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Cross-talk between lactate metabolism and immunity reveals CEP55 as a potential regulator in the immunosuppressive microenvironment of hepatocellular carcinoma: 《Genes & Diseases》2025年第3期42-45,共4页Jie Li Yuyuan Zhang Jinhai Deng Siyuan Weng Hui Xu Yuhao Ba Anning Zuo Shutong Liu Quan Cheng Jian Zhang Peng Luo Zhen Li Xinwei Han Zaoqu Liu; supported by the Major Science and Technology projects of Henan Province,China(No.221100310100).; The interaction of lactate metabolism with immunity plays a crucial role in the remodeling of the immune microenvironment and even in the heterogeneous progression of hepatocellular carcinoma(HCC).The intratumor-accum...; 关键词：cep hepatocellular carcinoma hepatocellular carcinoma hcc lactate metabolism IMMUNITY proliferation infiltration immunosuppressive cells remodeling immune microenvironment immunosuppressive microenvironment

Optimizing risk management for post-amputation wound complications in diabetic patients: Focus on glycemic and immunosuppressive control: 《World Journal of Diabetes》2025年第3期277-283,共7页Zhi-Peng Li Jin-Ke Sun Wei-Ping Fu Chang-Jiang Zhang; Supported by Henan Province Key Research and Development Program,No.231111311000;Henan Provincial Science and Technology Research Project,No.232102310411;Henan Province Medical Science and Technology Key Project,No.LHGJ20220566 and No.LHGJ20240365;Henan Province Medical Education Research Project,No.WJLX2023079;Zhengzhou Medical and Health Technology Innovation Guidance Program,No.2024YLZDJH022.; This study highlights the importance of identifying and addressing risk factors associated with wound complications following transtibial amputation in diabetic patients.These amputations,often necessitated by severe ...; 关键词：Transtibial amputation Diabetic foot Wound complications Risk factors Glycemic control Hemoglobin A1c Immunosuppressive therapy Kidney transplantation Personalized care Postoperative outcomes

Acupuncture therapy:A potential new strategy for immunosuppressive sepsis: 《World Journal of Acupuncture-Moxibustion》2025年第1期17-26,共10页Shuang-li CHEN Li-hong HUANG Yu-hong BIAN Yu-ming WANG Jing-yu ZHANG Jin-yu LIAN Ya-man ZHENG Zi-yang FAN Xin-ru YUAN Xiao-yan LYU Pei-rong LUO Yu-xin FANG Li-yuan FU Ji-wen QIU Xiao-wei LIN Ze-lin CHEN Lian-qi GENG Yi GUO Ning-cen LI Bo CHEN; Supported by the National Natural Science Foundation of China:No.82374563,82004467,82305370;China Postdoctoral Science Foundation:No.2022M721536;Tianjin Graduate Research Innovation Project:2022BKY177;TUTCM Graduate Research Innovation Project:YJSKC-20221016。; Sepsis is characterized by immune dysregulation that are responsible for an increase in secondary in-fections and mortality.Acupuncture is a potential alternative treatment for sepsis.In this comprehensive literature ...; 关键词：SEPSIS IMMUNOSUPPRESSIVE ACUPUNCTURE Innate immune Adaptive immune

Nanomaterials evoke pyroptosis boosting cancer immunotherapy: 《Acta Pharmaceutica Sinica B》2025年第2期852-875,共24页Zhenhua Li Ziyue Xi Chuanyong Fan Xinran Xi Yao Zhou Ming Zhao Lu Xu; supported by Scientific Research Project of Education Department of Liaoning Province(LJKMZ20221363,LJ212410163025,China).; Cancer immunotherapy is currently a very promising therapeutic strategy for treating tumors.However,its effectiveness is restricted by insufficient antigenicity and an immunosuppressive tumor microenvironment(ITME).Py...; 关键词：PYROPTOSIS NANOMATERIALS Gasdermin family Mechanism INDUCTION Cancer immunotherapy Programmed cell death Immunosuppressive tumor microenvironment

Basiliximab is superior to low dose rabbit anti-thymocyte globulin in pediatric kidney transplant recipients:The younger,the better: 《Chinese Medical Journal》2025年第2期225-227,共3页Lan Zhu Lei Zhang Wenjun Shang Wenhua Liu Rula Sa Zhiliang Guo Longshan Liu Jinghong Tan Hengxi Zhang Yonghua Feng Wenyu Zhao Wenqi Cong Jianyong Wu Changxi Wang Gang Chen; supported by the Clinical Research Flagship Project of Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology(No.2019CR108).; To the Editor:To reduce the risk of acute rejection(AR)after renal transplantation,immunosuppressive induction therapy has been commonly used in the perioperative period.At present,rabbit anti-thymocyte globulin(rATG)...; 关键词：acute rejection ar immunosuppressive induction therapy pediatric kidney transplantation rabbit anti thymocyte globulin kidney transplantationthe BASILIXIMAB induction agents

SLC40A1^(+)macrophages contribute to the immunosuppressive tumor microenvironment in EGFR-mutated lung cancer: 《Science Bulletin》2025年第1期47-50,共4页Xinyu Song Zongjuan Li Xuanhe Wang He Du Yijun Jia Shen Chen Anwen Xiong Wei Li Xuefei Li Lei Cheng Chao Zhao Lei Wang Guanghui Gao Xiaoxia Chen Chunyan Wu Zhikai Zhao Shengxiang Ren Caicun Zhou Fengying Wu; supported by the China Postdoctoral Science Foundation(2023M742119);the National Natural Science Foundation of China(82403395,82373319,and 82102766);the Natural Science Foundation of Shandong Province(ZR2024QH219);the National Key Clinical Program on Oncology;the Shanghai Science and Technology Innovation Action Plan Medical Innovation Research Special Project(23Y11908600)。; Patients with non-small cell lung cancer(NSCLC)harboring epidermal growth factor receptor(EGFR)mutations show a notable response to tyrosine kinase inhibitor(TKI)treatment.However,almost all patients eventually develo...; 关键词：LUNG cancer eventually

A GSH-Responsive Immune-Stimulating Polypeptide Hydrogel Loaded with Chemotherapeutics,IDO Inhibitor and Immune Checkpoint Blocking Antibody for Enhanced Anti-Tumor Chemo-Immunotherapy: 《Chinese Journal of Chemistry》2024年第23期2957-2969,共13页Junfeng Ding Tianran Wang Yan Rong Chaoliang He Xuesi Chen; financially supported by the National Natural Science Foundation of China(Projects 52173147,52203202,51973218);the Scientific and Technological Development Projects of Jilin Province(20240202002GX).; Due to the immunosuppressive tumor microenvironment(TME),T cells are usually inactivated and tend to differentiate into regulatory T cells(Tregs)in the tumor tissues,which seriously hinders the anti-tumor efficiency o...; 关键词：Immune-stimulating hydrogel POLYPEPTIDE Stimuli-responsive Immunotherapy Immunosuppressive microenvironment Cancertreatment Drug delivery

Targeting the LMP1-ALIX axis in EBV^(+)nasopharyngeal carcinoma inhibits immunosuppressive small extracellular vesicle secretion and boosts anti-tumor immunity: 《Cancer Communications》2024年第12期1391-1413,共23页Fajian He Yan Gong Gan Tao Jianguo Zhang Qiuji Wu Yushuang Tan Yajie Cheng Chunsheng Wang Jinru Yang Linzhi Han Zhihao Wang Yanping Gao Jingyi He Rui Bai Peikai Sun Xiaoyan Yu Yajuan Zhou Conghua Xie; Health Commission of Hubei Province Medical Leading Talent Project,and Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University,Grant/Award Numbers:ZNJC201922,ZNJC202007;Key Research&Development Project of Hubei Province,Grant/Award Number:2020BCA069;National Natural Science Foundation of China,Grant/Award Numbers:81803065,81972852;Research Projects of Biomedical Center of Hubei Cancer Hospital,Grant/Award Number:2022SWZX12。; Background:Immunotherapy has revolutionized the therapeutical regimen for nasopharyngeal carcinoma(NPC),yet its response rate remains insufficient.Programmed death-ligand 1(PD-L1)on small extracellular vesicles(sEVs)m...; 关键词：Epstein-Barr virus latent membrane protein 1 small extracellular vesicle PD-L1 ALIX nasopharyngeal carcinoma

Multi-synergistic chemotherapeutic drug assemblies to activate colorectal cancer immunotherapy by modulating the multilevel immunosuppressive characteristics: 《Aggregate》2024年第6期187-201,共15页Rongrong Zheng Chuyu Huang Hangyu Zhou Lixin Zhao Qiuyuan Li Guangmiao Chen Linping Zhao Shiying Li; Basic and Applied Basic Research Foundation of Guangdong Province,Grant/Award Numbers:2021B1515020043,2023A1515012628;National Natural Science Foundation of China,Grant/Award Numbers:32371394,82302355;Science and Technology Program of Guangzhou,Grant/Award Numbers:2024A04J3324,2024A03J0078;National Key Research and Development Program of China,Grant/Award Numbers:2021YFD1800600,2022YFE0209700。; The life-threatening colorectal cancer exhibits multilevel immunosuppressive characteristics,including low immunogenicity,abnormal cellular metabolism,and acidic immunosuppressive microenvironment.In this work,multi-s...; 关键词：colorectal cancer drug assemblies IMMUNOTHERAPY photodynamic therapy tumor metabolism

Differentiation and immunosuppressive function of CD19^(+)CD24^(hi)CD27^(+) regulatory B cells are regulated through the miR-29a-3p/NFAT5 pathway: 《Hepatobiliary & Pancreatic Diseases International》2024年第5期472-480,共9页Jin-Yang Li Tian-Shuo Feng Ji Gao Xin-Xiang Yang Xiang-Cheng Li Zhen-Hua Deng Yong-Xiang Xia Zheng-Shan Wu; supported by grants from the National Natural Science Foundation of China (82070676);Jiangsu Provincial Medi-cal Innovation Center (CXZX202203);Jiangsu Provincial Medi-cal Key Laboratory (ZDXYS202201)。; Background: Regulatory B cells(Bregs) is an indispensable element in inducing immune tolerance after liver transplantation. As one of the microRNAs(miRNAs), mi R-29a-3p also inhibits translation by degrading the targe...; 关键词：Regulatory B cells miR-29a-3p NFAT5 Liver transplantation

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