TOLL-LIKE

作品数：156被引量：883H指数：15
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相关机构：首都医科大学中国医科大学广州中医药大学深圳市中医院更多>>
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Tumor derived cell-free nucleic acid upregulates programmed death-ligand 1 expression in neutrophil via intracellular Toll-like receptor signaling
《Cancer Communications》2025年第1期4-8,共5页Suguru Saito Duo-Yao Cao Tomohiro Shibata Yan Liu Aoi Otagiri-Hoshi Xiaojiang Cui Kenneth E.Bernstein 
supported by the National Institutes of Health grants(R01AI164519,2R01CA151610,R21CA280458);American Heart Association’s Career Development award(23CDA1052548);U.S.Department of Defense(W81XWH-18-1-0067)and the Glazer Foundation.
Neutrophils are innate immune cells that function predominantly against pathogens,while recent studies have revealed additional crucial roles in various diseases,including cancers[1–3].For instance,neutrophils expres...
关键词：DEATH diseases programmed 
Pien Tze Huang alleviates Concanavalin A-induced autoimmune hepatitis by regulating intestinal microbiota and memory regulatory T cells被引量：3
《World Journal of Gastroenterology》2023年第45期5988-6016,共29页Xin Zeng Miao-Hua Liu Yi Xiong Lin-Xin Zheng Kai-En Guo Hai-Mei Zhao Yu-Ting Yin Duan-Yong Liu Bu-Gao Zhou 
Supported by the National Natural Science Foundation of China,No.81603402,82060798,81860791;the Special Fund Project for Graduate Innovation of Jiangxi University of Chinese Medicine,No.JZYC22S77;a Special Fund Project for Graduate Innovation of Jiangxi Province,No.YC2022-s840,YC2022-B188;Jiangxi University of Chinese Medicine Science and Technology Innovation Team Development Program,No.CXTD22008;the Young and Middle-aged Backbone Talent Project of Jiangxi Administration of Traditional Chinese Medicine,No.[2020]05;Young Qhuang Scholars support Project of National Administration of Traditional Chinese Medicine,No.[2022]256.
BACKGROUND Traditional Chinese medicine has used the drug Pien Tze Huang(PTH),a classic prescription,to treat autoimmune hepatitis(AIH).However,the precise mode of action is still unknown.AIM To investigate the mechan...
关键词：Pien Tze Huang Autoimmune hepatitis Intestinal microbiota Memory regulatory T cell Toll-like receptor signaling 
Argon preconditioning protects neuronal cells with a Toll-like receptor-mediated effect被引量：4
《Neural Regeneration Research》2023年第6期1371-1377,共7页Stefanie Scheid Adrien Lejarre Jakob Wollborn Hartmut Buerkle Ulrich Goebel Felix Ulbrich 
supported by the Department of Anesthesiology and Critical Care,Medical Center-University of Freiburg,Germany;funded by the Baden-Wuerttemberg Ministry of Science,Research and Art and the University of Freiburg in the funding program Open Access Publishing
The noble gas argon has the potential to protect neuronal cells from cell death.So far,this effect has been studied in treatment after acute damage.Preconditioning using argon has not yet been investigated.In this stu...
关键词：apoptosis inflammation INTERLEUKIN-8 neuroprotection ROTENONE SH-SY5Y Toll-like receptor 2 Toll-like receptor 4 
Spatio-temporal delivery of both intra-and extracellular toll-like receptor agonists for enhancing antigen-specific immune responses被引量：1
《Acta Pharmaceutica Sinica B》2022年第12期4486-4500,共15页Nannan Wang Yueyue Zuo Shengjie Wu Chenlu Huang Linhua Zhang Dunwan Zhu 
This work was financially supported by National Natural Science Foundation of China(82072059 and 82172090);CAMS Innovation Fund for Medical Sciences(CIFMS,2021-I2M-1-058,China);Fundamental Research Funds for the Central Universities(2019PT320028 and 2019-0831-03,China);Tianjin Municipal Natural Science Foundation(20JCYBJC00030,China).
For cancer immunotherapy,triggering toll-like receptors(TLRs)in dendritic cells(DCs)can potentiate antigen-based immune responses.Nevertheless,to generate robust and long-lived immune responses,a well-designed nanovac...
关键词：Lipid-polymer hybrid nanoparticles TLR agonist combinations OVALBUMIN Monophosphoryl lipid AImiquimod NANOVACCINE Spatio-temporal manner Cancer immunotherapy 
黄芪甲苷通过Toll-like受体通路对HepG2高脂细胞脂质积累的抑制作用
《中国现代药物应用》2022年第22期184-189,共6页杨柳 熊小平 马国斌 李昱 胡林 丁海强 曾圣强 王洪 
江西省中医药科技计划项目(项目编号:2019A162);南昌医学院第一附属医院江西省人民医院博士启动基金(项目编号:19-236)。
目的探讨黄芪甲苷(AS-Ⅳ)对HepG2高脂细胞模型血脂代谢的影响以及Toll-like信号通路在其中的作用。方法使用HepG2细胞构建高脂血症模型,并随机分为六组:AS-Ⅳ低、中、高(0.05、0.1、0.2 mmol/L)剂量组,对照组,抑制剂组,AS-Ⅳ+抑制剂组...
关键词：黄芪甲苷 HepG2细胞 Toll-like通路 脂肪代谢 
Chaihu Longgu Muli Decoction relieving temporal lobe epilepsy in rats by inhibiting TLR4 signaling pathway through miR-146a-3p and miR-146a-5p被引量：1
《Digital Chinese Medicine》2022年第3期317-325,共9页MAO Yizhi LI Liang LUO Zhihong HUANG Yahui WU Huaying YANG Ping PENG Qinghua 
National Natural Science Foundation of China(81874429);Natural Science Foundation of Hunan Province(2020JJ5294);Traditional Chinese Medicine Science&Research Project of Hunan Province(202145);Excellent Youth Program of Hunan Education Department(21B0081);Hunan Provincial Administration of Traditional Chinese Medicine(D2022027);Changsha Natural Science Foundation of China(KQ2202255).
Objective To explore the effect and mechanism of Chaihu Longgu Muli Decoction(柴胡龙骨牡蛎汤,CHLGMLD)in rats with temporal lobe epilepsy(TLE).Methods A total of 80 Sprague-Dawley(SD)male rats were randomized into cont...
关键词：Chaihu Longgu Muli Decoction(柴胡龙骨牡蛎汤 CHLGMLD) Temporal lobe epilepsy MiR-146a-3p MiR-146a-5p Toll-like receptpr 4(TLR4)signaling pathway 
Targeting macrophagic SHP2 for ameliorating osteoarthritis via TLR signaling被引量：4
《Acta Pharmaceutica Sinica B》2022年第7期3073-3084,共12页Ziying Sun Qianqian Liu Zhongyang Lv Jiawei Li Xingquan Xu Heng Sun Maochun Wang Kuoyang Sun Tianshu Shi Zizheng Liu Guihua Tan Wenqiang Yan Rui Wu Yannick Xiaofan Yang Shiro Ikegawa Qing Jiang Yang Sun Dongquan Shi 
supported by the National Science Foundation of China(NSFC 81802196,81572129,81872877,91853109,and 81772335);Key Program of NSFC(81730067,China);Special Program of Chinese Academy of Science(XDA16020805,China);Jiangsu Provincial Key Medical Center Foundation(China);Jiangsu Provincial Medical Outstanding Talent Foundation(China);Jiangsu Provincial Key Medical Talent Foundation(China)。
Osteoarthritis(OA),in which M1 macrophage polarization in the synovium exacerbates disease progression,is a major cause of cartilage degeneration and functional disabilities.Therapeutic strategies of OA designed to in...
关键词：SHP2 SHP099 OSTEOARTHRITIS SYNOVITIS Toll-like receptor signaling MACROPHAGE Cartilage degradation M1 macrophage polarization 
Exogenous dendritic cells aggravate atherosclerosis via P-selectin/PSGL-1 pathway被引量：1
《BIOCELL》2020年第2期225-236,共12页LEI ZHONG LEI GUO ZHISHUAI YE SHANFENG ZHANG RONGCHONG HUANG 
the National Natural Science Foundation of China(Grant Nos.81770340,81100220).
Studies have found that a large number of inflammatory cells,P-selectin,and mature dendritic cells(DCs)are expressed in the damaged and shoulder parts of atherosclerotic plaque,which demonstrates that P-selectin and m...
关键词：GLYCOPROTEIN ligand TOLL-LIKE receptor 4 CORONARY heart disease 
Blockade of c-Src Within the Paraventricular Nucleus Attenuates Inflammatory Cytokines and Oxidative Stress in the Mechanism of the TLR4 Signal Pathway in Salt-Induced Hypertension被引量：6
《Neuroscience Bulletin》2020年第4期385-395,共11页Qing Yang Xiao-Jing Yu Qing Su Qiu-Yue Yi Xin-Ai Song Xiao-Lian Shi Hong-Bao Li Jie Qi Guo-Qing Zhu Yu-Ming Kang 
supported by the National Natural Science Foundation of China (81770426, 81600333, 81600330, and 81800373);China Postdoctoral Science Foundation (2016M602835);Shaanxi Postdoctoral Science Foundation (2016BSHEDZZ91).
Toll-like receptor 4 (TLR4) and cellular Src (cSrc) are closely associated with inflammatory cytokines and oxidative stress in hypertension, so we designed this study to explore the exact role of c-Src in the mechanis...
关键词：TOLL-LIKE receptor 4 Cellular Src Inflammatory cytokines Oxidative stress HYPOTHALAMIC PARAVENTRICULAR nucleus Salt-induced hypertension 
Innate Cytokine Responses and Toll-Like Receptor Induced by Recombinant Porcine Rotavirus VP6 and VP7 Proteins Expressing in <i>Lactobacillus plantarum</i>NC8 Strain Colonization in Mice
《World Journal of Vaccines》2020年第1期17-31,共15页Seria Masole Shonyela Wentao Yang Guilian Yang Chunfeng Wang 
The significant function of Toll-like receptors (TLR) is the detection of microbes by host guard cells that guide to the innate immune responses and to the successive adaptive. The current study patterns of TLR2, TLR3...
关键词：TOLL-LIKE Receptors RECOMBINANT Porcine ROTAVIRUS Lactobacillus plantaram MICE 
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