoral Program for Innovative Talents(Bx201700263 to Y.L.).; Histone lysine methyltransferases(HKMTs)deposit methyl groups onto lysine residues on histones and play important roles in regulating chromatin structure and gene expression.The structures and functions of HKMTs have ...; 关键词：NUCLEOSOME cryo-EM structures histone methyltransferases epigenetics histone methylation TUMORIGENESIS

DNA methylation in the genesis,progress and prognosis of head and neck cancer: 《Holistic Integrative Oncology》2023年第1期200-212,共13页Zijian Guo Wenwen Liu Yuhan Yang Shunhao Zhang Chunjie Li Wenbin Yang; supported by the Sichuan University-Panzhihua City 2021 Campus Cooperation Special Fund Project[grant number 2021CDPZH-7].; Epigenetic alteration studies in cancer research have been progressing rapidly in recent years.DNA methylation,including DNA hypermethylation and DNA hypomethylation,is one of the main epigenetic alterations in head a...; 关键词：Head and Neck Cancer(HNC) DNA Methylation DNA(Cytosine-5-)-Methyltransferases(DNMT) Ten-Eleven Translocation(TET) CARCINOGENESIS

Targeting H3K36 methyltransferases NSDs:a promising strategy for tumor targeted therapy: 《Signal Transduction and Targeted Therapy》2021年第7期1933-1934,共2页Xuerun Peng Qian Peng Lei Zhong; This work was supported by the National Natural Science Foundation of China(81702286);the Research Fund of Science&Technology Department of Sichuan Province(2021YJ0134,2018JY0652);the Open Project of Radiation Oncology Key Laboratory of Sichuan Province(2020FSZLX04).; Recently,two studies published in Nature identified genetic changes in the nuclear receptor-binding SET domain protein(NSD)family of histone methyltransferases as oncogenic drivers in some malignancies,and revealed th...; 关键词：METHYLTRANSFERASE TARGETED THERAPY

蛋白质精氨酸甲基转移酶1调控DNA损伤修复和细胞凋亡被引量：2: 《海洋科学》2020年第3期146-152,共7页张一超吴韦韦李奥刘宝华庞秋香; 国家自然科学基金资助项目(31172074,31572263,31701015);山东省自然科学基金资助项目(ZR2017MC066);山东省高等学校科技计划重点项目(J17KZ003)。; 蛋白质精氨酸甲基转移酶1 (protein arginine methyltransferases 1, PRMT1)是PRMT家族中的重要一员,属于Ⅰ型PRMTs,细胞内超过85%的蛋白质精氨酸的甲基化由其催化。PRMT1通过调节底物的甲基化水平,从而调控蛋白的功能及蛋白参与的细胞...; 关键词：PRMT1(protein ARGININE METHYLTRANSFERASES 1) 甲基化 DNA损伤修复细胞凋亡

Histone lysine methyltransferases as anti-cancer targets for drug discovery被引量：3: 《Acta Pharmacologica Sinica》2016年第10期1273-1280,共8页Qing LIU Ming-wei WANG; Acknowledgements We gratefully acknowledge the financial support from the National Health and Family Planning Commission （2012ZX09304-011, 2013ZX09401003-005, 2013ZX09507001, 2013ZX09507-002, and 2014ZX09507002-001）, the National Natural Science Foundation of China （21302202）, Shanghai Science and Technology Development Fund （15DZ2291600）, and the Thousand Talents Program in China.; Post-translational epigenetic modification of histones is controlled by a number of histone-modifying enzymes. Such modification regulates the accessibility of DNA and the subsequent expression or silencing of a gene....; 关键词：histone methyltransferases adenosylmethionine small molecule inhibitors anti-cancer drugs epigenetic modification drugdiscovery

Molecular mechanism for activityregulation of MLL-family methyltransferases: 《Science Foundation in China》2016年第1期16-,共1页; With the support by the National Natural Science Foundation of China,the Chinese Academy of Sciences,the Ministry of Science and Technology of China,and the Basic Research Project of Shanghai Science and Technology Co...; 关键词：Figure conformational unprecedented LEUKEMIA HISTONE CONSERVED biochemical universal HISTONE inherent

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