Acupuncture therapy:A potential new strategy for immunosuppressive sepsis  

针刺疗法:一种潜在治疗免疫抑制性脓毒症的新策略

作　　者：Shuang-li CHEN Li-hong HUANG Yu-hong BIAN Yu-ming WANG Jing-yu ZHANG Jin-yu LIAN Ya-man ZHENG Zi-yang FAN Xin-ru YUAN Xiao-yan LYU Pei-rong LUO Yu-xin FANG Li-yuan FU Ji-wen QIU Xiao-wei LIN Ze-lin CHEN Lian-qi GENG Yi GUO Ning-cen LI Bo CHEN 陈双莉;黄礼红;边育红;王玉明;张靖宇;廉金玉;郑雅蔓;樊紫阳;袁馨如;吕笑颜;罗佩蓉;房钰鑫;傅丽媛;邱继文;林小伟;陈泽林;耿连歧;郭义;李柠岑;陈波(天津中医药大学针灸推拿学院,天津301617;天津中医药大学针灸研究中心,天津301617;天津中医药大学中西医结合学院,天津301617;天津中医药大学中药学院,天津301617;天津中医药大学天津市现代中医理论创新转化重点实验室,天津301617;天津中医药大学医学技术学院,天津301617;天津市滨海新区中医医院暨天津中医药大学第四附属医院,天津300451;南方医科大学南方医院,广州516006)

机构地区：[1]School of Acu-moxibustion and Tuina,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China [2]Acupuncture Research Center,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China [3]School of Integrative Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China [4]School of Traditional Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China [5]Tianjin Key Laboratory of Modern Chinese Medicine Theory Innovation and Application,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China [6]School of Medical Technology,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China [7]Tianjin Binhai New Area Hospital of Traditional Chinese Medicine,Fourth Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300451,China [8]Nanfang Hospital,Southern Medical University,Guangzhou 516006,China

出　　处：《World Journal of Acupuncture-Moxibustion》2025年第1期17-26,共10页世界针灸杂志(英文版)

基　　金：Supported by the National Natural Science Foundation of China:No.82374563,82004467,82305370;China Postdoctoral Science Foundation:No.2022M721536;Tianjin Graduate Research Innovation Project:2022BKY177;TUTCM Graduate Research Innovation Project:YJSKC-20221016。

摘　　要：Sepsis is characterized by immune dysregulation that are responsible for an increase in secondary in-fections and mortality.Acupuncture is a potential alternative treatment for sepsis.In this comprehensive literature review,we found that acupuncture is beneficial in treating immune disorders associated with sepsis.Acupuncture can improve immune disorders associated with sepsis and regulate the functions of innate and adaptive immune cells.Specifically,acupuncture can reduce the number of neutrophils in sep-sis,promote the polarization of macrophages towards M2-like macrophages,and alleviate inflammation by reducing the activation of microglia and astrocytes.Furthermore,acupuncture can increase the per-centage of T cells and modulate the balance between T cell subsets.The immunomodulatory mechanism of acupuncture in sepsis may be attributed to the balance of the autonomic nervous system,including activation of the sympathetic-adrenal axis,vagal-cholinergic pathway,and vagal-adrenal axis.In addition,acupuncture can inhibit inflammation by preserving the integrity of the intestinal barrier and regulating the composition of the intestinal microbiota.Clinical studies have also demonstrated that acupuncture can enhance the number of peripheral natural killer(NK)cells and T cell subsets,as well as the expres-sion of human leukocyte antigen DR(HLA-DR).Moreover,acupuncture can decrease the ratio of white blood cells to neutrophils and reduce the levels of inflammatory factors.Therefore,acupuncture has the potential to improve immune function in sepsis.Further investigation of its mechanism is expected to provide a scientific and reliable foundation for the application of acupuncture in sepsis treatment.

关 键 词：SEPSIS IMMUNOSUPPRESSIVE ACUPUNCTURE Innate immune Adaptive immune 

分 类 号：R24[医药卫生—中医临床基础]