Study of the relationship between iron metabolism disorders and sepsis-associated liver injury:A prospective observational study  

作　　者：Tian-Wei Wang Lu-Lu Zhou Jing Yuan Wen-Xin Zhou Hao-Ran Wang Ting-Ting Yu Ji-Chao Zhai Cheng-Bin Tang Wei Jiang Jiang-Quan Yu Rui-Qiang Zheng Hai-Long Yu Jun Shao 

机构地区：[1]Department of Intensive Care Unit,Northern Jiangsu People’s Hospital Affiliated to Yangzhou University,Yangzhou 225001,Jiangsu Province,China [2]Department of Functional Examination,Northern Jiangsu People’s Hospital Affiliated to Yangzhou University,Yangzhou 225001,Jiangsu Province,China [3]Department of Oncology,First Affiliated Hospital of Nanjing Medical University,Nanjing 210000,Jiangsu Province,China [4]Department of Center for Cardiac Macrovascular Disease,Northern Jiangsu People’s Hospital Affiliated to Yangzhou University,Yangzhou 225001,Jiangsu Province,China [5]Department of Neuro Intensive Care Unit,Northern Jiangsu People’s Hospital Affiliated to Yangzhou University,Yangzhou 225001,Jiangsu Province,China [6]Department of Neurology,Northern Jiangsu People’s Hospital Affiliated to Yangzhou University,Yangzhou 225001,Jiangsu Province,China

出　　处：《World Journal of Gastroenterology》2025年第14期71-82,共12页世界胃肠病学杂志(英文)

基　　金：Supported by the National Science Foundation of Jiangsu Province,No.BK20221280;the National Natural Science Foundation of China,No.82371336;the Chinese Postdoctoral Science Foundation,No.2022M711426;the Special Fund for Social Key Research and Development Plan of Yangzhou City,No.YZ2022097;Yangzhou Municipal Science and Technology Bureau,No.YZ2024091 and No.YZ2022098.

摘　　要：BACKGROUND Sepsis-associated liver injury(SALI)refers to secondary liver function impairment caused by sepsis,patients with SALI often have worse clinical outcomes.The early identification and assessment of the occurrence and progression of SALI are pressing issues that urgently need to be resolved.AIM To investigate the relationship between iron metabolism and SALI.METHODS In this prospective study,139 patients were recruited,with 53 assigned to the SALI group.The relationships between SALI and various iron metabolism-related biomarkers were examined.These biomarkers included serum iron(SI),total iron-binding capacity(TIBC),serum ferritin,transferrin,and transferrin saturation.To identify independent risk factors for SALI,both univariate and multivariate logistic regression analyses were performed.Additionally,receiver operating characteristic curve analysis was utilized to assess the predictive value of these biomarkers for the occurrence of SALI.RESULTS There were no statistically significant differences in age,sex,body mass index,Sequential Organ Failure Assessment scores(excluding liver function),or APACHE II scores between the two groups of patients.Compared with the sepsis group,the SALI group presented significantly higher SI(P<0.001),TIBC(P<0.001),serum ferritin(P=0.001),transferrin(P=0.005),and transferrin saturation levels(P<0.001).Multivariate logistic regression analysis revealed that SI(odds ratio=1.24,95%confidence interval:1.11-1.40,P<0.001)and TIBC levels(odds ratio=1.13,95%confidence interval:1.05-1.21,P<0.001)were independent predictors of SALI.Receiver operating characteristic curve analysis revealed that SI and TIBC had areas under the curve of 0.816 and 0.757,respectively,indicating moderate predictive accuracy for SALI.CONCLUSION Iron metabolism disorders are closely associated with the development of SALI,and SI and TIBC may serve as potential predictive biomarkers.The combined use of SI and TIBC has superior diagnostic efficacy for SALI.These findings provide valuable insights for the ear

关 键 词：SEPSIS Liver injury Iron metabolism Biomarkers Serum iron Total iron-binding capacity 

分 类 号：R459.7[医药卫生—急诊医学]