THYMINE

作品数：43被引量：18H指数：2
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相关领域：理学医药卫生更多>>
相关作者：周仁武张先徽杨思泽林小伟顾斌更多>>
相关机构：厦门大学中国科学技术大学南京信息工程大学里昂第一大学更多>>
相关期刊：《Science China(Life Sciences)》《Science China Chemistry》《Pharmacology & Pharmacy》《Computers, Materials & Continua》更多>>
相关基金：国家自然科学基金上海市自然科学基金福建省自然科学基金国家重点基础研究发展计划更多>>
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Computational investigations on target-site searching and recognition mechanisms by thymine DNA glycosylase during DNA repair process被引量：2
《Acta Biochimica et Biophysica Sinica》2022年第6期796-806,共11页Lingyan Wang Kaiyuan Song Jin Yu Lin-Tai Da 
the grants from the Natural Science Foundation of Shanghai(Nos.,20ZR1425400,21JC1403100);and the Startup Funding from Shanghai Center for Systems Biomedicine Shanghai Jiao Tong University(No.,WF220441503)。
DNA glycosylase, as one member of DNA repair machineries, plays an essential role in correcting mismatched/damaged DNA nucleotides by cleaving the N-glycosidic bond between the sugar and target nucleobase through the ...
关键词：DNA repair DNA glycosylase Markov state model molecular dynamics simulation 
Facile and diverse logic circuits based on dumbbell DNA-templated fluorescent copper nanoclusters and S1 nuclease detection
《Chinese Chemical Letters》2022年第5期2711-2714,共4页Zefeng Gu Anchen Fu Ru Qiu Ru Sun Zhijuan Cao 
the projects of Innovative research team of high-level local universities in Shanghai and a key laboratory program of the Education Commission of Shanghai Municipality (No. ZDSYS14005);Program for high-level local universities in Shanghai (No. IDF301027/022);Shanghai Agriculture Science and Technology Support Project (No. 21N31900500);the National Natural Science Foundation of China (No. 21505023)
DNA-based logic gates promote the development of molecular computing and show enormous potential in the fields of nanotechnology and biotechnology. Dumbbell oligonucleotides(DNA) with poly-thymine(poly-T) loops and a ...
关键词：Logic gates Dumbbell DNA templates Poly-thymine loops Copper nanoclusters Nucleic acid enzymes 
Increasing the Solubility of a Hydrophobic Molecule with Thymine-like Face by DNA via Supramolecular Interaction
《Chemical Research in Chinese Universities》2020年第2期281-284,共4页SHI Peijun ZHANG Zhe LIU Mingchun SUN Teng HE Xiaoyan MAO Chengde FANG Liang ZUO Hua 
Supported by the National Natural Science Foundation of China(No.21974111);the Chongqing Research Program of Basic Research and Frontier Technology,China(No.cstc2018jcyjAX0482);the Venture&Innovation Support Program for Chongqing Overseas Returnees,China(No.cx2018088);the Sichuan Applied Basic Research Project,China(No.2019YJ0603);the Sichuan Financial Innovation Capacity Improvement Project,China(No.2016GYSH-016).
Poor water-solubility of hydrophobic drugs greatly hampers drug design and creats delivery problems.The traditional way to improve the solubility is to add hydrotropes or excipients to supress aggregations.Here,a nove...
关键词：Polyadenine[poly(A)] Pyromellitic DIIMIDE Hydrogen bond force Increased SOLUBILITY 
Polymerase-tautomeric Model for Untargeted Delayed Base Substitution Mutations Formation during Error-prone and SOS Replication of Double-stranded DNA Containing Thymine and Adenine in Some Rare Tautomeric Forms
《Journal of Oncology Research》2019年第2期24-37,共14页Helen A.Grebneva 
Polymerase-tautomeric model for untargeted delayed base substitution mutations is proposed.Structural analysis of bases insertion showed that any canonical bases may be inserted opposite rare tautomeric forms of thymi...
关键词：Radiation-induced genomic instability Untargeted delayed base substitution MUTATIONS UV-mutagenesis Rare tautomeric forms of DNA bases Thymine adenine ERROR-PRONE REPLICATION SOS REPLICATION 
Theoretical Study of Interaction between Apalutamide Anticancer Drug and Thymine by DFT Method
《Chinese Journal of Structural Chemistry》2019年第10期1645-1663,1609,共20页SIYAMAK Shahab MASOOME Sheikhi MEHRNOOSH Khaleghian SHAMSA Sharifi SADEGH Kaviani 
supported by the National Academy of Sciences of Belarus
The main purpose of this study is a better comprehension of the non-bonded interaction between an anticancer drug apalutamide and deoxyribonucleic acid(DNA).In the prese nt work,the in teraction between an ticancer dr...
关键词：apalutamide THYMINE DFT ELF NBO 
The Stability of Anionic States of Thymine-Glycine Dimers with Excess Electron
《Computers, Materials & Continua》2018年第12期485-494,共10页Yugai Huang 
This work is supported by Natural Science Foundation of Jiangsu Province of China(No.BK20171456).
It has been demonstrated that low energy electrons(LEEs)can induce serious DNA damages including bases loss and even single and double strand breaks.Experiments also showed that LEE induced DNA damages will be reduced...
关键词：Low energy electrons(LEEs) DNA damage thymine-glycine dimers stability 
A rapid method for the detection of humic acid based on the poly(thymine)-templated copper nanoparticles
《Chinese Chemical Letters》2018年第1期136-138,共3页Changbei Ma Mingjian Chen Haisheng Liu Kefeng Wu Hailun He Kemin Wang 
supported by the National Natural Science Foundation of China(Nos. 21205142, 31370104);the Research Innovation Program for Graduates of Central South University (Nos. 2016zzts580, 2017zzts347)
This work described a new method for the detection of humic acid （HA） based on the poly（thymine） （polyT）-templated copper nanoparticles （CuNPs）. Without the presence of HA, the formation of poly T- templated C...
关键词：Label-freeHumic acidFluorescenceCopper nanoparticleCost-effective 
Simple, fast, label-free, and nanoquencher-free system for operating multivalued DNA logic gates using polythymine templated CuNPs as signal reporters
《Nano Research》2017年第8期2560-2569,共10页Daoqing Fan Erkang Wang Shaojun Dong 
This work was supported by the National Natural Science Foundation of China （Nos. 21375123, 21427811 and 21675151）.
Boolean logic devices play a key role in both traditional and nontraditional molecular logic circuits. This kind of binary logic, in which each bit is coded by （0, 1）, has only two output states--on or off （or high...
关键词：LABEL-FREE nanoquencher-free multivalued logic poly-thymine copper nanoparticles （CuNPs） 
Determination of Hg^2＋ in Tap Water Based on the Electro- chemiluminescence of Ru（phen）3^2＋ and Thymine at Bare and Graphene Oxide-Modified Glassy Carbon Electrodes被引量：1
《Chinese Journal of Chemistry》2016年第12期1297-1303,共7页Yulong Gao Tao Wang Fengyu Liu 
The electrochemiluminescence （ECL） of the Ru（phen）3^2＋/thymine （T） system at bare and graphene oxide （GO）-modified glassy carbon （GC） electrodes was utilized to determine Hg2＋ in tap water. The ECL intensi...
关键词：electrochemiluminescence （ECL） DETERMINATION 2＋ Hg THYMINE graphene oxide 
Multifaceted roles for thymine DNA glycosylase in embryonic development and human carcinogenesis被引量：3
《Acta Biochimica et Biophysica Sinica》2016年第1期82-89,共8页Xuehe Xu David S. Watt Chunming Liu 
Thymine DNA glycosylase （TDG） is a multifunctional protein that plays important roles in DNA repair, DNA demethylation, and transcriptional regulation. These diverse functions make TDG a unique enzyme in embryonic d...
关键词：TDG DNA repair DNA demethylation TRANSCRIPTION cancer 
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