Multifaceted roles for thymine DNA glycosylase in embryonic development and human carcinogenesis  

作　　者：Xuehe Xu David S. Watt Chunming Liu 

机构地区：[1]Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY40536-0509, USA

出　　处：《Acta Biochimica et Biophysica Sinica》2016年第1期82-89,共8页生物化学与生物物理学报（英文版）

摘　　要：Thymine DNA glycosylase （TDG） is a multifunctional protein that plays important roles in DNA repair, DNA demethylation, and transcriptional regulation. These diverse functions make TDG a unique enzyme in embryonic development and carcinogenesis. This review discusses the molecular function of TDG in human cancers and the previously unrecognized value of TDG as a potential target for drug therapy.Thymine DNA glycosylase （TDG） is a multifunctional protein that plays important roles in DNA repair, DNA demethylation, and transcriptional regulation. These diverse functions make TDG a unique enzyme in embryonic development and carcinogenesis. This review discusses the molecular function of TDG in human cancers and the previously unrecognized value of TDG as a potential target for drug therapy.

关 键 词：TDG DNA repair DNA demethylation TRANSCRIPTION cancer 

分 类 号：Q523[生物学—生物化学] Q55