Rethinking neurodegenerative diseases:neurometabolic concept linking lipid oxidation to diseases in the central nervous system  

作　　者：Steinunn Sara Helgudóttir Anne Skøttrup Mørkholt Jacek Lichota Preben Bruun-Nyzell Mads Christian Andersen Nanna Marie Juhl Kristensen Amanda Krøger Johansen Mikela Reinholdt Zinn Hulda Maria Jensdóttir John Dirk Vestergaard Nieland 

机构地区：[1]2N Pharma ApS,NOVI Science Park,Aalborg,Denmark [2]Molecular Pharmacology Group,Department of Health Science and Technology,Aalborg University,Aalborg,Denmark

出　　处：《Neural Regeneration Research》2024年第7期1437-1445,共9页中国神经再生研究（英文版）

摘　　要：Currently,there is a lack of effective medicines capable of halting or reve rsing the progression of neurodegenerative disorde rs,including amyotrophic lateral sclerosis,Parkinson s disease,multiple sclerosis,or Alzheimer s disease.Given the unmet medical need,it is necessary to reevaluate the existing para digms of how to to rget these diseases.When considering neurodegenerative diseases from a systemic neurometabolic perspective,it becomes possible to explain the shared pathological features.This innovative approach presented in this paper draws upon exte nsive research conducted by the authors and researchers worldwide.In this review,we highlight the importance of metabolic mitochondrial dysfunction in the context of neurodegenerative diseases.We provide an overview of the risk factors associated with developing neurodegenerative disorders,including genetic,epigenetic,and environmental fa ctors.Additionally,we examine pathological mechanisms implicated in these diseases such as oxidative stress,accumulation of misfolded proteins,inflammation,demyelination,death of neurons,insulin resistance,dysbiosis,and neurotransmitter disturbances.Finally,we outline a proposal for the restoration of mitochondrial metabolism,a crucial aspect that may hold the key to facilitating curative therapeutic interventions for neurodegenerative disorders in forthcoming advancements.

关 键 词：brain disease carnitine palmitoyl transferase 1 EPIGENETICS metabolism gut microbiome mitochondrial dysfunction NEURODEGENERATION oxidative stress 

分 类 号：R741[医药卫生—神经病学与精神病学]