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作品数：122被引量：333H指数：9
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相关作者：郭书娟陶生策邓瑞萍孙国杰杜艳军更多>>
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O-linked β-N-acetylglucosamine transferase regulates macrophage polarization in diabetic periodontitis: In vivo and in vitro study
《World Journal of Diabetes》2025年第3期167-186,共20页Ye-Ke Wu Min Liu Hong-Ling Zhou Xiang He Jing Wei Wei-Han Hua Hui-Jing Li Qiang-Hua Yuan Yun-Fei Xie 
Supported by the National Natural Science Foundation of China,No.81973684;Natural Science Foundation of Sichuan Province,No.2023NSFSC1760;Youth Talent Fund of Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital,No.2021QN09。
BACKGROUND Periodontitis,when exacerbated by diabetes,is characterized by increased M1 macrophage polarization and decreased M2 polarization.O-linkedβ-N-acetylglucosamine(O-GlcNAcylation),catalyzed by O-GlcNAc transf...
关键词：Diabetic periodontitis Macrophage polarization O-linkedβ-N-acetylglucosamine O-linkedβ-N-acetylglucosamine transferase P38 
The phosphoethanolamine transferase PetL of Pasteurella multocida is associated with colistin resistance
《Animal Diseases》2025年第1期33-42,共10页Jie Yang Lin Lin Haixin Bi Congcong Shi Qingjie Lv Lin Hua Huanchun Chen Bin Wu Zhong Peng 
supported in part by the Hubei Provincial Natural Science Foundation of China(grant no.2023AFA094);the Yingzi Tech&Huazhong Agricultural University Intelligent Research Institute of Food Health(No.IRIFH202209);Fundamental Research Funds for the Central Universities(Project 2662023PY005);the Hubei Hongshan Laboratory&Huazhong Agricultural University Start-up Fund.
The rapid emergence and spread of colistin-resistant gram-negative bacteria has raised worldwide public health concerns,and phosphoethanolamine(PEtn)transferase modification-mediated colistin resistance has been widel...
关键词：Antimicrobial resistance COLISTIN Pasteurella multocida Phosphoethanolamine transferase Lipid A 
Carnitine palmitoyltransferase-II inactivity promotes malignant progression of metabolic dysfunction-associated fatty liver disease via liver cancer stem cell activation
《World Journal of Gastroenterology》2024年第47期5055-5069,共15页Ling-Ling Wang Yu-Ming Lu Yi-Han Wang Yi-Fan Wang Rong-Fei Fang Wen-Li Sai Deng-Fu Yao Min Yao 
Supported by the National Natural Science Foundation of China,No.32470985 and No.81673241.
BACKGROUND Metabolic dysfunction-associated fatty liver disease(MAFLD)is one of the main chronic liver diseases.However,the roles of mitochondrial carnitine palmitoyl transferase-II(CPT-II)downregulation and liver can...
关键词：Metabolic dysfunction-associated fatty liver disease Carnitine palmitoyl transferase-II Mitochondria T lymphocytes Liver cancer stem cells 
Nomogram model based on γ-glutamyl transferase to albumin ratio predicts survival in hepatocellular carcinoma patients with transarterial chemoembolization treatment
《World Journal of Gastrointestinal Oncology》2024年第12期4650-4662,共13页Zhen-Ying Wu Han Li Jia-Li Chen Ke Su Mei-Ling Weng Yun-Wei Han 
BACKGROUND The development of tumor is closely linked to inflammation.Therefore,targeting molecules involved in inflammation may be effective in predicting cancer prognosis.Transarterial chemoembolization(TACE)holds s...
关键词：Transarterial chemoembolization IMMUNOTHERAPY Targeted therapy Hepatocellular carcinoma Prognosis 
Rethinking neurodegenerative diseases:neurometabolic concept linking lipid oxidation to diseases in the central nervous system被引量：2
《Neural Regeneration Research》2024年第7期1437-1445,共9页Steinunn Sara Helgudóttir Anne Skøttrup Mørkholt Jacek Lichota Preben Bruun-Nyzell Mads Christian Andersen Nanna Marie Juhl Kristensen Amanda Krøger Johansen Mikela Reinholdt Zinn Hulda Maria Jensdóttir John Dirk Vestergaard Nieland 
Currently,there is a lack of effective medicines capable of halting or reve rsing the progression of neurodegenerative disorde rs,including amyotrophic lateral sclerosis,Parkinson s disease,multiple sclerosis,or Alzhe...
关键词：brain disease carnitine palmitoyl transferase 1 EPIGENETICS metabolism gut microbiome mitochondrial dysfunction NEURODEGENERATION oxidative stress 
Targeting carnitine palmitoyl transferase 1A(CPT1A)induces ferroptosis and synergizes with immunotherapy in lung cancer被引量：4
《Signal Transduction and Targeted Therapy》2024年第4期1675-1689,共15页Lei Ma Chong Chen Chunxing Zhao Tong Li Lingyu Ma Jiayu Jiang Zhaojun Duan Qin Si Tsung-Hsien Chuang Rong Xiang Yunping Luo 
supported by grants from the National Natural Science Foundation of China (NSFC):grant no.82373100 (to C.C.),81972795 (to C.C.)and 82273220 (to Y.L.);the Bilateral Inter-Governmental S&T Cooperation Project from Ministry of Science and Technology of China:grant no.2018YFE0114300 (to R.X.and Y.L);the Fundamental Research Funds for the Central Universities:grant no.3332022140 (to L.M.).
Despite the successful application of immune checkpoint therapy,no response or recurrence is typical in lung cancer.Cancer stem cells(CSCs)have been identified as a crucial player in immunotherapy-related resistance.F...
关键词：IMMUNOTHERAPY METABOLISM PEROXIDATION 
Case Report: Carnitine Palmitoyl Transferase II (CPT II) Deficiency
《Open Journal of Internal Medicine》2024年第1期93-101,共9页Kathy Po Marius Chivu Edwin Rosas Balpreet Kaur 
Carnitine Palmitoyl Transferase II (CPTII) is a very important enzyme that helps with the oxidation of long-chain fatty acid to produce energy. Deficiency in CPTII will lead to energy deficiency in the case of fasting...
关键词：Carnitine Palmitoyl Transferase II (CPTII) Mitochondria Long Chain Fatty Acid Medium Chain Fatty Acid CARNITINE Carnitine Palmitoyl Transferase I (CPTI) Acyl-Carnitine BETA-OXIDATION RHABDOMYOLYSIS Myoglobinuria Renal Failure Hypoketotic Hypoglycemia 
Xiaotan Sanjie recipe,a compound Chinese herbal medicine,inhibits gastric cancer metastasis by regulating GnT-V-mediated E-cadherin glycosylation
《Journal of Integrative Medicine》2023年第6期561-574,共14页Nian Huang Hai-wei He Yu-yu He Wei Gu Ming-juan Xu Long Liu 
supported by Scientific Research Fund of Young Teachers in Naval Medical University(No.2022QN093).
Objective:Xiaotan Sanjie recipe(XTSJ),a Chinese herbal compound medicine,exerts a significant inhibitory effect on gastric cancer(GC)metastasis.This work investigated the mechanism underlying the XTSJmediated inhibiti...
关键词：Xiaotan Sanjie Recipe Gastric cancer Traditional Chinese medicine E-CADHERIN Metastasis Glc-N-Ac-transferase V 
Is bitter actually better?Targeting a soyasaponin acetyltransferase affects soybean seed germination
《Journal of Integrative Plant Biology》2023年第11期2409-2411,共3页Yongshuo Ma Yi Shang 
Soyasaponins are a class of triterpenoid saponins that accumulate in soybean(Glycine max)seeds and give a bitter flavor to some soybean products(Berhow et al.,2006).Acetylated sugars at C22 in type-A soyasaponins are ...
关键词：SAPONINS sugar soybean 
Evaluation of trabecular meshwork-specific promoters in vitro and in vivo using scAAV2 vectors expressing C3 transferase被引量：2
《International Journal of Ophthalmology(English edition)》2023年第8期1196-1209,共14页Jun-Kai Tan Ying Xiao Guo Liu Long-Xiang Huang Wen-Hao Ma Yan Xia Xi-Zhen Wang Xian-Jun Zhu Su-Ping Cai Xiao-Bing Wu Yun Wang Xu-Yang Liu 
Supported by the National Natural Science Foundation of China(No.81900829,No.82070963);the Xiamen Medical and Health Guiding Project Fund Project(No.3502Z20214ZD1214);the Guangdong Basic and Applied Basic Research Foundation(No.2019A1515011234);the Science and Technology Innovation Committee of Shenzhen(No.JCYJ20210324125614039)。
AIM:To evaluate the potential of two trabecular meshwork(TM)-specific promoters,Chitinase 3-like 1(Ch3L1)and matrix gla protein(MGP),for improving specificity and safety in glaucoma gene therapy based on self-compleme...
关键词：self-complementary AAV2 chitinase 3-like 1 matrix gla protein trabecular meshwork C3 transferase 
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