云南高校图书馆联盟文献共享服务平台- TUMORIGENESIS

TUMORIGENESIS: 作品数：351被引量：2486H指数：21; 导出分析报告; 相关作者：赵相轩卢再鸣满江红路远朱毅更多>>; 相关机构：中国科学院中山大学附属第一医院天津医科大学中国医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>

Insights into targeting LKB1 in tumorigenesis: 《Genes & Diseases》2025年第2期154-170,共17页Charles B.Trelford Trevor G.Shepherd; Genetic alterations to serine-threonine kinase 11(STK11)have been implicated in Peutz-Jeghers syndrome and tumorigenesis.Further exploration of the context-specific roles of liver kinase B1(LKB1;encoded by STK11)obser...; 关键词：AMPK LKB1 Peutz-Jeghers syndrome STK11 Tumor suppressor

GATA6 in pancreatic cancer initiation and progression: 《Genes & Diseases》2025年第2期171-180,共10页Muyuan Ma Jianhong An Tingting Jiang Keping Xie; supported by the Guangzhou Ruiqian Biotech Company (No.20230330 to T.J.);National Natural Science Foundation of China (No.82072632);Guangzhou Municipality Bureau of Science and Technology (China) (No.202102010033 to K.X.);the Natural Science Foundation of Guangdong Province,China (No.2022A1515012585 to K.X.).; t Pancreatic ductal adenocarcinoma(PDA)is a lethal malignancy characterized by insidious onset and lack of effective therapy.The molecular pathogenesis of PDA remains to be understood fully.Transcriptional factor GATA...; 关键词：GATA6 INFLAMMATION Molecular diagnosis PANCREAS Targeted therapy TUMORIGENESIS

KHSRP promotes cancer stem cell maintenance,tumorigenesis,and suppresses anti-tumor immunity in gastric cancer: 《Oncology Research》2025年第2期309-325,共17页YARU DU ZHIHUI PEI SHUQIN HU CHUANWEN LIAO SHUHAO LIU; Supported by the Jiangxi Provincial Health Technology Project(No.202130037 to CWL);was also sponsored by the Jiangxi Provincial Health Technology Project(No.202410009 to SHL)。; Objectives:KH-type splicing regulatory protein(KHSRP)is an RNA-binding protein involved in several cellular processes,including nuclear splicing,mRNA localization,and cytoplasmic degradation.While KHSRP’s role has be...; 关键词：KH-type splicing regulatory protein(KHSRP) Gastric cancer(GC) Cancer stem cell TUMORIGENESIS

Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis被引量：2: 《Genes & Diseases》2025年第1期266-280,共15页Zhenyi Su Yanqing Liu Lin Wang Wei Gu; supported by the National Cancer Institute of the National Institutes of Health(USA)(No.R35CA253059,RO1CA258390,RO1CA254970 to W.G.).; Although cell-cycle arrest,senescence,and apoptosis are well accepted as the classic barriers in tumorigenesis,recent studies indicate that metabolic regulation is equally important as a major checkpoint in cancer dev...; 关键词：Ferroptosis Metabolic checkpoint SLC7A11 Stress Targeted cancer therapy Transcriptional regulation

Perspectives on the potential application of microRNAs in the diagnosis and treatment of triple-negative breast cancer: 《Oncology and Translational Medicine》2025年第1期5-9,共5页Yeqin Wu Haitao Song Huifang Shi Gangping Wang; supported by Shandong Provincial Natural Science Foundation(no.ZR2020MH319).; Triple-negative breast cancer(TNBC)is currently the most heterogeneous and aggressive breast cancer type.It has a high recurrence rate,poor clinical prospects,and lack of predictive markers and potential treatment opt...; 关键词：Triple-negative breast cancer MIRNA oncomiRs TUMORIGENESIS PROGNOSIS Chemotherapy resistance

O-linked β-N-acetylglucosaminylation in lung cancer and beyond: A multidimensional perspective: 《Chinese Medical Journal》2025年第3期355-357,共3页Jinxiu Jiang Xiaochun Huang Jianguo Feng Li Liu Yulin Liu Jing Jia; National Natural Science Foundation of China(No.82000052);Sichuan Science and Technology Program(2022YFS0632);joint foundation of Luzhou Government and Southwest Medical University(Nos.2020LZXNYDJ11,2021LZXNYD-J25);; To the Editor:O-linkedβ-N-acetylglucosaminylation(OGlcNAcylation)is a crucial post-translational modification regulated by two enzymes,O-GlcNAc transferase(OGT)and O-GlcNAcase(OGA).Dysregulation of O-GlcNAcylation ha...; 关键词：lung cancer TUMORIGENESIS OGT post translational modification o linked n acetylglucosaminylation OGA cancer cell adap disease processes

Wnt/GSK-3βmediates posttranslational modifications of FLYWCH1 to regulate intestinal epithelial function and tumorigenesis in the colon: 《Cancer Communications》2025年第1期9-14,共6页Sheema Almozyan Roya Babaei-Jadidi Abrar Aljohani Sepideh Youssefi William Dalleywater Prerna Kadam Bradley Spencer-Dene Emad Rakha Mohammad Ilyas Abdolrahman Shams Nateri; supported by the Medical Research Council(MRC)(grant number G0700763);by the University of Nottingham,Nottingham,UK.; The intestinal epithelium undergoes rapid renewal,with the entire epithelial layer replaced within five days.Intestinal stem cells(ISCs),located in the intestinal crypts,generate all differentiated cell types necessar...; 关键词：TUMORIGENESIS COLON HOMEOSTASIS

Modulation of gut microbiota in targeted cancer therapy:insights on the EGFR/VEGF/KRAS pathways: 《Cancer Biology & Medicine》2024年第12期1141-1155,共15页Li Gong Shixue Yang Junli Huang Yongsheng Li; supported by the Major International(Regional)Joint Research Program of the National Natural Science Foundation of China(Grant No.81920108027);National Outstanding Youth Reserve Talent Training Project,Research Capacity Enhancement Project of Chongqing University Cancer Hospital(Grant No.Y121);Funding for Chongqing Young and Middle-Aged Medical Excellence Team.; The rise in the incidence of cancer globally has led to a heightened interest in targeted therapies as a form of anticancer treatment.Key oncogenic targets,including epidermal growth factor receptor(EGFR),vascular end...; 关键词：Gut microbiota METABOLITES targeted therapy tumorigenesis pathway EGFR VEGF KRAS

The FTO Mediated N6-Methyladenosine Modification of DDIT4 Regulation with Tumorigenesis and Metastasis in Prostate Cancer被引量：1: 《Research》2024年第4期279-298,共20页Yue Zhao Xin Hu Haoran Yu Huimin Sun Lei Zhang Chen Shao; supported by the Natural National Science Foundation of China(No.81972373).; The progression of numerous malignancies has been linked to N6-methyladenosine(m6A)alteration.However,the opposite trend of m6A levels in the development and metastasis of cancer has not been reported.This study aimed...; 关键词：CRISPR/Cas9 METASTASIS INVASION

An overview of the functions and mechanisms of APOBEC3A in tumorigenesis: 《Acta Pharmaceutica Sinica B》2024年第11期4637-4648,共12页Yuqi Yang Nan Liu Likun Gong; Shanghai Post-doctoral Excellence Program(No.2022689,China).; The APOBEC3(A3)family plays a pivotal role in the immune system by performing DNA/RNA single-strand deamination.Cancers mostly arise from the accumulation of chronic mutations in somatic cells,and recent research has ...; 关键词：APOBEC3A DEAMINASE Mutation DNADAMAGE TUMORIGENESIS Tumor-associatedviruses MACROPHAGE Tumormicroenvironment

TUMORIGENESIS