POLYPEPTIDE

作品数：239被引量：460H指数：9
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Effect of beinaglutide,a thrice-daily GLP-1 receptor agonist,on body weight and metabolic parameters:A systematic review and metaanalysis
《World Journal of Diabetes》2025年第5期374-387,共14页Abul Bashar Mohammad Kamrul-Hasan Vanishri Ganakumar Lakshmi Nagendra Deep Dutta M Rafiqul Islam Joseph M Pappachan 
BACKGROUND Beinaglutide,a short-acting glucagon-like polypeptide-1 receptor agonist,has shown variable efficacy in weight reduction and metabolic control in randomized controlled trials(RCTs).AIM To summarize the ther...
关键词：Beinaglutide Glucagon-like polypeptide-1 receptor agonist OBESITY Type 2 diabetes Weight reduction Metaanalysis 
Is global interest in fasting,intermittent fasting and the liver shifting?
《World Journal of Hepatology》2025年第4期151-154,共4页Athanasios Tselebis Lina Zabuliene Ioannis Ilias 
A recent article highlighted the hepatic benefits of intermittent fasting,particularly during Ramadan.However,the rising use of glucagon-like peptide-1(GLP-1)/glucose-dependent insulinotropic polypeptide(GIP)receptor ...
关键词：Intermittent fasting Glucagon-like peptide-1 receptor agonists Glucosedependent insulinotropic polypeptide receptor agonists Weight management Diet trends HEPATIC Public health behavior 
Antidiabetic combination therapy and cardiovascular outcomes:An evidence-based approach
《World Journal of Diabetes》2025年第4期8-18,共11页Vanishri Ganakumar Cornelius J Fernandez Joseph M Pappachan 
Type 2 diabetes mellitus is associated with a 2-4 times increased risk of cardiovascular(CV)disease.Glucagon-like polypeptide-1 receptor agonists(GLP1RA)and sodium-glucose cotransporter-2 inhibitors(SGLT2i)are two imp...
关键词：Glucagon-like polypeptide-1 receptor agonists Sodium-glucose cotransporter-2 inhibitors Cardiovascular disease Type 2 diabetes mellitus Cardiovascular outcome trials 
Systemically intravenous siRNA delivery into brain with a targeting and efficient polypeptide carrier and its evaluation on anti-glioma efficacy
《Chinese Chemical Letters》2025年第3期396-401,共6页Liqing Chen Zheming Zhang Yanhong Liu Chenfei Liu Congcong Xiao Liming Gong Mingji Jin Zhonggao Gao Wei Huang 
supported by CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-026,China).
Gliomas are the most common intracranial tumors with poor survival and high mortality.Furthermore,the clinical efficacy of current drugs is still not ideal;despite the development of several therapeutic drugs over the...
关键词：15-Amino-acid peptide GLIOMA Brain targeting Gene silencing Transvascular delivery 
A GSH-Responsive Immune-Stimulating Polypeptide Hydrogel Loaded with Chemotherapeutics,IDO Inhibitor and Immune Checkpoint Blocking Antibody for Enhanced Anti-Tumor Chemo-Immunotherapy
《Chinese Journal of Chemistry》2024年第23期2957-2969,共13页Junfeng Ding Tianran Wang Yan Rong Chaoliang He Xuesi Chen 
financially supported by the National Natural Science Foundation of China(Projects 52173147,52203202,51973218);the Scientific and Technological Development Projects of Jilin Province(20240202002GX).
Due to the immunosuppressive tumor microenvironment(TME),T cells are usually inactivated and tend to differentiate into regulatory T cells(Tregs)in the tumor tissues,which seriously hinders the anti-tumor efficiency o...
关键词：Immune-stimulating hydrogel POLYPEPTIDE Stimuli-responsive Immunotherapy Immunosuppressive microenvironment Cancertreatment Drug delivery 
Effect of fermented polypeptide of Sacha Inchi(Plukenetia volubilis L.)on the structure of liquid crystal emulsion
《日用化学工业（中英文）》2024年第12期1456-1464,共9页Xiaochun Liu Tingting Luo Jie Dai Laicheng Chen Qiuxing He 
广东省教育厅2020年度普通高校重点科研平台和项目(2020ZDZX2101)。
In order to study the action mechanism of Sacha Inchi polypeptide in liquid crystal emulsion,oil-in-water liquid crystal emulsions with Sacha Inchi fermented polypeptide as the active component were prepared.The micro...
关键词：Sacha Inchi polypeptide liquid crystal emulsion liquid crystal structure RHEOLOGY 
Stimuli-evoked NOergic molecules and neuropeptides at acupuncture points and the gracile nucleus contribute to signal transduction of propagated sensation along the meridian through the dorsal medulla-thalamic pathways
《Journal of Integrative Medicine》2024年第5期515-522,共8页Sheng-xing Ma 
possible by National Institutes of Health Grant(No.AT002478,AT004620,and AT004504)from the National Center for Complementary and Integrative Medicine.
Numerous studies from different international groups have demonstrated that sensations can be propagated along acupuncture channel pathways.The propagated sensation along the channel pathway(PSCP)can be elicited by el...
关键词：Axon reflex Nitric oxide Biophysical approaches Calcitonin related polypeptide Dorsal funiculus tract Meridian system 
Reduced Macrophage Uptake of Nanoparticles through Surface Modification of Polypeptides with Valine Residues被引量：1
《Chinese Journal of Chemistry》2024年第11期1209-1216,共8页Ning Li Shanshan Xiao Xiaoxiong Jin Ziyuan Song 
supported by the National Natural Science Foundation of China(22101194);Natural Science Foundation of Jiangsu Province(BK20210733);Suzhou Municipal Science and Technology Bureau(ZXL2021447)。
The structural and surface properties of nanomedicines play an important role in determining their biological fate. Surface chemistry of nanomedicines is one of the key parameters, where researchers used various strat...
关键词：NANOPARTICLES Copolymers Structure-activity relationships Surface chemistry POLYPEPTIDE Macrophage uptake 
Targeted screening of an anti-inflammatory polypeptide from Rhopilema esculentum Kishinouye cnidoblasts and elucidation of its mechanism in alleviating ulcerative colitis based on an analysis of the gut microbiota and metabolites
《Food Science and Human Wellness》2024年第3期1336-1347,共12页Ziyan Wang Qiuyue Shi Ying Feng Jiaojiao Han Chenyang Lu Jun Zhou Zhonghua Wang Xiurong Su 
sponsored by the National Key R&D Program of China (2018YFD0901102);the Natural Science Foundation of Zhejiang Province (LQ22D060002);the Fund of State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products (ZS20190105);the Fundamental Research Funds for the Provincial Universities of Zhejiang (SJLY2021015);the K.C.Wong Magna Fund of Ningbo University。
Ulcerative colitis(UC)is a recurrent inflammatory bowel disease that imposes a severe burden on families and society.In recent years,exploiting the potential of marine bioactive peptides for the treatment of diseases ...
关键词：Ulcerative colitis Rhopilema esculentum Kishinouye Cnidoblasts Marine bioactive polypeptides METAGENOME Serum metabolome 
Accelerated heterogenous ring-opening polymerization towards well-defined helical poly(N-allyl alanine)with clickable side chains
《Science China Chemistry》2024年第6期2056-2062,共7页Anyao Ma Xin Wang Sunting Xuan Zhengbiao Zhang 
supported by the National Natural Science Foundation of China(22201197,21925107);the Collaborative Innovation Center of Suzhou Nano Science and Technology,National Key R&D Program of China(2022YFB3704900);the Natural Science Foundation of Jiangsu Province(BK20220507);the Natural Science Foundation of Jiangsu Higher Education Institutions(21KJB150035)。
Well-defined poly(N-allyl alanine)has been synthesized by heterogenous ring-opening polymerization(HROP)of less reactive N-allyl-alanine N-carboxyanhydride,using acetic acid as the catalyst and benzylamine as the init...
关键词：heterogenous ring-opening polymerization controlled polymerization stable helix clickable N-substituted polypeptide di-substituted polypeptoid 
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