Reduced Macrophage Uptake of Nanoparticles through Surface Modification of Polypeptides with Valine Residues  

作　　者：Ning Li Shanshan Xiao Xiaoxiong Jin Ziyuan Song 

机构地区：[1]Institute of Functional Nano&Soft Materials(FUNSOM),Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices,Soochow University,Suzhou,Jiangsu,215123 China

出　　处：《Chinese Journal of Chemistry》2024年第11期1209-1216,共8页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(22101194);Natural Science Foundation of Jiangsu Province(BK20210733);Suzhou Municipal Science and Technology Bureau(ZXL2021447)。

摘　　要：The structural and surface properties of nanomedicines play an important role in determining their biological fate. Surface chemistry of nanomedicines is one of the key parameters, where researchers used various strategies such as PEGylation to avoid the undesired clearance of nanoparticles (NPs) for enhanced targeting effect. Nevertheless, the fine-tuning of surface chemistry through polymer functionalization remains largely unexplored. In this concise report, we find that the incorporation of only 10 mol% valine residues into the surface-anchored poly(L-glutamic acid) significantly lowered the macrophage uptake of NPs. The introduction of other hydrophobic amino acid residues, however, increased the NPs internalization instead. The chirality and the side-chain structure of valine played an important role in the unexpected uptake behavior. We believe this work highlights the impact of slight changes of the surface-anchored polymer structure on the behavior of NPs, drawing people's attention to the careful design of surface chemistry to optimize the nanomedicine design.

关 键 词：NANOPARTICLES Copolymers Structure-activity relationships Surface chemistry POLYPEPTIDE Macrophage uptake 

分 类 号：O62[理学—有机化学]