Mitochondrial carnitine palmitoyltransferase-Ⅱ dysfunction: A possible novel mechanism for nonalcoholic fatty liver disease in hepatocarcinogenesis  

作　　者：Min Yao Ping Zhou Yan-Yan Qin Li Wang Deng-Fu Yao 

机构地区：[1]Department of Medical Immunology,Medical School of Nantong University&Research Center of Clinical Medicine,Affiliated Hospital of Nantong University,Nantong 226001,Jiangsu Province,China [2]Department of Medical Immunology,Medical School of Nantong University,Nantong 226001,Jiangsu Province,China [3]Research Center for Intelligent Information Technology,Nantong University,Nantong 226019,Jiangsu Province,China [4]Research Center of Clinical Medicine,Affiliated Hospital of Nantong University,Nantong 226001,Jiangsu Province,China

出　　处：《World Journal of Gastroenterology》2023年第12期1765-1778,共14页世界胃肠病学杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China,No.81873915 and No.31872738;the Key Plan of Nantong S&T Development,No.MS12020021;the S&T Program of Medical School of Nantong University,No.TDYX2021010.

摘　　要：Nonalcoholic fatty liver disease(NAFLD)or metabolic-associated fatty liver disease has been characterized by the lipid accumulation with injury of hepatocytes and has become one of the most common chronic liver diseases in the world.The complex mechanisms of NAFLD formation are still under identification.Carnitine palmitoyltransferase-Ⅱ(CPT-Ⅱ)on inner mitochondrial membrane(IMM)regulates long chain fatty acidβ-oxidation,and its abnormality has had more and more attention paid to it by basic and clinical research in NAFLD.The sequences of its peptide chain and DNA nucleotides have been identified,and the catalytic activity of CPT-Ⅱ is affected on its gene mutations,deficiency,enzymatic thermal instability,circulating carnitine level and so on.Recently,the CPT-Ⅱ dysfunction has been discovered in models of liver lipid accumulation.Meanwhile,the malignant transformation of hepatocyte-related CD44^(+) stem T cell activation,high levels of tumor-related biomarkers(AFP,GPC3)and abnormal activation of Wnt3a expression as a key signal molecule of the Wnt/β-catenin pathway run parallel to the alterations of hepatocyte pathology.This review focuses on some of the progress of CPT-Ⅱ inactivity on IMM with liver fatty accumulation as a possible novel pathogenesis for NAFLD in hepatocarcinogenesis.

关 键 词：Carnitine palmitoyl transferase-II Nonalcoholic fatty liver disease Fatty acidβ-oxidation CARNITINE Hepatocyte malignant transformation Mitochondrial membrane 

分 类 号：R575.5[医药卫生—消化系统] R735.7[医药卫生—内科学]