SEPSIS

作品数：960被引量：3986H指数：25
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相关机构：中国人民解放军总医院首都医科大学附属北京儿童医院北京协和医院重庆医科大学更多>>
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Analysis of risk factors and predictive value of a nomogram model for sepsis in patients with diabetic foot
《World Journal of Diabetes》2025年第4期144-152,共9页Wen-Wen Han Jian-Jiang Fang 
BACKGROUND Sepsis is a severe complication in hospitalized patients with diabetic foot(DF),often associated with high morbidity and mortality.Despite its clinical significance,limited tools exist for early risk predic...
关键词：Diabetic foot SEPSIS Risk factors NOMOGRAM Prediction model 
The role of early changes in routine coagulation tests in predicting the occurrence and prognosis of sepsis
《World Journal of Emergency Medicine》2025年第2期136-143,共8页Peili Chen Yan Ge Huiqiu Sheng Wenwu Sun Jiahui Wang Li Ma Enqiang Mao 
supported by the Science and Technology Commission of Shanghai Municipality (grant no.22Y11900300);China Primary Health Care Foundation (grant no.MTP2022A0132);Project of Shanghai Administration of Traditional Chinese Medicine (ZXXT-202213)to EQM and LM。
BACKGROUND:This study aimed to explore the importance of routine coagulation tests for the early detection of sepsis and to quickly identify patients at a high risk of mortality.METHODS:This retrospective single-cente...
关键词：SEPSIS COAGULATION ABNORMALITIES FIBRINOLYSIS Biomarker 
Circulating circular RNAs act as potential novel biomarkers for sepsis secondary to pneumonia:a prospective cohort study
《World Journal of Emergency Medicine》2025年第2期144-152,共9页Chunxue Wang Dianyin Yang Yuxin Zhu Qian Yang Tong Liu Xiandong Liu Dongyang Zhao Xiaowei Bao Tiancao Dong Li Shao Lunxian Tang 
supported by grants from the municipal Natural Science Foundation of Shanghai Scientific Committee of China(22ZR1451000 to TL);the peak supporting clinical discipline of Shanghai Health Bureau(2023ZDFC0104 to TL);the key clinical discipline of Shanghai Pudong Health Bureau(PWZxk2022-17 to TL);the clinical peak discipline of Shanghai Pudong Heath Bureau(PWYgf2021-03);the top-notch innovative medical talents of Shanghai Pudong Health Bureau(2025PDWSYCBJ-03 to TL);the leading medical talent project of Shanghai Pudong Heath Bureau(PWR12020-07 to LS)。
BACKGROUND:Circulating biomarkers for sepsis are lacking,and research on circular RNAs(circR NAs)as potential biomarkers of pneumonia-induced sepsis is limited.This study aims to investigate the diagnostic and prognos...
关键词：Circular RNAs BIOMARKER Pneumonia-induced sepsis Diagnosis Prognosis 
Exosomal mediators in sepsis and inflammatory organ injury:unraveling the role of exosomes in intercellular crosstalk and organ dysfunction
《Military Medical Research》2025年第2期264-284,共21页Ting Gong You-Tan Liu Jie Fan 
USA National Institutes of Health Grant(R01-HL-139547,to JF);USA VA Grants(1I01BX004838 and IK6BX004211,to JF);National Natural Science Foundation of China(82002087,to TG);Shenzhen Science and Technology Program(JCYJ20210324134602008,to TG)。
Sepsis,a severe systemic inflammatory response to infection,remains a leading cause of morbidity and mortality worldwide.Exosomes,as mediators of intercellular communication,play a pivotal role in the pathogenesis of ...
关键词：SEPSIS EXOSOMES Intercellular crosstalk Inflammation Biomarkers 
Aloin ameliorates cecal ligation and puncture-induced sepsis in mice by attenuating inflammation and modulating gut microbiota
《Food Science and Human Wellness》2025年第2期550-568,共19页Jingqian Su Jianbin Xiao Siyuan Chen Heng Zhao Xiaoni Zhang Zhihua Feng Kunsen Chen Biyun Guan Wenzhi Chen Youqiang Chen Duo Chen Qi Chen 
supported by the National Natural Science Foundation of China(81803547);the Natural Science Foundation of Fujian Province,China(2021J01204);Fujian Provincial Regional Development Project(2021N3005)。
Most Aloe species are used as new food or functional food ingredient.Even though widely known for its health benefits,the anti-inflammatory effects and underlying mechanisms of Aloin(Alo),an anthraquinone compound iso...
关键词：ALOIN Gut microbiome SEPSIS INFLAMMATION Cecal ligation and puncture 
Study of the relationship between iron metabolism disorders and sepsis-associated liver injury:A prospective observational study
《World Journal of Gastroenterology》2025年第14期71-82,共12页Tian-Wei Wang Lu-Lu Zhou Jing Yuan Wen-Xin Zhou Hao-Ran Wang Ting-Ting Yu Ji-Chao Zhai Cheng-Bin Tang Wei Jiang Jiang-Quan Yu Rui-Qiang Zheng Hai-Long Yu Jun Shao 
Supported by the National Science Foundation of Jiangsu Province,No.BK20221280;the National Natural Science Foundation of China,No.82371336;the Chinese Postdoctoral Science Foundation,No.2022M711426;the Special Fund for Social Key Research and Development Plan of Yangzhou City,No.YZ2022097;Yangzhou Municipal Science and Technology Bureau,No.YZ2024091 and No.YZ2022098.
BACKGROUND Sepsis-associated liver injury(SALI)refers to secondary liver function impairment caused by sepsis,patients with SALI often have worse clinical outcomes.The early identification and assessment of the occurr...
关键词：SEPSIS Liver injury Iron metabolism Biomarkers Serum iron Total iron-binding capacity 
Nicotinamide mononucleotide protects septic hearts in mice via preventing cyclophilin F modification and lysosomal dysfunction
《Acta Pharmacologica Sinica》2025年第4期976-988,共13页Rui Ni Xiao-yun Ji Ting Cao Xiu-wen Liu Chao Wang Chao Lu Angel Peng Zhu-xu Zhang Guo-Chang Fan Jin Zhang Zhao-liang Su Tian-qing Peng 
supported by the Canadian Institute of Health Research(Grant No.PJT-180304 to TQP);Projects of International Cooperation from Jiangsu,China(Grant No.BZ2024031 to ZLS).
Myocardial dysfunction is a decisive factor of death in septic patients.Cyclophilin F(PPIF)is a major component of the mitochondrial permeability transition pore(mPTP)and acts as a critical mPTP sensitizer triggering ...
关键词：SEPSIS cyclophilin F LPS myocardial dysfunction nicotinamide mononucleotide Mito-TEMPO 
A comprehensive step-by-step approach for the implementation of target trial emulation:Evaluating fluid resuscitation strategies in post-laparoscopic septic shock as an example
《Laparoscopic, Endoscopic and Robotic Surgery》2025年第1期28-44,共17页Jie Yang Lihui Wang Lin Chen Pengmin Zhou Suibi Yang Hongjie Shen Lifeng Xing Pengpeng Chen Yuetian Yu Hongying Ni Zhongheng Zhang 
Zhongheng Zhang received funding from the National Natural Science Foundation of China(82272180,82472243);the China National Key Research and Development Program(2023YFC3603104);the Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China(LHDMD24H150001);the China National Key Research and Development Program(2022YFC2504500);a collaborative scientific project co-established by the Science and Technology Department of the National Administration of Traditional Chinese Medicine and the Zhejiang Provincial Administration of Traditional Chinese Medicine(GZY-ZJKJ-24082);the General Health Science and Technology Program of Zhejiang Province(2024KY1099);Project of Zhejiang University Longquan Innovation Center(ZJDXLQCXZCJBGS2024016);Hongying Ni received funding from Jinhua Science and Technology Planning Project(2024-3-047).
Objective:To develop and demonstrate a comprehensive methodological framework for target trial emulation(TTE)implementation via post-laparoscopic septic shock fluid management as a clinical case study.Methods:We desig...
关键词：Laparoscopic surgery SEPSIS Target trial emulation 
Cathelicidin-HG Alleviates Sepsis-Induced Platelet Dysfunction by Inhibiting GPVI-Mediated Platelet Activation
《Research》2025年第1期371-384,共14页Weichen Xiong Jinwei Chai Jiena Wu Jiali Li Wancheng Lu Maolin Tian Mohamed Amine Jmel Johannes H.Ippel Michail Kotsyfakis Ingrid Dijkgraaf Shuwen Liu Xueqing Xu 
supported by the Key-Area Research and Development Program of Guangdong Province(2023B1111050008);the GuangDong Basic and Applied Basic Research Foundation(2023A1515010914)and the Key-Area Research and Development Program of Guangzhou(2024B03J0011);Our work received support also by the Czech Academy of Sciences within project No.NSFC-19-15(bilateral cooperation);“Belt and Road”Innovative Talent Exchange Foreign Expert Program(DL2023030011L).
Platelet activation contributes to sepsis development,leading to microthrombosis and increased inflammation,which results in disseminated intravascular coagulation and multiple organ dysfunction.Although Cathelicidin ...
关键词：nuclear magnetic resonance spectroscopythe platelet activation disseminated intravascular coagulation SEPSIS alleviate sepsisits 
Acupuncture therapy:A potential new strategy for immunosuppressive sepsis
《World Journal of Acupuncture-Moxibustion》2025年第1期17-26,共10页Shuang-li CHEN Li-hong HUANG Yu-hong BIAN Yu-ming WANG Jing-yu ZHANG Jin-yu LIAN Ya-man ZHENG Zi-yang FAN Xin-ru YUAN Xiao-yan LYU Pei-rong LUO Yu-xin FANG Li-yuan FU Ji-wen QIU Xiao-wei LIN Ze-lin CHEN Lian-qi GENG Yi GUO Ning-cen LI Bo CHEN 
Supported by the National Natural Science Foundation of China:No.82374563,82004467,82305370;China Postdoctoral Science Foundation:No.2022M721536;Tianjin Graduate Research Innovation Project:2022BKY177;TUTCM Graduate Research Innovation Project:YJSKC-20221016。
Sepsis is characterized by immune dysregulation that are responsible for an increase in secondary in-fections and mortality.Acupuncture is a potential alternative treatment for sepsis.In this comprehensive literature ...
关键词：SEPSIS IMMUNOSUPPRESSIVE ACUPUNCTURE Innate immune Adaptive immune 
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