GLYCOSYLASE

作品数：9被引量：72H指数：4
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相关领域：医药卫生生物学更多>>
相关作者：林小伟刘红梅李家璜孙凤艳华子春更多>>
相关机构：复旦大学上海医学院复旦大学南京大学更多>>
相关期刊：《Science Bulletin》《Neuroscience Bulletin》《National Science Review》《Engineering Microbiology》更多>>
相关基金：国家自然科学基金更多>>
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A novel strategy to protect prokaryotic cells from virus infection
《Engineering Microbiology》2024年第2期104-106,共3页Yoshizumi Ishino 
The recent discovery of the CRISPR-Cas-mediated acquired immunity system highlights the fact that our knowl-edge of phage/virus defense mechanisms encoded in bacterial and archaeal genomes is far from complete.Indeed,...
关键词：Prokaryotic immunity Antiviral defense GLYCOSYLASE Modified base Functional screening 
Programmable deaminase-free base editors for G-to-Y conversion by engineered glycosylase被引量：11
《National Science Review》2023年第8期72-81,共10页Huawei Tong Nana Liu Yinghui Wei Yingsi Zhou Yun Li Danni Wu Ming Jin Shuna Cui Hengbin Li Guoling Li Jingxing Zhou Yuan Yuan Hainan Zhang Linyu Shi Xuan Yao Hui Yang 
This work was supported by HuidaGene Therapeutics Co.,Ltd.(H.T.).
Current DNA base editors contain nuclease and DNA deaminase that enables deamination of cytosine(C)or adenine(A),but no method for guanine(G)or thymine(T)editing is available at present.Here we developed a deaminase-f...
关键词：GLYCOSYLASE base excision repair base editor depurination deaminase-free TRANSVERSION 
Genetic and environmental determinants of risk for cholangiocarcinoma in Thailand被引量：1
《World Journal of Gastrointestinal Pathophysiology》2014年第4期570-578,共9页Masanao Miwa Satoshi Honjo Gyokukou You Masakazu Tanaka Kazuhiko Uchida Petcharin Srivatanakul Thiravud Khuhaprema Watcharin Loilome Anchalee Techasen Chaisiri Wongkham Temduang Limpaiboon Puangrat Yongvanit Sopit Wongkham 
Supported by Grant-in-Aid for Scientific Research from the Ministry of Education,Culture,Sports,Science and Technology Japan
Cholangiocarcinoma(CCA) is a difficult cancer to diagnose in the early stage and to treat by curative resec-tion. The incidence of CCA in the northeast of Thailand is the highest in the world. To make progress in dete...
关键词：Alcohol drinking CHOLANGIOCARCINOMA DNA polymorphism GLUTATHIONE S TRANSFERASE 8-oxoguanine GLYCOSYLASE 1 Liver FLUKE OPISTHORCHIS viverrini Thailand 
Oxidative stress and male reproductive health被引量：50
《Asian Journal of Andrology》2014年第1期31-38,共8页Robert J Aitken Tegan B Smith Matthew S Jobling Mark A Baker Geoffry N De Iuliis 
One of the major causes of defective sperm function is oxidative stress, which not only disrupts the integrity of sperm DNA but also limits the fertilizing potential of these cells as a result of collateral damage to ...
关键词：DNA damage oxidative stress oxoguanine glycosylase 1 OOCYTE SPERMATOZOA 
Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis被引量：1
《World Journal of Gastroenterology》2013年第48期9366-9376,共11页Marnie J Wood Lawrie W Powell Jeannette L Dixon V Nathan Subramaniam Grant A Ramm 
Supported by NHMRC Medical Postgraduate Scholarship and the Royal Brisbane and Women’s Hospital Research Foundation to Wood MJ;the National Health and Medical Research Council(NHMRC)to Ramm GA and Powell LW;the recipient of an NHMRC Senior Research Fellowship,1024672 to Subramaniam VN;an NHMRC Senior Research Fellowship,No.552409 to Ramm GA
AIM:To investigate the role of genetic polymorphisms in the progression of hepatic fibrosis in hereditary haemochromatosis.METHODS:A cohort of 245 well-characterised C282Y homozygous patients with haemochromatosis was...
关键词：HAEMOCHROMATOSIS Genetic polymorphism Liver FIBROSIS TOLL-LIKE receptor 4 Interleukin 10 Monocyte CHEMOATTRACTANT protein 1 Chemokine(C-C motif) ligand 2 Transforming growth factor beta 8-oxoguanine DNA GLYCOSYLASE 
HOGG1 polymorphism in atrophic gastritis and gastric cancer after Helicobacter pylori eradication被引量：4
《World Journal of Gastroenterology》2010年第35期4476-4482,共7页Lei-Min Sun  Yan Shang  Ya-Min Zeng  Yan-Yong Deng  Jian-Feng Cheng 
Supported by The grants from the Education Department of Zhejiang Province, China, No Y200803495;Zhejiang Provincial Administration of Traditional Chinese Medicine, China, No 2008CA058;Qianjiang Talent Project of Science and Technology, China, No 2008R10022
AIM:To investigate the association between Ser326Cys human oxoguanine glycosylase 1(hOGG1) polymorphism and atrophic gastritis and gastric cancer after Helicobacter pylori(H.pylori) eradication.METHODS:A total of 488 ...
关键词：Human oxoguanine glycosylase 1 polymorphism Atrophic gastritis Gastric cancer 
1-Methyl-4-phenyl-pyridinium time-dependently alters expressions of oxoguanine glycosylase 1 and xeroderma pigmentosum group F protein in PC12 cells
《Neuroscience Bulletin》2010年第1期1-7,共7页刘红梅 杨善争 孙凤艳 
supported by the National Natural Science Foundation of China (No. 30770660,J0730860)
Objective To determine if DNA excision repair enzymes oxoguanine glycosylase 1 （OGG1） and xeroderma pigmentosum group F protein （XPF） are involved in the pathogenesis of Parkinson＇s disease （PD） in a cell model...
关键词：1-Methyl-4-phenyl-pyridinium oxoguanine glycosylase 1 xeroderma pigmentosum group F protein PC12 cells 
Structure and mechanism for DNA lesion recognition被引量：5
《Cell Research》2008年第1期184-197,共14页Wei Yang 
A fundamental question in DNA repair is how a lesion is detected when embedded in millions to billions of normal base pairs. Extensive structural and functional studies reveal atomic details of DNA repair protein and ...
关键词：base unstacking MMR BER NER ATPASE NUCLEASE GLYCOSYLASE 
Fragile X mental retardation protein interacts with TDG
《Chinese Science Bulletin》2000年第6期516-520,共5页Bardoni B MandelJ.-L 
Fragiie X syndrome is the most common form of inherited mental retardation disease, resulting from absent of expression of its disease gene FMR1. To study the function of the fragiie X mental retardation protein (FMRP...
关键词：fragile X mental RETARDATION protein G/T mismatch-specific DNA THYMINE GLYCOSYLASE yeast TWO-HYBRID protein/protein interaction. 
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