DEAMINASE

作品数：57被引量：116H指数：6
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相关领域：医药卫生更多>>
相关作者：姜庆张俊勇邱俊康杭海英胡翠更多>>
相关机构：重庆医科大学附属第二医院中国科学院吉林省计划生育科研所连云港市第一人民医院更多>>
相关期刊：《Computer Modeling in Engineering & Sciences》《Chinese Medical Journal》《Advances in Microbiology》《Agricultural Sciences》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>
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ADATs:roles in tRNA editing and relevance to disease被引量：1
《Acta Biochimica et Biophysica Sinica》2025年第1期73-83,共11页Xue-Ling Mao Gilbert Eriani Xiao-Long Zhou 
supported by the grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0570000);the National Key Research and Development Program of China(Nos.2021YFA1300800 and 2021YFC2700903);the Natural Science Foundation of China(No.32271300);the Committee of Science and Technology in Shanghai(Nos.22ZR1481300 and 22JC1400503);the CAS Project for Young Scientists in Basic Research(No.YSBR-075).
Transfer RNAs(tRNAs)play central roles in protein biosynthesis.Post-transcriptional RNA modifications affect tRNA function and stability.Among these modifications,RNA editing is a widespread RNA modification in three ...
关键词：tRNA editing DEAMINASE TadA ADAT2/3 
An overview of the functions and mechanisms of APOBEC3A in tumorigenesis
《Acta Pharmaceutica Sinica B》2024年第11期4637-4648,共12页Yuqi Yang Nan Liu Likun Gong 
Shanghai Post-doctoral Excellence Program(No.2022689,China).
The APOBEC3(A3)family plays a pivotal role in the immune system by performing DNA/RNA single-strand deamination.Cancers mostly arise from the accumulation of chronic mutations in somatic cells,and recent research has ...
关键词：APOBEC3A DEAMINASE Mutation DNADAMAGE TUMORIGENESIS Tumor-associatedviruses MACROPHAGE Tumormicroenvironment 
Streamlined process for effective and strand-selective mitochondrial base editing using mitoBEs
《Biophysics Reports》2024年第4期191-200,共10页Xiaoxue Zhang Zongyi Yi Wei Tang Wensheng Wei 
supported by funds from the Beijing Municipal Science & Technology Commission (Z181100001318009);the National Science Foundation of China (NSFC31930016);the Beijing Advanced Innovation Center for Genomics at Peking University and the Peking-Tsinghua Center for Life Sciences (to W. Wei);the Fellowship of China Postdoctoral Science Foundation (to Z. Yi)
Mitochondrial base editing tools hold great promise for the investigation and treatment of mitochondrial diseases.Mitochondrial DNA base editors(mitoBEs)integrate a programmable transcriptionactivator-like effector(TA...
关键词：Mitochondrial DNA base editors(mitoBEs) Transcription-activator-like effector(TALE) DEAMINASE Nickase 
Nucleoside deaminases:the key players in base editing toolkit
《Biophysics Reports》2023年第6期325-337,共13页Jiangchao Xiang Wenchao Xu Jing Wu Yaxin Luo Bei Yang Jia Chen 
supported by National Key Research and Development Program National Key R&D Program of China(2023YFC3403400,2018YFA0801401 and 2019YFA0802804);the National Natural Science Foundation of China(32371514 and 32070170);Ministry of Agriculture and Rural Affairs of the People’s Republic of China(NK2022010207);Shanghai Municipal Science and Technology Commission(21JC1404600 and 23ZR1442500);Program of Shanghai Academic/Technology Research Leader(23XD1422500);Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine,Shanghai Tech University
The development of nucleoside deaminase-containing base editors realized targeted single base change with high efficiency and precision.Such nucleoside deaminases include adenosine and cytidine deaminases,which can ca...
关键词：Nucleoside deaminase Base editors 
Programmable deaminase-free base editors for G-to-Y conversion by engineered glycosylase被引量：11
《National Science Review》2023年第8期72-81,共10页Huawei Tong Nana Liu Yinghui Wei Yingsi Zhou Yun Li Danni Wu Ming Jin Shuna Cui Hengbin Li Guoling Li Jingxing Zhou Yuan Yuan Hainan Zhang Linyu Shi Xuan Yao Hui Yang 
This work was supported by HuidaGene Therapeutics Co.,Ltd.(H.T.).
Current DNA base editors contain nuclease and DNA deaminase that enables deamination of cytosine(C)or adenine(A),but no method for guanine(G)or thymine(T)editing is available at present.Here we developed a deaminase-f...
关键词：GLYCOSYLASE base excision repair base editor depurination deaminase-free TRANSVERSION 
Efficient multinucleotide deletions using deaminase-Cas9 fusions in human cells被引量：1
《Journal of Genetics and Genomics》2022年第10期927-933,共7页Siyu Chen Zhiquan Liu Hao Yu Liangxue Lai Zhanjun Li 
supported by the National Key Research and Development Program of China Stem Cell and Translational Research(2019YFA0110700);the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_16R32);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16030501,XDA16030503);Key Research&Development Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory(2018GZR110104004)。
CRISPR/Cas9 system is a robust genome editing platform in biotechnology and medicine.However,it generally produces small insertions/deletions(indels,typically 1-3 bp)but rarely induces larger deletions in specific tar...
关键词：CRISPR/Cas9 DEAMINASE C-DEL A-DEL 
Aromatic disulfides as potential inhibitors against interaction between deaminase APOBEC3G and HIV infectivity factor被引量：1
《Acta Biochimica et Biophysica Sinica》2022年第5期725-735,共11页Xiaoxuan Yan Chao Chen Chunxi Wang Wenxian Lan Jianguo Wang Chunyang Cao 
supported by the grants from the National Natural Science Foundation of China(Nos.21977110,21977057,22174155 and 22177127);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB 20000000);the Center for Excellence in Molecular Synthesis,CAS(No.FZHCZY020600).
APOBEC3G(A3G)is a member of cytosine deaminase family with a variety of innate immune functions.It displays activities against retrovirus and retrotransposon by inhibition of virus infectivity factor(Vif)-deficient HI...
关键词：APOBEC3G VIF INTERACTION HIV-1 aromatic disulfide 
Ultraviolet B radiation-mediated stress ethylene emission from rice plants is regulated by 1-aminocyclopropane-1-carboxylate deaminase-producing bacteria被引量：1
《Pedosphere》2022年第2期364-368,共5页Jeongyun CHOI Aritra ROY CHOUDHURY Myung-Min OH Denver I.WALITANG Tongmin SA 
supported by the Basic Research Program through the National Research Foundation (NRF) funded by the Ministry of Education, Science and Technology, Republic of Korea (No. 2021R1A2C1006608)。
Dear Editor,Industrial emissions have played a major role in damaging the ozone layer,leading to increased atmospheric penetration of ultraviolet B (UV-B)(290–320 nm) radiation (Jordan,2002).The recovery rate of the ...
关键词：CROPS ozone LATITUDE 
Seed priming with Pseudomonas putida isolated from rhizosphere triggers innate resistance against Fusarium wilt in tomato through pathogenesis-related protein activation and phenylpropanoid pathway被引量：1
《Pedosphere》2020年第5期651-660,共10页Nellickal Subramanyan JAYAMOHAN Savita Veeranagouda PATIL Belur Satyan KUMUDINI 
The authors are thankful to JAIN(Deemed-to-be University),India and Department of Science and Technology-Science and Engineering Research Board(DST-SERB),India(No.YSS/2015/001905)for the financial and infrastructural supports.
Pathogenesis-related(PR)proteins are one of the major and preliminary proteins accumulated as a defense against biotic stress.This defense response can be induced by using beneficial rhizobacteria,which has been studi...
关键词：1-aminocyclopropane-l-carboxylic acid(ACC)deaminase biocontrol agent disease incidence mycolytic enzymes host-specific pathogen rhizosphere competence 
Enhancement of α-ketoisovalerate production by relieving the product inhibition of L-amino acid deaminase from Proteus mirabilis被引量：2
《Chinese Journal of Chemical Engineering》2020年第8期2190-2199,共10页Shanshan Pei Xiaobo Ruan Jia Liu Wei Song Xiulai Chen Qiuling Luo Liming Liu Jing Wu 
financially supported by the national first-class discipline program of Light Industry Technology and Engineering(LITE201820);the Key Technologies Research and Development Program of Jiangsu Province(BE2018623)。
L-Amino acid deaminase(LAAD) is a key enzyme in the deamination of L-valine(L-val) to produce α-ketoisovalerate(KIV). However, the product inhibition of LAAD is a major hindrance to industrial KIV production.In the p...
关键词：Product inhibition L-Amino acid deaminases α-Ketoisovalerate Bio-catalysis Protein engineering 
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