Perspectives on the potential application of microRNAs in the diagnosis and treatment of triple-negative breast cancer  

作　　者：Yeqin Wu Haitao Song Huifang Shi Gangping Wang 

机构地区：[1]Department of Pathology,the Fourth Affiliated Hospital of Zhejiang University School of Medicine,International School of Medicine Zhejiang University,International Institutes of Medicine Zhejiang University,Yiwu,China [2]Department of Oncology,the Rizhao People’s Hospital,Rizhao,China [3]Central Laboratory,the Rizhao People’s Hospital,Rizhao,China

出　　处：《Oncology and Translational Medicine》2025年第1期5-9,共5页肿瘤学与转化医学(英文版)

基　　金：supported by Shandong Provincial Natural Science Foundation(no.ZR2020MH319).

摘　　要：Triple-negative breast cancer(TNBC)is currently the most heterogeneous and aggressive breast cancer type.It has a high recurrence rate,poor clinical prospects,and lack of predictive markers and potential treatment options.Dysregulated microRNAs(miRNAs)are involved in various cellular processes in TNBC.Moreover,variations in the miRNA levels in TNBC may act as a dependable indicator for predicting the effectiveness and specificity of treatments.Currently,the application of miRNAs for breast cancer therapy is primarily in the preclinical stage,with a focus on identifying highly specific and sensitive miRNAs that could offer new possibilities for early diagnosis,clinical treat-ment,and prognostic monitoring of TNBC.

关 键 词：Triple-negative breast cancer MIRNA oncomiRs TUMORIGENESIS PROGNOSIS Chemotherapy resistance 

分 类 号：R737.9[医药卫生—肿瘤]