CARNITINE

作品数：52被引量：133H指数：6
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相关作者：刘嫣然包蕾李梦琪梅玫鲍时来更多>>
相关机构：重庆医科大学北海道药科大学广州医科大学西南大学更多>>
相关期刊：《Journal of Animal Science and Biotechnology》《Journal of Diabetes Mellitus》《Acta Pharmacologica Sinica》《生理科学进展》更多>>
相关基金：国家自然科学基金广西壮族自治区自然科学基金国家重点基础研究发展计划更多>>
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Carnitine palmitoyltransferase-II inactivity promotes malignant progression of metabolic dysfunction-associated fatty liver disease via liver cancer stem cell activation
《World Journal of Gastroenterology》2024年第47期5055-5069,共15页Ling-Ling Wang Yu-Ming Lu Yi-Han Wang Yi-Fan Wang Rong-Fei Fang Wen-Li Sai Deng-Fu Yao Min Yao 
Supported by the National Natural Science Foundation of China,No.32470985 and No.81673241.
BACKGROUND Metabolic dysfunction-associated fatty liver disease(MAFLD)is one of the main chronic liver diseases.However,the roles of mitochondrial carnitine palmitoyl transferase-II(CPT-II)downregulation and liver can...
关键词：Metabolic dysfunction-associated fatty liver disease Carnitine palmitoyl transferase-II Mitochondria T lymphocytes Liver cancer stem cells 
Carnitine is causally associated with susceptibility and severity of sepsis: a Mendelian randomization study
《Emergency and Critical Care Medicine》2024年第4期149-154,共6页Qingju Zhang Xilong Liu Qi Shen Xingfang Wang Jiaojiao Pang Yuguo Chen 
This study was supported by the State Key Program of the National Natural Science Foundation of China(82030059);National Natural Science Foundation of China(82172127,81772036,82072144,81671952,81873950,and 81873953);National Key R&D Program of China(2020YFC1512700,2020YFC1512705,2020YFC1512703,and 2020YFC0846600);National S&T Fundamental Resources Investigation Project(2018FY100600,2018FY100602);Taishan Pandeng Scholar Program of Shandong Province(tspd20181220);Taishan Young Scholar Program of Shandong Province(tsqn20161065,tsqn201812129);Youth Top-Talent Project of National Ten Thousand Talents Plan,Qilu Young Scholar Program,and the Fun-damental Research Funds of Shandong University(2018JC011).
Background:Energy metabolism disorders contribute to the development of sepsis.Carnitine is essential for fatty acid metabolism and energy production.Therefore,we aimed to explore whether there is a causal relationshi...
关键词：CARNITINE CAUSALITY Genome-wide association study(GWAS) Mendelian randomization SEPSIS 
Analytical Method Development and Validation of Content of D-Carnitine in Levocarnitine Using High-Performance Liquid Chromatography
《American Journal of Analytical Chemistry》2024年第12期407-426,共20页M. Narasimha Naidu Kannan Jakkan P. Sanjeeva P. Venkata Ramana 
A novel HPLC method was developed and validated for the determination of D-Carnitine in Levocarnitine in accordance with the ICH Q2R1 guidelines. The method demonstrated system precision, specificity, precision at the...
关键词：CARNITINE D-Carnitine Levocarnitine HPLC 
Methylmalonic Acidemia: An Unusual Cause of Chronic Renal Disease in Adults
《Open Journal of Nephrology》2024年第3期334-339,共6页Kamel El Reshaid Abdulrahman Al Kanderi 
Background: Methylmalonic aciduria (MMA) is a genetic disorder of aminoacid metabolism, due to mutations in methylmalonyl-CoA mutase, which leads to the accumulation of methylmalonic acid in body fluids. Patients typi...
关键词：Methylmalonic Acidemia Kidney Failure Metabolic Acidosis Autosomal Recessive Amino Acid Disorder Kreps Cycle Hyperammonia Vitamin 12 CARNITINE 
Rethinking neurodegenerative diseases:neurometabolic concept linking lipid oxidation to diseases in the central nervous system被引量：2
《Neural Regeneration Research》2024年第7期1437-1445,共9页Steinunn Sara Helgudóttir Anne Skøttrup Mørkholt Jacek Lichota Preben Bruun-Nyzell Mads Christian Andersen Nanna Marie Juhl Kristensen Amanda Krøger Johansen Mikela Reinholdt Zinn Hulda Maria Jensdóttir John Dirk Vestergaard Nieland 
Currently,there is a lack of effective medicines capable of halting or reve rsing the progression of neurodegenerative disorde rs,including amyotrophic lateral sclerosis,Parkinson s disease,multiple sclerosis,or Alzhe...
关键词：brain disease carnitine palmitoyl transferase 1 EPIGENETICS metabolism gut microbiome mitochondrial dysfunction NEURODEGENERATION oxidative stress 
Targeting carnitine palmitoyl transferase 1A(CPT1A)induces ferroptosis and synergizes with immunotherapy in lung cancer被引量：4
《Signal Transduction and Targeted Therapy》2024年第4期1675-1689,共15页Lei Ma Chong Chen Chunxing Zhao Tong Li Lingyu Ma Jiayu Jiang Zhaojun Duan Qin Si Tsung-Hsien Chuang Rong Xiang Yunping Luo 
supported by grants from the National Natural Science Foundation of China (NSFC):grant no.82373100 (to C.C.),81972795 (to C.C.)and 82273220 (to Y.L.);the Bilateral Inter-Governmental S&T Cooperation Project from Ministry of Science and Technology of China:grant no.2018YFE0114300 (to R.X.and Y.L);the Fundamental Research Funds for the Central Universities:grant no.3332022140 (to L.M.).
Despite the successful application of immune checkpoint therapy,no response or recurrence is typical in lung cancer.Cancer stem cells(CSCs)have been identified as a crucial player in immunotherapy-related resistance.F...
关键词：IMMUNOTHERAPY METABOLISM PEROXIDATION 
Case Report: Carnitine Palmitoyl Transferase II (CPT II) Deficiency
《Open Journal of Internal Medicine》2024年第1期93-101,共9页Kathy Po Marius Chivu Edwin Rosas Balpreet Kaur 
Carnitine Palmitoyl Transferase II (CPTII) is a very important enzyme that helps with the oxidation of long-chain fatty acid to produce energy. Deficiency in CPTII will lead to energy deficiency in the case of fasting...
关键词：Carnitine Palmitoyl Transferase II (CPTII) Mitochondria Long Chain Fatty Acid Medium Chain Fatty Acid CARNITINE Carnitine Palmitoyl Transferase I (CPTI) Acyl-Carnitine BETA-OXIDATION RHABDOMYOLYSIS Myoglobinuria Renal Failure Hypoketotic Hypoglycemia 
Establishment of a metabolite diagnostic model for the risk of diabetic nephropathy in type 2 diabetic population:Based on a cross-sectional study in China
《EngMedicine》2024年第2期31-36,共6页Jing-Yang Su Yong-Jie Chen Wei Zhang Rui Zhang Tong-Feng Liu Wei-Ming Luo Xi-Lin Yang Zhong-Ze Fang 
Funding for this project was provided by the Project for the National Key Research and Development Program of China(2021YFA1301202);the National Natural Science Foundation of China(82273676);the Liaoning Province Scientific and Technological Project(2021JH2/10300039).
Introduction:This study aimed to investigate the correlation between various plasma metabolites and the likelihood of developing diabetic nephropathy(DN)and construct a diagnostic model for DN in Chinese patients with...
关键词：Diabetes mellitus Diabetic nephropathy Diagnostic model Amino acids CARNITINE 
Obese Ningxiang pig-derived microbiota rewires carnitine metabolism to promote muscle fatty acid deposition in lean DLY pigs被引量：2
《The Innovation》2023年第5期69-77,共9页Jie Yin Yunxia Li Yu Tian Feng Zhou Jie Ma Siting Xia Tong Yang Libao Ma Qinghua Zeng Gang Liu Yulong Yin Xingguo Huang 
National Natural Science Foundation of China(U20A2055 and 32172761);National Key Research and Development Program of China(2022YFD1301500);Hunan Youth Science and Technology Talent Project(2022RC1157).
The gut microbiota consistently shows strong correlations with lipid metabolism in humans and animals,and whether the gut microbiota contributes to muscle fatty acid(FA)deposition and meat traits in farm animals has n...
关键词：DLY Ningxia fir 
Mitochondrial carnitine palmitoyltransferase-Ⅱ dysfunction: A possible novel mechanism for nonalcoholic fatty liver disease in hepatocarcinogenesis
《World Journal of Gastroenterology》2023年第12期1765-1778,共14页Min Yao Ping Zhou Yan-Yan Qin Li Wang Deng-Fu Yao 
Supported by the National Natural Science Foundation of China,No.81873915 and No.31872738;the Key Plan of Nantong S&T Development,No.MS12020021;the S&T Program of Medical School of Nantong University,No.TDYX2021010.
Nonalcoholic fatty liver disease(NAFLD)or metabolic-associated fatty liver disease has been characterized by the lipid accumulation with injury of hepatocytes and has become one of the most common chronic liver diseas...
关键词：Carnitine palmitoyl transferase-II Nonalcoholic fatty liver disease Fatty acidβ-oxidation CARNITINE Hepatocyte malignant transformation Mitochondrial membrane 
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