O-linked β-N-acetylglucosaminylation in lung cancer and beyond: A multidimensional perspective  

作　　者：Jinxiu Jiang Xiaochun Huang Jianguo Feng Li Liu Yulin Liu Jing Jia 

机构地区：[1]Department of Anesthesiology,The Affiliated Hospital,Southwest Medical University,Luzhou,Sichuan 646000,China [2]Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou,The Affiliated Hospital,Southwest Medical University,Luzhou,Sichuan 646000,China

出　　处：《Chinese Medical Journal》2025年第3期355-357,共3页中华医学杂志(英文版)

基　　金：National Natural Science Foundation of China(No.82000052);Sichuan Science and Technology Program(2022YFS0632);joint foundation of Luzhou Government and Southwest Medical University(Nos.2020LZXNYDJ11,2021LZXNYD-J25);

摘　　要：To the Editor:O-linkedβ-N-acetylglucosaminylation(OGlcNAcylation)is a crucial post-translational modification regulated by two enzymes,O-GlcNAc transferase(OGT)and O-GlcNAcase(OGA).Dysregulation of O-GlcNAcylation has been implicated in numerous disease processes,particularly in tumorigenesis.Lung cancer is the leading cause of cancer-related mortality worldwide.Most patients with lung cancer are diagnosed at an advanced stage,which poses grave risks to their lives.O-GlcNAcylation facilitates cancer cell adaption to adverse environments,playing a critical role in the onset and progression of lung cancer.This article provides a brief overview of O-GlcNAcylation properties and recent advancements in its study across various diseases,with a particular focus on lung cancer.

关 键 词：lung cancer TUMORIGENESIS OGT post translational modification o linked n acetylglucosaminylation OGA cancer cell adap disease processes 

分 类 号：R734.2[医药卫生—肿瘤]